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Journal of Clinical and Nursing Research 2024年第1期8卷 196-208页

作者： Seul Gi Lee So-Young Choi Department of Nursing Gyeongsang National University HospitalJinju 52727Korea College of Nursing Gyeongsang National UniversityJinju 52727Korea

Purpose:This research aimed to identify leading factors that affect nurses’compliance with the safe handling of anticancer ***:Data were collected from 114 nurses working in the university hospital and were analyzed through independent t-test,one-way ANOVA,Pearson’s correlation coefficient,and multiple regression analysis using ***:The average level of compliance with the safe handling of anticancer agents was 3.73±0.33 out of 5 *** safety culture(β=0.40,Panticancer *** explained variance for compliance was 28.3%.Conclusion:To enhance the implementation of safety management for anticancer agents,each institution should strive to support human and material resources and enhance specialization in the workplace safety culture through system *** on the results of this study,we suggest research for the development of a training program for anticancer agent safety management.

关键词： anticancer agents Compliance Knowledge Nurse Safety

In vitro studies of polyethyleneimine coated miRNA microspheres as anticancer agents

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Nano Research 2016年第6期9卷 1609-1617页

作者： Irena Rytblat Ning Wu Huangli Xu Aharon Gedanken Xiukun Lin Bar-Ilan Institute for Nanotechnology and Advanced Materials Department of Chemistry Bar-Ilan University Ramat-Gan 52900 Israel Key Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 26607 I China Department of Pharmacology Capital Medical University Beijing 100069 China

RNA plays important roles as a gene-silencing agent, a therapeutic agent for clinical treatment, and in the differentiation, proliferation, and development of cells. However, RNA is very difficult to work with due to its sensitivity and fragility. Another obstacle in using RNA for gene delivery/silencing is its negative charge, which causes its repulsion by cell membranes, which are also negatively charged. Our recent study showed that miR-125b is upregulated in glioblastoma （GMB） and plays an oncogenic role in GMB cells by promoting cell proliferation and inhibiting apoptosis. Endogenous miR-125b can be blocked by transfection of its antisense RNA molecule, miR-125b antisense （miR-125b-AS）. Thus, miR- 125b-AS can be developed as an RNA-based agent for cancer treatment. However, instability during storage and difficulty in delivery into cells has limited the use of RNA-based therapies thus far. In the current work, we demonstrate a short and simple one-step technique for the preparation of positively charged RNA nanospheres （miR-125b-RNS and miR-125b-AS-RNS） coated with a bioavailable polymer, polyethylenimine （PEI）. These RNA nanospheres are able to penetrate the cell directly without the use of liposomes. Our study confirmed that converting miR-125b and miR-125b-AS into nanospheres is a viable approach for storing RNA. In addition, this study provides evidence that PEI-coated RNA nanospheres have the potential to be used as a novel class of anticancer a^ents.

关键词： nanospheres gene silencing gene delivery polyethylenimine anticancer agents

Novel anticancer agents from plant sources

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中国天然药物 2013年第1期11卷 16-23页

作者： Shah Unnati Shah Ripal Acharya Sanjeev Acharya Niyati Pioneer Pharmacy Degree College Vadodara-390019 India Sun Pharma Advanced Research Centre Vadodara-390020 India ~nstitute of Pharmacy Nirma University Sarkhej-Gandhinagar Highway Ahmedabad-382481 India

植物仍然是新药，新药领先和新化学实体的重要来源。植物基于的药发现主要导致了 anticancer 和反传染的代理人的发展，并且继续在临床的试用贡献新领先。自然产品药在药品的照顾起一个主导的作用。几导出植物的混合物成功地当前在癌症... 详细信息

植物仍然是新药，新药领先和新化学实体的重要来源。植物基于的药发现主要导致了 anticancer 和反传染的代理人的发展，并且继续在临床的试用贡献新领先。自然产品药在药品的照顾起一个主导的作用。几导出植物的混合物成功地当前在癌症治疗被采用。有为药的进一步的改进和开发学习的导出植物的细胞毒素的自然产品的许多类。从关于植物 antitumor 代理人的研究导出的新 anticancer 药将连续地被发现。这评论的基本目的是从药用的植物探索最新发现的 anticancer 混合物的潜力，作为为 anticancer 药开发的领先。在地球附近为研究人员和科学家从他们探索植物并且为新药发现的药用的价值将是有用的。

