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Preclinical Evaluation of the antidiabetic effect and Phytochemical HPLC-MS ESI-QTOF Analysis of Sclerocarya birrea (A. Rich) Hoscht Bark of Trunk Aqueous Extract in Alloxan-Induced Diabetic Wistar Rat

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Pharmacology & Pharmacy 2024年第11期15卷 364-387页

作者： Ida Valerie Yasmina Ga San Nintie Traoré Lazare Belemnaba Windingoudi Rimwagna Christian Ouedraogo Boukaré Kaboré Rémy Kindanloun Bationo Bonéwendé Mohamed Belemlilga Souleymane Compaoré Wendinmi Bertrand Florent Goumbri Salfo Ouedraogo Moumouni Koala Mathieu Nitiéma Unit de Formation et de Recherche en Sciences de la Sant (UFR-SDS) Universit Joseph KI-ZERBO Ouagadougou Burkina Faso Dpartement Mdecine et Pharmacope Traditionnelles - Pharmacie (MEPHATRA-PH) Institut de Recherche en Sciences de la Sant/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouagadougou Burkina Faso Dpartement Substances Naturelles Institut de Recherche en Sciences Appliques et Technologique/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouagadougou Burkina Faso

Introduction: Diabetes is a serious public health problem requiring complex treatment. Numerous ethnopharmacological studies have reported the traditional use of Sclerocarya birrea in managing diabetic patients. This study aims to demonstrate, preclinically, the antidiabetic effects of the aqueous decoction of S. birrea trunk bark. Methods: Phytochemical analysis was performed by HPLC-MS. The effects of the extracts (Sb5 and Sb25) and 0.9% NaCl on the normal blood glucose levels of the animals were determined. Diabetes induction was performed intraperitoneally by administering a single dose of alloxan (150 mg/kg) in normoglycemic rats. The antidiabetic effects of the extracts (Allox + Sb5, Allox + Sb25) and glibenclamide (Allox + Glib5) were determined in Alloxan-induced diabetic animals for four weeks. Results: Interpretation of mass spectra obtained by HPLC-MS allowed the tentative identification of vanillic acid-4-sulfate and rhamnetin in Sb extract. Investigated doses of Sb extract showed an antidiabetic impact similar to the reference, glibenclamide, with a return to normal blood glucose in all treated rats only after 4 days of treatment. Furthermore, Sb extract treatments reduced weight loss in diabetic rats. Sb had no negative impact on the balance of total cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL). Conclusion: The present study demonstrated the antidiabetic efficacy and, to some extent, the beneficial effects of Sb extract on Alloxan-induced diabetic rats’ health. Detection of antidiabetic phytochemicals such as vanillic acid-4-sulfate and rhamnetin would justify this pharmacological property of the aqueous decoction of S. birrea trunk bark.

关键词： Preclinical Study Sclerocarya birrea antidiabetic effect Alloxan HPLC-MS

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Gathering scientific evidence for a new bioactive natural ingredient:The combination between chemical profiles and biological activities of Flueggea virosa extracts

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Food Bioscience 2022年第5期49卷 1254-1264页

作者： Gokhan Zengin Stefano Dall’Acqua Kouadio Ibrahime Sinan Abdullahi Ibrahim Uba Stefania Sut Gregorio Peron Ouattara Katinan Etienne Manoj Kumar Carlos L.Cespedes-Acuna Julio Alarcon-Enos Adriano Mollica Mohamad Fawzi Mahomoodally Department of Biology Science FacultySelcuk UniversityKonyaTurkey Department of Pharmaceutical and Pharmacological Sciences University of PadovaVia Marzolo 535131 PadovaItaly Department of Molecular Biology and Genetics Faculty of Engineering and Natural SciencesKadir Has UniversityIstanbul34083Turkey Laboratoire de Botanique UFR BiosciencesUniversite Felix Houphouet-BoignyAbidjanRepublic of Cote d’Ivoire Chemical and Biochemical Processing Division ICAR-Central Institute for Research on CottonTechnologyMumbai400019India Plant Biochemistry and Phytochemical Ecology Lab Departmento de Ciencias BasicasFacultad de CienciasUniversidad del Bio BioAv.Andres Bello#720ChillanChile Department of Pharmacy University“G.d’Annunzio”of Chieti-Pescara66100ChietiItaly Department of Health Sciences Faculty of Medicine and Health SciencesUniversity of MauritiusReduit80837Mauritius

