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Anticancer,antiobesity,and anti-inflammatory activity of Artemisia species invitro

Journal of Traditional Chinese Medicine 2013年第1期33卷 92-97页

作者： Eunjeong Choi Heesook Park Jehyuk Lee Gunhee Kim Plant Resources Research Institute Duksung Women's University

OBJECTIVE： To investigate the anticancer, antiin flammatory, and antiobesity activity of methanol extracts of eight distinct species： Artemisia Stolon ifera （AST）, Artemisia Selengensis （ASE）, Artemisia .la ponica, Artemisia Montana, Artemisia Capillaris （ACA）, Artemisia Sylvatica （ASY）, Artemisio Keiskeana （AKE）, and Artemisia Scoparia （ASC） in vitro. METHODS： Antiproliferative activity was investigat ed in human breast cancer estrogen receptora pos itive T47D and negative HS578T cell lines exposed to the extracts at various concentrations （5200 mgl mL）for24, 48, and 72 h. For evaluating the antiin flammatory activity of the extracts, inhibition of ni trite synthesis was investigated in lipopolysaccha ride （LPS）stimulated cultures of macrophages cells exposed to 10, 50, 100, and 200 mglmL for 24 h. The antiobesity activity of the extracts was deter mined as triglyceride content and by a lipolysis as say in differentiated 3T3LI cells exposed to the extracts for 72 h at the same concentrations de scribed above. RESULTS： All extracts showed similar antiprolifera tive activity in a dose and timedependent man ner in HS578T cells. Although extracts at lower con centrations and shorter times stimulated growth of T47D cells, the antiproliferative effects of the extracts on T47D cells at higher concentrations （〉100 mg/ mL） for 72 h were significantly greater than those of HS578T cells. In case of antiinflammatory activi ty, some extracts （AST, ASE, ACA, and AKE） signifi cantly reduced nitric oxide production at higher concentrations in the presence of LPS compared with that in control cells. antiobesity activity was showed with reducing lipid accumulation signifi cantly （〉50%） at concentrations above 100 mg/mL in most extracts （except AST and ACA）. Additional ly, AKE and ASC increased lipolysis by 11%24% compared with that in the control. CONCLUSION： Artemisia spp. demonstrates poten tial as bioactive food supplements.

关键词： Artemisia Anticancer Anti-inflammatory antiobesity In vitro

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Anti-obesity effect and UHPLC-QTOF-MS/MS based metabolite profiling of Solanum nigrum leaf extract

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Asian Pacific Journal of Tropical Biomedicine 2022年第4期12卷 164-174页

作者： Zain Ul Aabideen Muhammad Waseem Mumtaz Muhammad Tayyab Akhtar Muhammad Asam Raza Hamid Mukhtar Ahmad Irfan Syed Ali Raza Muhammad Nadeem Yee Soon Ling Department of Chemistry University of GujratGujratPakistan Institute of Industrial Biotechnology GC University LahoreLahorePakistan Department of Chemistry College of ScienceKing Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia Research Center for Advanced Materials Science King Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia Department of Chemistry GC University LahoreLahorePakistan Sabah Occupational Safety Health and Environment AssociationLot331st FloorBlock EIramanis CenterJalanLinatas88450Kota KinabaluSabahMalaysia

Objective:To evaluate the antioxidant potential and pancreatic lipase inhibitory action of optimized hydroethanolic extracts of Solanum ***:Optimized extraction for maximum recovery of metabolites was performed using a combination of freeze-drying and ultrasonication followed by determination of antioxidant and antiobesity *** ultra-high performance liquid chromatography equipped with mass spectrometry was used to analyze metabolite profiling of Solanum *** studies were performed using molecular docking and electrostatic potential analysis for individual *** hypolipidemic potential of the most potent extract was assessed in the obese mice fed on fat rich ***:The 80%hydroethanolic extract exhibited the highest extract yield,total phenolic contents,total flavonoid contents along with the strongest 2,2-diphenyl-1-picrylhydrazyl scavenging activity,total antioxidant power,and pancreatic lipase inhibitory *** 80%hydroethanolic extract not only regulated the lipid profile of obese mice but also restricted the weight gain in the liver,kidney,and *** 80%hydroethanolic extract also reduced alanine transaminase and aspartate transaminase concentrations in *** effects of plant extract at 300 mg/kg body weight were quite comparable with the standard drug ***:Solanum nigrum is proved as an excellent and potent source of secondary metabolites that might be responsible for obesity mitigation.

关键词： Solanum nigrum Ultrasonication Metabolite profiling Total phenolic contents Total flavonoid content Antioxidant DPPH Total antioxidant power Pancreatic lipase UHPLC-QTOF-MS/MS antiobesity Mice Hypolipidemic Molecular docking

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The Anti-obesity Effect of Allium cepa L. leaves on High Fat Diet Induced Obesity in Male Wistar Rats

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Clinical Complementary Medicine and Pharmacology 2022年第3期2卷 28-36页

作者： Babafemi J.Momoh Shekins O.Okere Gabriel O.Anyanwu Department of Biochemistry Faculty of Science and TechnologyBingham UniversityP.M.B.005Karu 961105Nigeria

Background:Over the years,there has been research on the anti-obesity effect of the Allium cepa bulb,but a dearth of research was carried out on the leaves,which is consumed as vegetable salad and soup,hence this study was ***:This study aims at investigating the effect of *** leaves on high fat diet(HFD)induced obesity in male Wistar ***:Twenty-eight male Wistar rats were divided into four groups with seven rats *** from Group 1(normal control which received normal pelleted diet),obesity was induced in 21 rats of Group 2 to 4 with *** 2,the obese control was administered with 100%HFD,while the diet for group 3 and 4 was supplemented with 10%and 20%*** powdered leaves,respectively,for 28 ***:In the rats treated with 10%and 20%***,body weight,fat mass,blood glucose,total cholesterol,triglycerides,aspartate amino transferase,alanine amino transferase,creatinine and urea levels were reduced significantly(P<0.05)in comparison with the obese control *** liver of the rats treated with 10%and 20%*** leaves revealed small and few amounts of fat deposits in comparison with the obese control group,which revealed numerous and large deposits of *** kidney of the rats treated with 10%and 20%*** leaves showed moderate and mild inflammation,respectively,in comparison with the obese control group which showed acute *** leaves of *** had antioxidant properties and the presence of volatile compounds with anti-obesity properties in *** were identified using gas chromatography-mass spectrometry(GC-MS).Conclusion:*** leaves had weight-loss effect in that it decreased body weight,fat mass,glucose and lipid levels including fat deposits in the liver.

关键词： antiobesity Allium cepa High fat diet Total phenolic content Antioxidant Gas chromatography-mass spectrometry

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