关键词： Cancer anticancer agents Medicinal plants

Alkylating anticancer agents and their relations to microRNAs

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Cancer Drug Resistance 2019年第1期2卷 1-17页

作者： Bernhard Biersack Organic Chemistry Laboratory University of BayreuthBayreuth 95440Germany

Alkylating agents represent an important class of anticancer *** occurrence and emergence of tumor resistance to the treatment with alkylating agents denotes a severe problem in the clinics.A detailed understanding of the mechanisms of activity of alkylating drugs is essential in order to overcome drug *** particular,the role of non-coding microRNAs concerning alkylating drug activity and resistance in various cancers is highlighted in this *** synthetic and natural alkylating agents,which are approved for cancer therapy,are discussed concerning their interplay with microRNAs.

关键词： Alkylating agents microRNA anticancer agents DNA drug resistance

Discovery of Novel Aromathecin Analogues as Potent anticancer agents by Mitochondrion-Mediated Intrinsic Apoptotic Pathway

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Discovery of Novel Aromathecin Analogues as Potent Anticance...

anticancer Activities and QSAR Study of Novel agents with a Chemical Profile of Benzimidazolyl-Retrochalcone

中国化学会·第十五届全国有机合成化学学术研讨会

作者： Jing-Mei Yuan Kai Wei Nan-Ying Chen Cheng-Xue Pan 苏桂发 State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University 广西师范大学

Natural products have historically been the most important source for discovery of therapeutic *** the ongoing work in our group to identify novel antitumor scaffold based on natural *** aromathecin analogues were designed, synthesized and evaluated for antiproliferative activities against four selected human cancer cell lines(HepG-2, T24, NCI-H460 and MGC-803) and one normal human cell lines(HL-7702) in *** results indicated that most of them exhibited potent anticancer activity with the IC value range from 0.31 to 11.97 μ*** mechanism studies suggested that the potential compound 5b exhibited efficient DNA cleaving ability, resulting in S/G2 phase cell cycle arrest and mitochondria mediated apoptosis which could be further confirmed by the results of mitochondrial dysfunction, reactive oxygen species(ROS) generation, altered Ca levels and the expression levels of correlation *** together, these mechanistic insights indicate that compound 5b could be novel anticancer drug candidates.

关键词： aromathecin analogues mitochondrial mediated apoptosis anticancer agents

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Open Journal of Medicinal Chemistry 2020年第3期10卷 113-127页

作者： Ouattara Mahama Koné Aboudramane Koné Soleymane Collet Sylvain Diomandé Sekou Sissouma Drissa Department of Therapeutic Chemistry and Organic Chemistry UFR SPB FHB University Abidjan C&#244 te d’Ivoire Department of Chemistry UFR Environment Jean LorougnonGuédé University Daloa C&#244 te d’Ivoire Laboratory of Organic Chemistry and Natural Substances UFR SSMT FHB University Abidjan C&#244 te d’Ivoire Chemistry and Interdisciplinarity: Synthesis Analysis Modelling (CEISAM) University of Nantes Nantes France

The present pharmacochemical and modelling work focused on a benzimidazolyl-chalcone series. These previously synthesized compounds were evaluated in vitro for their anticancer activities against a panel of seven human cancer cell lines and normal fibroblasts. Among the new benzimidazole-supported chalcones, nine (9) compounds (compounds 1 - 4, 6 - 8 and compounds 10 and 11) showed promising anticancer activities with IC50s ranging from 0.83 to 2.58 μM. Compounds 2 and 6 with IC50s of 0.83 and 0.86 μM, respectively, were shown to be potent inhibitors of HCT-116 colon cancer cell proliferation. It was therefore necessary, for a development of this new series of chalcones, to establish through a QSAR study, their quantum descriptors according to the DFT calculation method and following the B3LYP/6-31+G (d,p) theory. These descriptive and predictive studies focused on the colon HCT 116 cell line which was found to be more sensitive to the anticancer action of our benzimidazolyl-retrochalcones. QSAR study showed that the electronic energy (Eelec), lipophilicity (logP), chemical softness (S) and chemical hardness (η) of benzimidazolyl-retrochalcones play an important role in inhibiting cancer cell proliferation.

