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Nontoxic chemical crosslinked bacterial cellulose-heparin-gelatin composite hydrogel as antibacterial dressing

Journal of Materials Science & Technology 2024年第11期178卷 29-38页

作者： Ruixuan Liu Jingting Cai Nana Qin Kexin Zhang Tongyang Li Hao Luo Dadang Guo State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi'an Jiaotong UniversityXi'an 710049China Northwest Institute for Non-ferrous Metal Research Xi'an 710016China College of fashion and art design Xi'an Polytechnic UniversityXi'an 710048China Frontier Institute of Science and Technology Xi'an Jiaotong UniversityXi'an 710049China.

A hydrogel dressing based on bacterial cellulose(BC),which is grafted with quaternary ammonium func-tional and crosslinked with the gelatin-heparin system,is prepared to provide the features mainly con-cerning softness,high swelling ratio,antibacterial property,and *** innovation of prepa-ration is that the BC is beaten into short-chain scaffolds to improve the efficiency of grafting,which not only simplifies the preparation process but also avoids the biotoxicity caused by the introduction of toxic catalyst such as dimethyl sulfoxide(DMSO)or uncertain toxic side products in long-chain *** electron microscopy(SEM)shows that the QBC/Hep/Gel composite hydrogel possesses a three-dimensional mesh structure with high *** hydrogel shows outstanding water manage-ment performance indicated by the swelling ratio of 1476%,water retention ratio of more than 90%at 120 h,and moisture permeability of 3296 g m^(-2) 24 h^(-1).The antibacterial experiment is implemented with staphylococcus aureus,and the antibacterial effect is represented by an inhibition zone of 3 cm in *** vivo animal experiments suggested that QBC/Hep/Gel could effectively promote epithelial reconstruction,collagen deposition,and angiogenesis in normal wounds,reduce inflammation,and ac-celerate wound *** these results indicate that the proposed QBC/Hep/Gel hydrogel is a potential composite for antibacterial dressing.

关键词： antibacterial dressings Hydrogel dressings Wound healing Cross-linking

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