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No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2

Cellular & Molecular Immunology 2022年第3期19卷 449-452页

作者： Prerna Arora Amy Kempf Inga Nehlmeier Luise Graichen Martin S.Winkler Martin Lier Sebastian Schulz Hans-Martin Jäck Stefan Pöhlmann Markus Hoffmann Infection Biology Unit German Primate CenterKellnerweg 437077GöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenWilhelmsplatz 137073GöttingenGermany Department of Anesthesiology University of Göttingen Medical CenterGeorg-August University GöttingenRobert-Koch-Straße 4037075GöttingenGermany Division of Molecular Immunology Department of Internal Medicine 3Friedrich-Alexander University Erlangen-NürnbergGlückstraße 691054ErlangenGermany

Since the beginning of the COVID-19 pandemic,multiple SARS-CoV-2 variants have *** some variants spread only locally,others,referred to as variants of concern,disseminated globally and became drivers of the *** SARS-CoV-2 variants harbor mutations relative to the virus circulating early in the pandemic,and mutations in the viral spike(S)protein are considered of particular relevance since the S protein mediates host cell entry and constitutes the key target of the neutralizing antibody *** a consequence,mutations in the S protein may increase SARS-CoV-2 infectivity and enable its evasion of neutralizing ***,mutations in the S protein can modulate viral transmissibility and pathogenicity.

关键词： SARS-CoV-2 AY.4.2 Delta Host cell entry antibody evasion

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The humoral and cellular immune evasion of SARS-CoV-2 Omicron and sub-lineages

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Virologica Sinica 2022年第6期37卷 786-795页

作者： Tiandan Xiang Junzhong Wang Xin Zheng Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Joint International Laboratory of Infection and Immunity Huazhong University of Science and TechnologyWuhan 430022China

The recently discovered SARS-CoV-2 variant Omicron(B.1.1.529) has rapidly become a global public health *** substantial mutations in the spike protein in this new variant have raised concerns about its ability to escape from pre-existing immunity established by natural infection or vaccination. In this review, we give a summary of current knowledge concerning the antibody evasion properties of Omicron and its subvariants(BA.2, BA.2.12.1,BA.4/5, and BA.2.75) from therapeutic monoclonal antibodies and the sera of SARS-CoV-2 vaccine recipients or convalescent patients. We also summarize whether vaccine-induced cellular immunity(memory B cell and T cell response) can recognize Omicron specifically. In brief, the Omicron variants demonstrated remarkable antibody evasion, with even more striking antibody escape seen in the Omicron BA.4 and BA.5 sub-lineages. Luckily, the third booster vaccine dose significantly increased the neutralizing antibodies titers, and the vaccine-induced cellular response remains conserved and provides second-line defense against the Omicron.

关键词： SARS-CoV-2 Omicron Vaccine antibody evasion Cellular immunity

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