关键词： Retrochalcone Benzimidazole anticancer agents QSAR Quantum Descriptors DFT Method

Identification of a dihydroorotate dehydrogenase inhibitor thatinhibits cancer cell growth by proteomic profiling

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肿瘤学研究(英文) 2023年第6期31卷 833-844页

作者： MAKOTO KAWATANI HARUMI AONO SAYOKO HIRANUMA TAKESHI SHIMIZU MAKOTO MUROI TOSHIHIKO NOGAWA TOMOKAZU OHISHI SHUN-ICHI OHBA MANABU KAWADA KANAMI YAMAZAKI SHINGO DAN NAOSHI DOHMAE HIROYUKI OSADA Biomolecular Characterization Unit Technology Platform DivisionRIKEN Center for Sustainable Resource Science(CSRS)Saitama351-0198Japan Chemical Resource Development Unit Technology Platform DivisionRIKEN Center for Sustainable Resource Science(CSRS)Saitama351-0198Japan Chemical Biology Research Group RIKEN Center for Sustainable Resource Science(CSRS)Saitama351-0198Japan Molecular Structure Characterization Unit Technology Platform DivisionRIKEN Center for Sustainable Resource Science(CSRS)Saitama351-0198Japan Institute of Microbial Chemistry(BIKAKEN) NumazuMicrobial Chemistry Research FoundationShizuoka410-0301Japan Division of Molecular Pharmacology Cancer Chemotherapy CenterJapan Foundation for Cancer ResearchTokyo135-8550Japan Department of Pharmaceutical Sciences University of ShizuokaShizuoka422-8526Japan

Dihydroorotate dehydrogenase(DHODH)is a central enzyme of the de novo pyrimidine biosynthesis pathway and is a promising drug target for the treatment of cancer and autoimmune *** study presents the identification of a potent DHODH inhibitor by proteomic ***-based screening revealed that NPD723,which is reduced to H-006 in cells,strongly induces myeloid differentiation and inhibits cell growth in HL-60 cells.H-006 also suppressed the growth of various cancer *** profiling of NPD723-treated cells in ChemProteoBase showed that NPD723 was clustered with DHODH inhibitors.H-006 potently inhibited human DHODH activity in vitro,whereas NPD723 was approximately 400 times less active than H-006.H-006-induced cell death was rescued by the addition of the DHODH product orotic ***,metabolome analysis revealed that H-006 treatment promotes marked accumulation of the DHODH substrate dihydroorotic *** results suggest that NPD723 is reduced in cells to its active metabolite H-006,which then targets DHODH and suppresses cancer cell ***,H-006-related drugs represent a potentially powerful treatment for cancer and other diseases.

关键词： anticancer agents Differentiating agents Drug target identification

Auranofin and its analogs as prospective agents for the treatment of colorectal cancer

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Cancer Drug Resistance 2022年第1期5卷 1-14页

作者： Lara Massai Damiano Cirri Tiziano Marzo Luigi Messori Department of Chemistry University of FlorenceSesto Fiorentino 50019Italy Department of Chemistry and Industrial Chemistry University of PisaPisa 56124Italy Department of Pharmacy University of PisaPisa 56126Italy CISUP-Centre for Instrumentation Sharing(Centro per l’Integrazione della Strumentazione Scientifica) University of PisaPisa 56126Italy University Consortium for Research in the Chemistry of Metal ions in Biological Systems(CIRCMSB) Bari 70126Italy

Today colorectal cancer(CRC)is one of the leading causes of cancer death *** disease is poorly chemo-sensitive toward the existing medical treatments so that new and more effective therapeutic agents are urgently needed and intensely *** drugs,oxaliplatin in particular,were reported to produce some significant benefit in CRC treatment,triggering the general interest of medicinal chemists and oncologists for metal-based compounds as candidate anti-CRC *** this frame,gold compounds and,specifically,the established antiarthritic drug auranofin with its analogs,form a novel group of promising anticancer *** to its innovative mechanism of action and its favorable pharmacological profile,auranofin together with its derivatives are proposed here as novel experimental agents for CRC treatment,capable of overcoming resistance to platinum *** encouraging results in this direction have already been obtained.A few recent studies demonstrate that the action of auranofin may be further potentiated through the preparation of suitable pharmaceutical formulations capable of protecting the gold pharmacophore from unselective reactivity or through the design of highly synergic drug *** perspectives of the research in this field are outlined.

