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Effect of Cyclocarya paliurus polysaccharides on streptozotocin-induced diabetic nephropathy in rats

Journal of Traditional Chinese Medicine 2020年第6期40卷 956-964页

作者： Xia Xichao Mao Dongxue Dai Hongmei Wu Xi Zhang Zuyuan Wang Huaying Zhou Wenwen Dong Yanmei Wang Mengqi Li Yuan Shao Xiangyang Ouyang Jingfeng Medical College Pingdingshan UniversityPingdingshan 467000China Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing 100700China

OBJEVTIVE:To investigate the efficacy of Cyclocarya paliurus(***)polysaccharides on streptozotocin-induced diabetic nephropathy in ***:Rats were divided into 6 groups,including group of normal control,group of diabetic control,group of metformin treatment,low-dose group of *** polysaccharides treatment,middle-dose group of *** polysaccharides treatment and high-dose group of *** polysaccharides *** analysis of kidney was analyzed using hematoxilin and *** of blood glucose,creatinine,urea,uric acid were determined by ***-oxidative enzymes were measured by real-time polymerase chain reaction(PCR)and enzyme-linked immunosorbent assay(ELISA).Advanced glycation end products(AGEs)and transforming growth factor-β1(TGF-β1)level was measured by ***:Abnormal changes were observed in the group of diabetic control characterized by atrophy of the renal glomeruli with hypercellularity,congestion of glomerular tufts,dilation of the renal spaces,and degeneration of renal *** with that of normal group,blood glucose,creatinine,urea,uric acid level was significantly increased in the group of diabetic *** dismutase,catalase,glutathione peroxidase,glutathione reductase level was significantly decreased,but AGEs and TGF-β1 level was significantly *** contrast,administration of *** polysaccharides and metformin could reverse the above-mentioned results of the group of diabetic control,especially in the high-dose group of *** ***:Our findings suggest that *** polysaccharides may play a protecting role for nephropathy of diabetic rats by lowering glucose,creatinine,urea,uric acid level,enhancing the antioxidative ability,and reducing AGEs and TGF-β1 expression.

关键词： Diabetic nephropathies Cyclocarya paliurus Polysaccharides antioxidatnts Glycation end products advanced Transforming growth factor beta1

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