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Contribution of the SOS response and the DNA repair systems to norfloxacin induced mutations in ***

Marine Life Science & Technology 2023年第4期5卷 538-550页

作者： Tongtong Lin Jiao Pan Colin Gregory Yaohai Wang Clayton Tincher Caitlyn Rivera Michael Lynch Hongan Long Yu Zhang Institute of Evolution and Marine Biodiversity KLMMEOcean University of ChinaQingdao 266003China Laboratory for Marine Biology and Biotechnology Laoshan LaboratoryQingdao 266237China Department of Biology Indiana UniversityBloomington 47405USA Biodesign Center for Mechanisms of Evolution Arizona State UniversityTempe 85281USA School of Mathematics Science Ocean University of ChinaQingdao 266000China

antibiotic-resistant bacteria severely threaten human *** spontaneous mutations generated by endogenous factors,the resistance might also originate from mutations induced by certain antibiotics,such as the *** antibiotics increase the genome-wide mutation rate by introducing replication errors from the SOS response pathway or decreasing the efficiency of the DNA repair ***,the relative contributions of these molecular mechanisms remain unclear,hindering understanding of the generation of resistant ***,using newly-accumulated mutations of wild-type and SOS-uninducible Escherichia coli strains,as well as those of the strains deficient for the mismatch repair(MMR)and the oxidative damage repair pathways,we find that the SOS response is the major mutagenesis contributor in mutation elevation,responsible for~30–50%of the total base-pair substitution(BPS)mutation-rate elevation upon treatment with sublethal levels of norfloxacin(0~50 ng/mL).We further estimate the significance of the effects on other mutational features of these mechanisms(i.e.,transversions,structural variations,and mutation spectrum)in *** using linear *** SOS response plays a positive role in all three mutational features(mutation rates of BPSs,transversions,structural variations)and affects the mutational *** repair systems significantly reduce the BPS mutation rate and the transversion rate,regardless of whether antibiotics are present,while significantly increasing the structural variation rate in *** results quantitatively disentangle the contributions of the SOS response and DNA repair systems in antibiotic-induced mutagenesis.

关键词： Stress response antibiotic-induced mutagenesis Mutation spectrum Linear model

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