检索结果-南通市图书馆

PHOTO CROSS-LINKED BIODEGRADABLE HYDROGELS FOR ENHANCED VANCOMYCIN LOADING AND SUSTAINED RELEASE

Chinese Journal of Polymer Science 2013年第12期31卷 1697-1705页

作者： Jing-zhe Zhang 肖春生 Jin-cheng Wang Xiu-li Zhuang Xue-si Chen Department of Orthopedics China-Japan Union Hospital of Jilin University Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Science

A series of biodegradable hydrogels based on dextran and poly（L-glutamic acid） were fabricated for effective vancomycin loading and release. The preparation of hydrogels was simply achieved by photo cross-linking of methacrylated dextran and poly（L-glutamic acid）-g-hydroxyethyl methacrylate （PGH） in the presence of photoinitiator 12959. The structures of hydrogels were characterized by FTIR and SEM. The swelling and enzymatic degradation behaviors of hydrogels were examined to be dependent on the poly（L-glutamic acid） content in the hydrogels. The higher content of poly（L-glutamic acid） in the gel, the higher swelling ratio and quicker degradation were observed. More interestingly, the hydrogel with higher PGH ratio showed higher vancomycin （VCM） loading content, which might be due to the electrostatic interaction between carboxylate groups in hydrogel and ammonium group of VCM. In vitro drug release from the VCM-loaded hydrogels in aqueous solution exhibited sustained release of VCM up to 72 h, while the in vitro antibacterial.test based on the VCM-loaded hydrogel showed an efficient Methicillin-Resistant S. aureus （MRSA） inhibition extending out to 7 days. These results demonstrated that the biodegradable hydrogels which formed by in situ photo-cross linking would be promising as scaffolds or coatings for local antibacterial.drug release in tissue engineering.

关键词： Photo cross-linking Hydrogel Vancomycin antibacterial.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis of 4-aryl-1,4-dihydropyridine-porphyrin Compounds

Synthesis of 4-aryl-1,4-dihydropyridine-porphyrin Compounds

引用

中国化学会第27届学术年会

作者： Fei Yao, Hui Wang,﹡Rong-Jin Zeng Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, School of Chemistry and Chemical Engineering Hunan University of Science and Technology,Xiangtan,411201

＜正＞With the increasing number of antibiotic resistant strains of microorganisms, it is extremely important to find alternative treatments for microbial infections. The possibility of using

关键词： porphyrin PDT antibacterial.

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：