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Traditional herbal formula Sini Powder extract produces antidepressantlike effects through stress-related mechanisms in rats

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Chinese Journal of Natural Medicines 2016年第8期14卷 590-598页

作者： WEI Shan-Shan YANG He-Jin Huang Jia-Wen LU Xue-Ping PENG Ling-Fang WANG Qing-Guo School of Basic Medicine Beijing University of Chinese Medicine Department of Drug Screening Yunnan Institute of Materia Medica

Sini Powder(SP), a traditional Chinese herbal formula, has long been used to treat depression in patients, although the underlying mechanisms remain to be elucidated. In the present study, we found that rats treated with SP extract for 7 days showed a significant increase in swimming time and reduction in immobility time in forced swimming test in a dose-dependent manner, without changes in locomotion. These effects could be attributed to SP's modulation of the hypothalamus-pituitary-adrenal axis, because a single pretreatment of SP extract could rescue increased serum corticosterone and plasma adrenocorticotropin levels induced by acute elevated platform stress. A single pretreatment of SP extract could also elevate the m RNA expression of hippocampal glucocorticoid receptors. In conclusion, our results suggest that SP extract may act as an anti-stress medication to produce antidepressant-like effects.

关键词： Sini Powder extract antidepressant-like Hypothalamic-pituitary-adrenal axis Glucocorticoid receptor

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Neuronal nitric oxide synthase contributes to chronic stress-induced depression by suppressing hippocampal neurogenesis

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南京医科大学学报(自然科学版) 2008年第1期 4-4页

作者： Zhou,Q. G. Hu,Y. Hua,Y. Hu,M. Luo,C. X. Han,X. Zhu,X. J. Wang,B. Xu,J. S. Zhu,D. Y Nanjing Med Univ,Sch Pharm,Dept Pharmacol,Nanjing 210029,Peoples R China. Nanjing Med Univ,Key Lab Mammalian Genes,Nanjing,Peoples R China.

Increasing evidence suggests that depression may be associated with a lack of hippocampal neurogenesis. It is well established that neuronal nitric oxide synthase(nNOS)-derived NO exerts a negative control on the hippocampal neurogenesis. Using genetic and pharmacological methods,we investigated the roles of nNOS in depression induced by chronic mild stress(CMS) in mice. Hippocampal nNOS over-expression was first observed 4 days and remained elevated 21 and 56 days after exposure to CMS. The mice exposed to CMS exhibited behavioral changes typical of depression,and impaired neurogenesis in the hippocampus. The CMS-induced behavioral despair and hippocampal neurogenesis impairment were prevented and reversed in the null mutant mice lacking nNOS gene(nNOS-/-) and in the mice receiving nNOS inhibitor. Disrupting hippocampal neurogenesis blocked the antidepressant effect of nNOS inhibition. Moreover,nNOS-/-mice exhibited antidepressant-like properties. Our findings suggest that nNOS over-expression in the hippocampus is essential for chronic stress-induced depression and inhibiting nNOS signaling in brain may represent a novel approach for the treatment of depressive disorders.

关键词： depression hippocampal neurogenesis neuronal nitric oxide synthase nitric oxide stress element-binding protein chronic mild stress ischemia stimulates neurogenesis rat paraventricular nucleus adult dentate gyrus antidepressant-like cell-proliferation anxiolytic-like prefrontal cortex progenitor cells

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