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Antihyperglycemic and antioxidant activities of total alkaloids from Catharanthus roseus in streptozotocin-induced diabetic rats

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Journal of Forestry Research 2016年第1期27卷 167-174页

作者： Lin Zhang Gang Wei Yang Liu Yuangang Zu Qinghui Gai Lei Yang Key Laboratory of Forest Plant Ecology Ministry of Education Northeast Forestry University

We evaluated the hypoglycemic and antioxi- dant effects of the total alkaloids of leaves and twigs of Catharanthus roseus Linn. （CTA） in streptozotocin （STZ）- induced diabetic rats. The hypoglycemic effect was mea- sured by blood glucose and plasma insulin level. Oxidative stress was measured in heart, liver and kidney by levels of antioxidant markers, free radical scavengers and lipid peroxides i.e. superoxide dismutase （SOD）, catalase （CAT）, glutathione （GSH） and thiobarbituric acid reactive substances （TBARS）. Biochemical parameters, i.e. aspar- tate aminotransferase （AST）, alanine aminotransferase （ALT）, alkaline phosphate （ALP） were observed in diabetic control and treated rats. Oral administration of CTA for 30 days was followed by a significant （P 〈 0.05） decrease in fasting blood glucose and increase in insulin level as compared with untreated diabetic rats. Also it significantly （P 〈 0.05） reduced ALT, AST and ALP. The treatment also resulted in significant （P 〈 0.05） reductions in GSH, SOD, CAT, and decrease in TBARS in the heart, liver and kidney of diabetic rats. The results suggest that CTA can effectively normalize the impaired antioxidant status in STZ-induced diabetes in a dose-dependent *** exerted rapid protective effects against lipid peroxi- dation by scavenging of free radicals and reducing the risk of diabetic complications.

关键词： Antihyperglycemic activity antioxidantactivity Catharanthus roseus Streptozotocin-induceddiabetic rats Total alkaloids

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Optimization of Extraction of Antioxidants from Turmeric(Curcuma longa L.) Using Response Surface Methodology

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Wuhan University Journal of Natural Sciences 2018年第1期23卷 63-69页

作者： LIU Caiqin CHEN Weiqing WANG Nan JIN Jianchang College of Biology and Environment Engineering Zhejiang Shuren University

Turmeric is a spice widely used to enhance the taste and color of certain meats. We investigated the antioxidant capacities of turmeric ethanol soaking extracts by utilizing the scavenging properties of hydroxyl radical and 1,1-diphenyl-2-picrylhydrazyl（DPPH） free radical. The results showed that the optimum extraction parameters were： extraction time 4 h, sample-solvent ratio 1：84.12, solvent 72.34% ethanol solution, and water bath temperature 81.3 ℃. The optimum ethanol soaking extraction parameters were： extraction time 4 h, sample-solvent ratio 1：90.74, solvent 80.46% ethanol solution, water bath temperature 88.2 ℃. With these parameters, the hydroxyl radical scavenging rate and the DPPH free radical clearance of crude extracts from turmeric can reach about 93.78% and 40.69%, respectively. These results indicate that ethanol soaking extraction may be a useful method for extracting antioxidants from turmeric.

关键词： turmeric ethanol soaking extraction antioxidantactivity hydroxyl radical scavenging capacity 1,1-diphenyl-2-picrylhydrazyl(DPPH)scavenging capacity

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