Flueggea virosa (Roxb. ex Willd.) Royle is a plant with several traditional uses in tropical countries. To study the potential usefulness, extracts from stem barks and leaves of F. virosa were obtained with different solvents. The phytochemical composition was assessed using LC-MS and NMR. Triterpenes, as oleanolic (0.05-88.09 mg/g extract), and ursolic (0.03-94.36 mg/g extract) acids were determined. In addition, ellagic and gallic acid derivatives were present in large concentrations in some of the extracts. Antioxidant (radical scavenging, reduction ability, and metal chelating) and enzyme inhibitory (cholinesterase, tyrosinase, amylase, and glucosidase) effects were assessed by in vitro chemical assays. The methanol extracts and infusions from both parts show higher antioxidant ability when compared with ethyl acetate extracts, and the antioxidant capacity was correlated with the total phenolic contents of the tested extracts. The extracts demonstrate enzyme inhibitory abilities on AChE and BChE, and multivariate approaches allowed for correlating the activities with the presence of triterpenoids (R > 0.8). Furthermore, molecular docking was used to get insights into the interactions between the triterpenoids and the tested enzymes. Together, these results indicate that F. virosa represents a significant source of naturally-occurring bioactive compounds that can be exploited as a new ingredient for the development of novel functional products with promising biological properties.

关键词： Flueggea virosa Triterpenoids Antioxidant Bioactive agents antidiabetic effect

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Recent trends in extraction,identification and quantification methods of Centella asiatica phytochemicals with potential applications in food industry and therapeutic relevance:A review

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Food Bioscience 2022年第5期49卷 282-306页

作者： Soubhagya Tripathy Deepak Kumar Verma Mamta Thakur Nishant Chakravorty Smita Singh Prem Prakash Srivastav Agricultural and Food Engineering Department Indian Institute of Technology KharagpurKharagpur721302West BengalIndia Department of Food Technology School of SciencesITM UniversityGwalior474001Madhya PradeshIndia School of Medical Science and Technology Indian Institute of Technology Kharagpur721302West BengalIndia Department of Nutrition and Dietetics University Institute of Applied Health SciencesChandigarh UniversityChandigarh140413PunjabIndia

Centella asiatica,a pre-historically utilized medicinal herb that is well recognized as a traditional phytotherapeutic substance for treating a variety of ***,its phytochemicals use as a functional component in food and beverage has recently attracted the attentions of food researchers and *** possesses pharmacological value due to the presence of phytochemicals like flavonoids and terpenoids,mainly asiatic acid,asiaticoside,and *** role as a functional component in developing various processed food products and packaging films is continuously being *** improves the micronutrient profile and antioxidant potential of developed food products like noodles,chocolates,soups,pasta,***,comprehensive scientific validation based on clinical trials is inadequate,which impede the perception of health benefits and nutritional importance of *** rich food ***,there is a need to extensively examine the composition of *** active compounds in order to maximise its application in the food processing and preservation ***,the goal of this paper is to investigate into the existing information on the extraction,identification,and quantification of *** phytochemicals,as well as to explore their biological *** potential of *** for developing functional foods and beverages,as well as their processing and preservation to improve human health,is also highlighted.

关键词： Centella asiatica Asiatic acid Phytochemicals Extraction techniques Food applications Anti-cancerous activity antidiabetic effect

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Amelioration of T2DM by modulation of GLP-1 via targeting α-glucosidase using Lycium barbarum polysaccharide in KKAy diabetic mice

Amelioration of T2DM by modulation of GLP-1 via targeting α...

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中国营养学会第十五届全国营养科学大会

作者： Kang Chen Shu Ying Deng Yang Xue He Zhao Chun Chen Zhang Hui Zhen Cai Ningxia Medical University

To investigate modulation of Lycium barbarum polysaccharide(LBP) on GLP-1 by inhibiting α-glucosidase in diabetic mice. Methods Totally 48 KK mice, the innate T2DM mice, were randomly divided into three groups after administrated with special high-fat diet for about one month. Then they were given intragastric administration of normal saline(diabetes model group, DM), LBP(LBP group) and Acar(acarbose group) respectively for 4 weeks. Another 16 C57 BL/6 mice on normal diet were used as the blank control group(NDC). Four weeks later, all mice were sacrificed. Samples in different groups were obtained at four points in four batches at 30, 60, 90 and 120 minutes after the last gastric infusion with starch paste and drugs. α-glucosidase activity in ileum was detected. RT-PCR was applied to identify GCG gene. GLP-1 expression was examined by immunohistochemistry technique. ELISA was used for detection of GLP-1 and DPP-4 concentrations in mouse serum. Results LBP significantly decreased α-glucosidase activity in the intestine of diabetic mice, as well as acarbose(Peffective in maintaining GLP-1 activity, with effects only present for up to 60 min.

关键词： LBP GCG gene GLP-1 α-glucosidase antidiabetic effect

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