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A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing

Chinese Chemical Letters 2010年第8期21卷 1011-1014页

作者： Yang Dong Hong Zhuo Liu Lu Xu Gang Li Zi Ning Ma Fei Han Hui Min Yao Yah Hui Sun San Ming Li School of Pharmaceutics Shenyang Pharmaceutical University Shenyang 110016 China China Criminal Police University Shenyang 110035 China

A membrane composed of an alginate（ALG） layer and a chitosan（CHS） layer with sustained antimicrobial efficacy was *** HC1（CIP） was incorporated into the ALG *** feature of the composite membrane was analyzed by scanning electron microscopy（SEM）.Water uptake capacity,in vitro drug release,and in vitro antimicrobial activity were *** composite membrane exhibited perfect binding characteristic between the two *** water uptake capacity of all the membranes was above 800%.The CIP could release from the composite membranes for 48 *** membrane could control the bacterial growth *** results suggested that this CHS/ALG composite membrane incorporated with CIP had the potential for wound dressing application.

关键词： Chitosan Alginate Composite membrane Ciprofloxacin HCl Sustained release antimicrobial efficacy

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Cultivation of Anabena variabilis,Synechococcus elongatus,Spirulina platensis for the production of C-Phycocyanin,C-Phycoerythrin and Thalassiosira,Skeletonema,Chaetoceros for fucoxanthin

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Systems Microbiology and Biomanufacturing 2021年第3期1卷 356-361页

作者： Bharti Mishra Archana Tiwari Diatom Research Laboratory Amity Institute of BiotechnologyAmity UniversityNoidaUttar Pradesh201313India

The pigments are vital parts of photosynthetic machinery in algae and exhibit a myriad of applications as nutraceuticals,cosmetics,colorants,which find huge applications in many industires,including the paint industry and paper *** antimicrobial,antioxidative,anti-inflammatory,and anti-cancer potential of microalgal pigments contribute towards their varied industrial *** this study,pigments(Fucoxanthin,C-phycocyanin,and C-phycoerythrin),extracted from microalgae were investigated to check the antimicrobial efficacy using agar well diffusion and disc diffusion methods against pathogenic bacteria:Staphylococcus aureus and Escherichia *** fucoxanthin pigment isolated from diatom Thalassiosira *** the highest antibacterial activity against Staphylococcus aureus(17±1.53 mm)and in contrast fucoxanthin pigment isolated from Chaetoceroes *** the highest bactericidal activity against Escherichia coli(18±1).The pigment extract of Spirulina plantesis showed the highest antibacterial activity against ***(41±0.3)and *** also exhibited high antibacterial activity against ***(32±0.5)while Anabaena variabilis showed the highest antibacterial activity against Staphylococcus aureus(34±0.5).The potential of microalgal pigments is highly valuable and further extensive studies can elaborate the underlying mechanisms.

关键词： antimicrobial efficacy Fucoxanthin Microalgae Phycocyanin Phycoerythrin

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Direct and Residual Microbicidal efficacy of Various Antiseptics against Multi-Drug Resistant Bacteria

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Advances in Infectious Diseases 2023年第4期13卷 596-608页

作者： Jose Ramon Martinez-Mendez Rafael Herruzo Angela Ojeda La Paz University Hospital Paseo de la Castellana Madrid Spain Autonomous University of Madrid Calle del Arzobispo Morcillo Madrid Spain

Background: Infections in ICU’s patients are known to often originate from the colonization of wounds by the patient’s endogenous microbiota, and to eventually lead to secondary sepsis. Aim: to compare in vitro the direct and residual effects after different exposure times of 4% chlorhexidine, and of 0.1% and 0.04% polyhexanide (in gel and solution forms), on ATCC-microorganisms, and too, on bacterial strains obtained from ICU patients. Methods: We used wild multi-drug resistant strains recently obtained from the wounds of patients hospitalized at ICU and reference strains from the American Type Culture Collection (ATCC). Chlorhexidine 4% was studied as a reference solution. The direct and residual effects of the 0.1% and 0.04% polyhexanide, in gel and solution forms, were analyzed using cotton germ carriers. To evaluate the direct effect, we exposed the strains to the antiseptic. To assess the residual effect, the germ-carriers were impregnated with antiseptic and were allowed to dry before we contaminated them. We inoculated the germ carriers in a culture medium with an inhibitor of antiseptic effect to count the number of surviving microorganisms. Findings: 0.1% Polyhexanide solution proved a direct and residual efficacy after 24 hours equivalent to 4% chlorhexidine. Is very important to highlight that this great efficacy did not change according to whether they were ATCC or multidrug-resistant strains. Conclusions: 0.1% polyhexanide demonstrated a great direct and residual efficacy (like 4% chlorhexidine), against multi-drug resistant strains isolated from ICU’s patients. Moreover, due to its few cytotoxicity against keratinocytes and fibroblasts can be an optimal antiseptic for burns, wounds or ulcers.

关键词： antimicrobial efficacy Antiseptic Multi-Drug Resistant Bacteria Tissue Toxicity Wounds

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