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Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson’s disease

Translational Neurodegeneration 2023年第1期12卷 90-110页

作者： Wenying Xu Jie Wang Xin-Ni Li Jingxue Liang Lu Song Yi Wu Zhenguo Liu Bomin Sun Wei-Guang Li Department of Rehabilitation Medicine Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Department of Neurosurgery Center for Functional NeurosurgeryRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Neurology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Ministry of Education-Shanghai Key Laboratory for Children’s Environmental Health Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

Deep brain stimulation(DBS)is a well-established and effective treatment for patients with advanced Parkinson’s disease(PD),yet its underlying mechanisms remain ***,primarily conducted in animal models,provides a unique approach that allows cell type-and projection-specific modulation that mirrors the frequency-dependent stimulus effects of ***-DBS research in animal models plays a pivotal role in unraveling the neuronal and synaptic adaptations that contribute to the efficacy of DBS in PD ***-induced neuronal responses rely on a complex interplay between the distributions of presynaptic inputs,frequency-dependent synaptic depression,and the intrinsic excitability of postsynaptic *** orchestration leads to conversion of firing patterns,enabling both antidromic and orthodromic modulation of neural *** these mechanisms is vital for decoding position-and programming-dependent effects of ***,patterned stimulation is emerging as a promising strategy yielding long-lasting therapeutic *** on the neuronal and synaptic adaptations to DBS may pave the way for the development of more enduring and precise modulation *** technologies,such as adaptive DBS or directional electrodes,can also be integrated for circuit-specific *** insights hold the potential to greatly improve the effectiveness of DBS and advance PD treatment to new levels.

关键词： Parkinson’s disease Deep brain stimulation Optogenetics Opto-DBS Synaptic adaptation Orthodromic effects antidromic effects Long-lasting therapeutic effects

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