关键词： Auranofin CRC colorectal cancer metallodrugs anticancer agents gold gold-based drugs

In vitro cytotoxicity and antimicrobial activity of Talaromyces flavus SP5 inhabited in the marine sediment of Southern Coast of India

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Chinese Journal of Natural Medicines 2016年第12期14卷 913-921页

作者： Bibin G.Anand C.K.Navin Thomas S.Prakash Department of Biotechnology Udaya School of Engineering Udaya Nagar Tamil Nadu india Cherraan's Institute of Health Sciences Tamil Nadu India Center for Biologically Inspired Systems Science Department of Biology Indian Institute of Technology Jodhpur Old Residency Road Jodhpur Rajasthan India

Marine sediment samples were collected from the coastal areas of Southern India, particularly in Kanyakumari District. Twenty-eight different fungal strains were isolated. The screening of fungi from marine sediment was done to isolate a potent fungus that can produce bioactive compounds for biomedical applications. Only three strains viz Trichoderma gamsii SP4, Talaromyces flavus SP5 and Aspergillus oryzae SP6 were screened for further studies. The intracellular bioactive compounds were extracted using solvent extraction method. The crude extracts were tested for its anti-microbial and anti-cancer properties and analytically characterized using Gas Chromatography Mass Spectrometry(GC-MS). All the three extracts were active, but the extract from T. flavus SP5 was found to be more active against various human pathogens, viz., Pseudomonas aeruginosa ATCC 27853(17.8 ± 0.1), Escherichia coli ATCC 52922(18.3 ± 0.3), and Candida tropicalis ATCC 750(17.7 ± 0.4). It also exhibited cytotoxic activity against HEp2 carcinoma cell line with the LC_(50) value of 25.7 μg·mL^(-1). The GC-MS data revealed the presence of effective bioactive compounds. These results revealed that the extract from isolated fungus T. flavus SP5 acted as a potent antimicrobial, antifungal, and anticancer agent, providing basic information on the potency of marine fungi towards biomedical applications; further investigation may lead to the development of novel anticancer drugs.

关键词： Marine sediment fungi Bioactive compounds Anti-microbial anticancer agents

A Systematic Review of anticancer Effects of Radix Astragali

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Chinese Journal of Integrative Medicine 2016年第3期22卷 225-236页

作者： Yeehong Jung Uimin Jerng Sookyung Lee Department of Clinical Oncology College of Korean MedicineKyung Hee University Hospital at Gangdong Clinical Research Division Korea Institute of Oriental Medicine

Objective： To review the anticancer effects of Radix astragali （RA）, one of the most commonly used herbs to manage cancer in East Asia, and its constituents and to provide evidence of clinical usage through previously performed clinical studies. Methods： Preclinical and clinical studies related to the anticancer effects of RA were searched from inception to November 2013 in electronic databases. Two reviewers independently investigated 92 eligible studies, extracted all the data of studies and appraised methodological quality of clinical trials. The studies were categorized into in vitro and in vivo experimental studies and clinical studies, and analyzed by saponins, polysaccharides, and flavonoids of RA constituents, RA fraction, and whole extract. Results： In preclinical studies, RA was reported to have tumor growth inhibitory effects, immunomodulatory effects, and attenuating adverse effects by cytotoxic agents as well as chemopreventive effects. Saponins seemed to be the main constituents, which directly contributed to suppression of tumor growth through the activation of both intrinsic and extrinsic apoptotic pathway, modulation of intracellular signaling pathway, and inhibition of invasion and angiogenesis. Flavonoids suppressed tumor growth through the similar mechanisms with saponins. Polysaccharides showed immunomodulatory effects, contributing tumor shrinkages in animal models, despite the low cytotoxicity to cancer cells. Most of the clinical studies were performed with low evidence level of study designs because of various limitations. RA whole extracts and polysacchaddes of RA were reported to improve the quality of life and ameliorate myelosuppression and other adverse events induced by cytotoxic therapies. Coaclusion： The polysaccharides, saponins, and flavonoids of RA, and the whole extract of RA have been widely reported with their anticancer effects in preclinical studies and showed a potential application as a adjunctive cancer therapeutics with t

关键词： Radix astragali anticancer agents cancer systematic review