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Relationship between Fas/ FasL expression and apoptosis of colon adenocarcinoma cell lines

World Journal of Gastroenterology 2001年第1期7卷 88-92页

作者： Zhi Hai Peng Tong Hai Xing Guo Qiang Qiu Hua Mei Tang Shanghai No. 1 People’s Hospital, Shanghai 200080, China Shanghai No.1 Peoples Hospital 85 Wujin Road Shanghai 200080 China. pengpzhb@***

INTRODUCTIONFas/ FasL system has been identified as a keymediator of apoptosis in tumor cells[1-4]. Theoccurrence and development of neoplasm are closelyrelated to apoptosis[5-7] Most chemotherapeuticdrugs kill cancer... 详细信息

关键词： Adenocarcinoma Colonic Neoplasms Antibiotics, Antineoplastic antigens, cd95 Antimetabolites, Antineoplastic Antineoplastic Agents Apoptosis Cisplatin Epirubicin Flow Cytometry Fluorouracil Gene Expression Regulation, Neoplastic Humans Membrane Glycoproteins Mitomycins Research Support, Non-U.S. Gov't Tumor Cells, Cultured

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Serum concentration of sFas and sFasL in healthy HBsAg carriers,chronic viral hepatitis B and C patients

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World Journal of Gastroenterology 2004年第24期10卷 3650-3653页

作者： Tadeusz Wojciech Lapinski Oksana Kowalczuk Danuta Prokopowicz Lech Chyczewski Department of Infectious Diseases Medical University of BialystokPoland Institute of Molecular Biology Medical University of BialystokPoland

AIM:To estimate the amount of apoptosis among healthy HBsAg carriers,patients with chronic HBV infection treated wibh lamivudine and patients with chronic HCV infection treated with interferon alpha and *** of apoptosis was evaluated by serum sFas/sFasL concentration measurement. Moreover dependence between apoptosis and HBV-DNA or HCV-RNA levels was studied. METHODS:Eighty-six persons were included into study:34 healthy HBsAg carders,33 patients with chronic HBV infecl^on and 19 patients with chronic HCV *** levels of sFas/sFasL were measured by ELISA ***-DNA and HCV-RNA were measured by RT-PCR *** of sFas/sFasL were determined before and 2 and 12 wk after therapy in patients with chronic hepatitis B and C infection. HBV-DNA or HCV-RNA was detected before treatment and 6 mo after treatment. RESULTS:Twenty-four (71%) healthy HBsAg carders showed HBV-DNA over 10~5/mL,which was comparable to the patients with chronic hepatitis *** from HBV-DNA levels, the concentration of sFas among healthy HBsAg carders was comparable to healthy *** patients with chronic hepatitis B and C,the concentration of sFas was significantly higher in comparison to healthy HBsAg carriers and healthy *** chronic hepatitis B patients the concentration of sFas was decreased during lamivudine *** chronic hepatitis C patients the concentration of sFas was increased during IFN alpha and ribavirin treatment,sFasL was not detected in control *** sFasL occurred more frequently in chronic hepatitis C patients in comparison to chronic hepatitis B patients. CONCLUSION:There are no correlations between apoptosis and HBV-DNA *** ther is an association between apoptosis and activity of inflammation in patients with chronic HBV *** can be increased in patients with chronic hepatitis C by effective treatment which may be a result of apoptosis stimulation by IFN-α.

关键词： Adolescent Adult Aged antigens, cd95 Apoptosis Biological Markers Carrier State DNA, Viral Female Hepatitis B Surface antigens Hepatitis B, Chronic Hepatitis C, Chronic Humans Lamivudine Male Membrane Glycoproteins Middle Aged RNA, Viral Reverse Transcriptase Inhibitors Solubility

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Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyi-N-nitro-N-nitrosoguanidine:influences on cell apoptosis and expression of its regulatory genes

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World Journal of Gastroenterology 2001年第3期7卷 394-398页

作者： Ru Tao Cui Gan Cai Zhao Bao Yin Yong Cheng Qiu Hong Yang Tao Tian Liver Center Beijing Friendship Hospital Affiliated to CapitalUniversity of Medical Sciences Department of Gastroenterology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai ChinaDepartment of Pathophysiology.Shanghai Medical University.ShanghaiChina Pathological Department Shanghai Medical University

INTRODUCTIONGastric epithelial dysplasia (GED) hypothetically is a straight-forward concept: dysplastic epithelium replacing the normal gastric epithelium of the stomach [1].In the stomach ,like any other segment of the gut ,it is defined as an unequivocal non-invasive epithelial change[2,3].The observation of gastric dysplasia as a cancerous lesion was recognized over a century ago ,but it is only after the advent of gastroscopy that its clinical significance has been stressed[4-7].

关键词： Animals antigens, cd95 Antineoplastic Agents Apoptosis Caspase 1 Cyclin D1 Gastric Mucosa Gene Expression Immunohistochemistry Male Membrane Glycoproteins Methylnitronitrosoguanidine RNA, Messenger Rats Rats, Wistar Research Support, Non-U.S. Gov't Stomach Diseases Tretinoin

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