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Blow‑Spun Si3N4‑Incorporated Nanofibrous dressing with antibacterial,Anti‑Inflammatory,and Angiogenic Activities for Chronic Wound Treatment

引用

Advanced Fiber Materials 2024年第2期6卷 543-560页

作者： Pengchao Ma Chun‑Yi Yang Chengli Li Peilun Hu Fang Yang Jiaju Lu Yin‑Yuan Huang Hui Wu Qiong Wu Yongwei Pan Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced MaterialsSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Orthopedics School of Clinical MedicineBeijing Tsinghua Changgung HospitalTsinghua UniversityBeijing 102218China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China MOE Key Laboratory of Bioinformatics Center for Synthetic and Systems BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China Center for Biomaterials and Regenerative Medicine Wuzhen LaboratoryTongxiang 314500China

The effective and safe healing of chronic wounds,such as diabetic ulcers,presents a significant clinical challenge due to the adverse microenvironment in the wound that hinders essential processes of wound healing,including angiogenesis,inflammation resolution,and bacterial ***,there is an urgent demand for the development of safe and cost-effective multifunctional therapeutic *** nitride,with its distinctive antibacterial properties and bioactivities,shows great potential as a promising candidate for the treatment of chronic *** this study,a silicon nitride-incorporated collagen/chitosan nanofibrous dressing(CCS)were successfully fabricated using the solution blow spinning technique(SBS).SBS offers compelling advantages in fabricating uniform nanofibers,resulting in a three-dimensional fluffy nanofibrous scaffold that creates an optimal wound healing *** blow-spun nanofibrous dressing exhibits excellent hygroscopicity and breathability,enabling effective absorption of wound ***,the incorporated silicon nitride within the fibers triggers surface chemical reactions in the aqueous environment,leading to the release of bioactive ions that modulate the wound ***,the CCS demonstrated exceptional capabilities in absorbing wound exudate,facilitating water vapor transmission,and displaying remarkable antibacterial properties in vitro and in a rat infected wound model(up to 99.7%,4.5×10^(7)CFU/cm^(2)for Staphylococcus aureus).Furthermore,the CCS exhibited an enhanced wound closure rate,angiogenesis,and anti-inflammatory effects in a rat diabetic wound model,compared to the control group without silicon nitride incorporation.

关键词： Chronic wound antibacterial dressing Silicon nitride Solution blow spinning Angiogenesis

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