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Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas

World Journal of Gastroenterology 2001年第1期7卷 53-59页

作者： Yan Xin Xiao Ling Li Yan Ping Wang Su Min Zhang Hua Chuan Zheng Dong Ying Wu Yin Chang Zhang The Fourth Laboratory of Cancer Institute, China Medical University, Shenyang 110001, Liaoning Province, China The Fourth Laboratory of Cancer Institute China Medical University Shenyang 110001 Liaoning Province China.

AIM: To reveal the correlation between the functional differentiation phenotypes of gastric carcinoma cells and the invasion and metastasis by a new way of cell-function ***:Surgically resected specimens of 361 gastric carcinomas(GC) were investigated with enzyme-, mucin-, and tumor-related marker immunohistochemistry. According to the direction of cell-function differentiation, stomach carcinomas were divided into five functionally differentiated types. RESULTS: (1) Absorptive function differentiation type (AFDT): there were 82 (22.7%) patients including 76 (92.7%) aged 45 years. Sixty-nine (84.1%) cases belonged to the intestinal type. Thirty-eight (46.3%) expressed cd44v6 and 9 (13.6%) of 66 male patients developed liver *** 5-year survival rate of patients in this group (58.5%) was higher than those with the other types (P cd44v6. The postoperative 5-year survival rate was 28.6%. (3) Absorptive and mucin-producing function differentiation type (AMPFDT): there were 180 (49.9%) cases, including 31 (17.2%) aged younger than 45 years. The tumor was more common in women (62, 34.4%,) and expressed more frequently estrogen receptors (ER) (129, 81.7%) than other types (P<0.01). Ovary metastasis was found in 12 (19.4%) out of 62 female subjects. The patients with this type GC had the lowest 5-year survival rate (24.7%) among all types. (4) Specific function differentiation type (SFDT): 13 (3.6%) cases. Nine (69.2%) tumors of this type derived from APUD system, the other 4 (30.7%) were of different histological differentiation. Sixty per cent of the patients survived at least five years. (5) Non-function differentiation type (NFDT): 32 (8.9%) cases. Nineteen (59.4%) cases had lymph node metastases but no one with liver or ovary metastasis. The 5-year surv

关键词： antigens, cd44 Cell Differentiation Female Glycoproteins Humans Immunohistochemistry Liver Neoplasms Lymphatic Metastasis Male Middle Aged Neoplasm Invasiveness Ovarian Neoplasms Phenotype Prognosis Receptors, Estrogen Research Support, Non-U.S. Gov't Stomach Neoplasms Survival Rate Tumor Markers, Biological

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Expression of cd44V6 and PCNA in squamous cell carcinomas

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Chinese Medical Journal 2002年第10期115卷 1564-1568页

作者：牛膺筠周占宇王红云刘夫玲青岛大学医学院附属医院眼科山东266003 青岛市第八人民医院眼科山东266003

OBJECTIVE: To investigate the expression of cluster of differentiation 44 variant 6 (cd(44V6)) and proliferating cell nuclear antigen (PCNA) in ocular squamous cell carcinomas. METHODS: Streptavidin-biotin complex (SABC) immunohistochemistry was used to explore the expression of cd(44V6) and PCNA in 35 cases of ocular squamous cell carcinomas, 20 cases of papillomas, and 11 cases of normal eyelid tissue. RESULTS: The cd(44V6) positive rate was 62.9% (22/35) in ocular squamous cell carcinomas, 15.0% (3/20) in papillomas, but not detectable in the 11 cases of normal eyelid tissue. The positive expression rates of cd(44V6) in ocular squamous cell carcinomas were significantly higher than in benign tumors (chi(2) = 11.57, P

关键词： antigens, cd44 Carcinoma, Squamous Cell Eye Neoplasms Glycoproteins Humans Immunohistochemistry Lymphatic Metastasis Proliferating Cell Nuclear Antigen Skin

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Levels of v5 and v6 cd44 splice variants in serum of patients with colorectal cancer are not correlated with pT stage,histopathological grade of malignancy and clinical features

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World Journal of Gastroenterology 2004年第4期10卷 583-585页

作者： Bogdan Zalewski 2nd Department of General and Gastroenterological Surgery Medical University of BialystokPoland

AIM:This study was designed to compare the levels of v5 and v6 splice variants of cd44 evaluated using EITSA test in the serum of patients with colorectal cancer in different stages of progression of the disease estimated in pT stage according to WHO score,histopathological grade of malignancy and some clinicopathological features. METHODS:The serum obtained from 114 persons with colorectal adenocarcinomas was examined using ELISA method,pT stage and grade of malignancy of the tumour were examined in formalin fixed and paraffin embedded materials obtained during operation. RESULTS:Only the level of cd44 v5 in the serum of patients before operation with G2 pT4 tumour was lower than that in other probes and the difference was statistically significant. We did not find any other correlations between the level of v5 and v6 cd44 variants and other evaluated parameters. CONCLUSION:The level of cd44 v5 and v6 estimated by ELISA test in the serum can not be used as a prognostic factor in colorectal cancer.

关键词： Alternative Splicing Adenocarcinoma Adult Aged Aged, 80 and over antigens, cd44 Colorectal Neoplasms Disease Progression Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged Predictive Value of Tests Prognosis Tumor Markers, Biological

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