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COLORIMETRIC DETECTION OF CARBENICILLIN USING CATIONIC POLYTHIOPHENE DERIVATIVES

Chinese Journal of Polymer Science 2013年第11期31卷 1484-1490页

作者： Gui-ying Liu Min-huan Lan 刘卫敏 Jia-sheng Wu Jie-chao Ge Hong-yan Zhang Department of Pediatrics Beijing Anzhen HospitalCapital Medical University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences

A water-soluble, polythiophene-based colorimetric sensor was designed for selective and sensitive detection of carbenicillin in HEPES buffer solution. Quaternized quinine was linked to thiophene through bis-functionality benzyl group, which can interact with carbenicillin via electrostatic interaction and geometric match effect. The sensor exhibited a colorimetric signal change upon the addition of carbenicillin because of the formation of more nonplanar structures. However, the addition of other beta-lactarn antibiotics.or dicarboxylic acids into the sensor solution caused no obvious changes in absorbance intensity ratio. This result may be attributed to the cavity formed by the semi-rigid framework of PTQ2, which is suitable for the special binding with carbenicillin. This novel sensor can effectively distinguish carbenicillin from other beta-lactam antibiotics.and has a wide linear range response in HEPES buffer solution. Linear calibration curves are obtained with 0 to 18 μmol/L of HEPES buffer solution, with a limit of detection of 0.54μmol/L.

关键词： Polythiophene Colorimetric sensor antibiotics.

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Solid-Phase Total Synthesis of 1-β-Methylcarbapenem

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Chinese Chemical Letters 2003年第1期14卷 6-8页

作者： Ming LEI Cheng MA Yan Guang WANG Department of Chemistry Zhejiang UniversityHangzhou 310027

A 1-b-methylcarbapenem analogue 6 was synthesized on polystyrene-diethylsilane resin (PS-DES) using 2-azetidinone bearing with 2-oxazolidone chiral auxiliary as starting material.

关键词： Solid-phase synthesis of b-lactam carbapenem antibiotics.

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Etiological study for a case of multi-bacterial synergistic gangrene

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Chinese Science Bulletin 1997年第6期42卷 511-517页

作者： Xu, JG Yang, HM Lai, XH Fu, XL Wu, JM Huang, LB Yu, XJ Wu, YP Wu, YJ Liu, BY Priority Laboratory of Molecular Medical Bacteriology Ministry of Health Institute of Epidemiology and Microbiology Chinese Academy for Preventive Medicine Beijing China Laboratory of Bacteriology Beijing Army General Hospital Beijing China

IN July of 1994, a 13-year old girl from Shandong Province, China, found a dark point on her middle finger of the right hand. She licked it with a needle, and washed clothes with pool water by hands afterwards. Intolerable pain was experienced about 10h later. The gangrene was developed in a week and spread gradually up to the right forearm and two fingers of the left hand. In November of 1994, she visited Beijing Army General Hospital, and radical amputations of the right forearm and two fingers of the left hand were carried out after 3d of

关键词： gangrene anaerobes antibiotics.

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In vitro Sensitivity of Three Bacterial Pathogens of Koi Carp （Cyprynus carpio L.） to Certain antibiotics

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Journal of Agricultural Science and Technology(B) 2012年第1期2卷 93-98页

作者： Algama Dessanayakelage Wasantha Rohine Rajpakshe Kurcheti Pani Prasad Subhas Chandra Mukherjee Kumar Kundan Rajeev Kumar Brahmachari Charandas Tembhurne Meena Neeraj Kumar National Aquatic Resources Research and Development Agency Crow Island Mattakkuliya＇ Colombo 15 Sri Lanka Central Institute of Fisheries Education Seven Bunglows Fisheries University Road Versova Mumbai 400061 India Microbiology Division College of Fisheries Dholi Pusa Samastipur Bihar lndia

Three gram negative bacteria isolated from infected koi carp, Cyprinus carpio L. and screened for sensitivity to thirty antibiotics.by the Bauer disc diffusion method. Bacteria evaluated were Aeromonas hydrophila, Pseudomonas aeruginosa and Edwardseilla tarda. A. hydrophila was resistant to ampicilin, cephalothin, sulphatriad, cefpodoxime and cefoxitin. Highest sensitivity was recorded to Colistin methane sulphonate and Ceftriaxone. High resistance was observed for P. aeruginosa in Kanamysin, Cephalothin, Sulphatriad, Colistin methane sulphonate, Tobramysin, Nitro Furantoin, Cefpodoxime, Cefoxitin and Aztreonam. Highest sensitivity recorded with Moxifloxacin. High resistance was observed in Co-trimoxamole and higher sensitivity performed for E. tarda by Tetracyclin, Cephotaxime, Ciprofloxacin, Norfloxacin, Ofloxacin, Moxifloxacin, Gatifloxacin and Levofloxacin. Out of that highest sensitivity recorded with Moxifloxacin High sensitivity was recorded for Moxifloxacin, Ciprofloxacin, Gatifloxacin, Levofloxacin. By means of antibiotic sensitivity test highest resistance was recorded to P. aeruginosa （MAR index-0.3） and least resistant was recorded to E, tarda （MAR index- 0.033）.

关键词： Koi Carp Aeromonas hydrophila Pseudomonas aeruginosa Edwardseilla tarda antibiotics.

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