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Nanotherapeutics for regeneration of degenerated tissue infected by bacteria through the multiple delivery of bioactive ions and growth factor with antibacterial/angiogenic and osteogenic/odontogenic capacity

引用

Bioactive Materials 2021年第1期6卷 123-136页

作者： Ahmed El-Fiqi Nandin Mandakhbayar Seung Bin Jo Jonathan C.Knowles Jung-Hwan Lee Hae-Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan31116Republic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan31116Republic of Korea Glass Research Department National Research CentreCairo12622Egypt Division of Biomaterials and Tissue Engineering UCL Eastman Dental Institute256 Grays Inn RoadLondonWC1X 8LDUK The Discoveries Centre for Regenerative and Precision Medicine UCL CampusLondonUK Department of Biomaterials Science School of DentistryDankook UniversityCheonan31116Republic of Korea UCL Eastman-Korea Dental Medicine Innovation Centre Dankook UniversityCheonan31116Republic of Korea

Therapeutic options are quite limited in clinics for the successful repair of infected/degenerated *** the prevalent treatment is the complete removal of the whole infected tissue,this leads to a loss of tissue function and serious *** the dental pulp infection,as one of the most common dental problems,was selected as a clinically relevant case to regenerate using a multifunctional nanotherapeutic *** this,a mesoporous bioactive glass nano-delivery system incorporating silicate,calcium,and copper as well as loading epidermal growth factor(EGF)was designed to provide antibacterial/pro-angiogenic and osteo/odontogenic multiple therapeutic ***-functionalized Cu-doped bioactive glass nanospheres(Cu-BGn)were prepared to be 50–60 nm in size,mesoporous,positive-charged and *** Cu-BGn could release bioactive ions(copper,calcium and silicate ions)with therapeutically-effective *** Cu-BGn treatment to human umbilical vein endothelial cells(HUVEC)led to significant enhancement of the migration,tubule formation and expression of angiogenic gene(*** endothelial growth factor,VEGF).Furthermore,the EGF-loaded Cu-BGn(EGF@Cu-BGn)showed pro-angiogenic effects with antibacterial activity against ***,a pathogen commonly involved in the pulp *** note,under the co-culture condition of HUVEC with ***,the secretion of VEGF was *** addition,the osteo/odontogenic stimulation of the EGF@Cu-BGn was evidenced with human dental pulp stem *** local administration of the EGF@Cu-BGn in a rat molar tooth defect infected with *** revealed significant in vivo regenerative capacity,highlighting the nanotherapeutic uses of the multifunctional nanoparticles for regenerating infected/damaged hard tissues.

关键词： Nanotherapeutics Mesoporous bioglass nanospheres Copper ion/Growth factor antibacterial/angiogenesis Osteogenesis/odontogenesis

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