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A review of global initiatives to fight antibiotic resistance and recent antibiotics' discovery

Acta Pharmaceutica Sinica B 2016年第6期6卷 552-556页

作者： Arpana Sagwal Chaudhary Intellectual Property Consultant Life Sciences

Data from across the world have shown an overall decline in the antibiotic pipeline and continually rising resistance to all first-line and last-resort antibiotics. The gaps in our knowledge of existing prevalence and mechanisms of antibiotic resistance(ABR) are all too well known. Several decades of antibiotic abuse in humans, animals, and agricultural practices have created health emergency situations and huge socio-economic impact. This paper discusses key findings of the studies conducted by several national and international collaborative organizations on the current state of affairs in ***, a brief overview of the antibacterial agents' discovery in recent years approved by the US FDA is discussed.

关键词： Antibiotic drug resistance antibacterial drug resistance Antimicrobial drugs

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Mass drug administration of antibacterials: weighing the evidence regarding benefits and risks

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Infectious Diseases of Poverty 2022年第3期11卷 87-87页

作者： Robert J.Rolfe Hassaan Shaikh L.Gayani Tillekeratne Division of Infectious Diseases Department of MedicineDuke University School of MedicineDurhamNCUSA 不详

Background: Mass drug administration(MDA)is a strategy to improve health at the population level through widespread delivery of medicine in a *** surveyed the literature to summarize the benefits and potential risks associated with MDA of antibacterials,focusing predominantly on azithromycin as it has the greatest evidence *** body: High-quality evidence from randomized controlled trials(RCTs)indicate that MDA-azithromycin is effective in reducing the prevalence of infection due to yaws and *** addition,RCTs suggest that MDA-azithromycin reduces under-five mortality in certain low-resource settings that have high childhood mortality rates at *** reduction in mortality appears to be sustained over time with twice-yearly MDA-azithromycin,with the greatest effect observed in childrenresistance is also a risk associated with MDA-azithromycin and has been reported for both gram-positive and enteric ***,there is the risk for cross-resistance with other antibacterial agents,especially ***: Evidence shows that MDA-azithromycin programs may be beneficial for reducing

关键词： Mass drug administration Child mortality Under-developed nations antibacterial drug resistance

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