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Potential of antibody-dependent cellular cytotoxicity in Acute and Recovery Phases of SARS-CoV-2 Infection

Infectious Diseases & Immunity 2022年第2期2卷 74-82页

作者： Tingting Cui Mingzhu Huang Xiaoling Su Zhengfang Lin Jiaying Zhong Xiaoyun Yang Zhongfang Wang The State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510180China

Background:Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has caused a global pandemic that has resulted in millions of *** researchers have reported the existence of neutralizing antibodies and viral T cell immunity against SARS-CoV-2,little is known about the presence of antibody-dependent cellular cytotoxicity(ADCC)and its role in combating SARS-CoV-2 ***:Nineteen acute COVID-19 patients at the First Affiliated Hospital of Guangzhou Medical University from January to February,2020 and 55 recovery COVID-19 patients at the Second Peoples Hospital of Changde City from February,2020 to February,2021 were recruited in this *** plasma samples were collected.A virus-specific ADCC assay was performed to study the COVID-19 plasma *** correlations between ADCC and total IgG titer,including anti-RBD,anti-N,and neutralizing antibody titer were ***:A high level of ADCC with 0.86%of IFN-g+CD107a+NK cells induced by anti RBD antibodies and with 0.54%of IFN-g+CD107a+NK cells induced by anti N antibodies was *** activity peaked at 3 weeks after disease onset with 1.16%and 0.63%of IFN-g+CD107a+NK cells induced by anti RBD and anti N antibodies respectively,declined to 0.32%and 0.32%of IFN-g+CD107a+NK cells respectively after more than 2 months,and persisted for 12 months after disease *** ADCC did not aggravate the severity of COVID-19 in terms of sequential organ failure assessment,although ADCC decreased with the age of COVID-19 ***,ADCC response is not correlated with neutralizing antibody titer or total IgG titers against S protein RBD and N protein in acute *** in recovered patients showed a significant correlation with anti RBD IgG titer(R2=0.33,P<0.001).Conclusion:Antibodies from COVID-19 patients against the N protein and S protein RBD domains could stimulate high levels of ADCC *** results provide evidence that vaccination should not only foc

关键词： antibody-dependent cell cytotoxicity Aged immunity Anti-viral immunity SARS-CoV-2 Severity

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