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Inflammatory bowel disease serology in Asia and the West

World Journal of Gastroenterology 2013年第37期19卷 6207-6213页

作者： Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan Department of Gastroenterology St Vincent’s HospitalFitzroy 3065MelbourneAustralia Department of Medicine University of Melbourne Department of Medicine Imperial College Department of Gastroenterology Box Hill Hospital Department of Medicine and Therapeutics Chinese University of Hong Kong Inflammatory Bowel Disease Center Department of GastroenterologySourasky Medical Center

AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease ***:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient *** eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both *** CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD *** and titres of ALCA,ACCA and AMCA did not differ between CD in the two *** of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ***:Serologic CD responses differ between HK Asian and Australian Caucasian *** genetic,environmental or disease pathogenic factors may account for these differences.

关键词： Crohn’s disease Ulcerative colitis Serological antibodies Asia Ethnic Anti-Saccharomyces cervisiae antibodies Anti-chitobioside antibodies antilaminaribioside antibodies Anti-mannobioside antibodies Atypical perinuclear anti-neutrophil cytoplasmic antibodies

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