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EFFECT OF COPPER IMPLANTATION ON antibacterial activity OF AUSTENITIC STAINLESS STEEL

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Acta Metallurgica Sinica(English Letters) 2004年第6期17卷 870-875页

作者： J.Xiong B.F.Xu H.W.Ni P.Y.Xiong Z.G.Dan SchoolofMaterialandMetallurgy WuhanUniversityofScienceandTechnologyWuhan430081China SchoolofMedicineScience WuhanUniversityofScienceandTechnologyWuhan430081China

antibacterial activity has been studied by copper ion implantation into 0Cr18Ni9 stainless steel. Ions extracted from a metal vapor vacuum arc (MEVVA) are sourced with 60-100keV energy and a dose range (0.2-2.0)×1017 ions cm-2. Saturation doses, surface concentration were calculated and the relationships between energy, dose and antibacterial activity were analyzed. Novel phases such as Fe4Cu3 and Cu0.81Ni0.19 were found after copper implantation by X-ray diffraction. The novel phases, effects on antibacterial activity have been investigated. The results show that saturation dose varies with the ions' energy. antibacterial activity has close relation with copper,s concentration in implanted layer and Cu-rich phase.

关键词： stainless steel copper ion implantation saturation dose concentration in implanted layer antibacterial activity

Investigation of antibacterial activity of Two Kinds of Novel Schiff Bases on Escherichia coil by Microcalorimetry

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Chinese Journal of Chemistry 2006年第10期24卷 1295-1300页

作者：朱军成刘义黄伟国周博殷俊 Department of Chemical Biology College of Chemistry and Molecular Sciences Wuhan University Wuhan Hubei 430072 China Department of Chemistry and Centre for Advanced Luminescence Materials Hong Kong Baptist University Waterloo Road Kowloon Tong Hong Kong China

The microcalorimetric method was used to study the antibacterial activity of two newly synthesized Schiff base compounds （H2L3＇ and H2L3） on Escherichia coli, trying to obtain the action on both of multiplying bacteria and non-multiplying bacteria at one experiment. The metabolic power-time curves of the bacteria treated with the compounds were obtained, and the thermokinetic parameters were analyzed, from which the antibacterial activities of these compounds were evaluated. The results showed that both of the two compounds have good activity on aerobic multiplying metabolism of E. coli, with the value of ICso 75.8 and 168.8 mg/L respectively, but have not effective action on fermentation metabolism of E. coli. The action of the compounds on the non-multiplying metabolism was investigated by taking the heat output of E. coli in the stationary phase as the guideline of the activity. The value of MSCso （minimum stationary-cidal concentration 50） of them is 118 and 187.5 mg/L, respectively. So, H2L^3 has stronger antibacterial action on E. coli than H2L^3 either for multiplying bacteria or non-multiplying bacteria, and their activity on the aerobic multiplying bacteria of E. coil is mainly shown. It does strongly suggest that the calorimetric method should play an important role in the fight against the drug-resistant bacteria.

关键词： microcalorimetric method Schiff base antibacterial activity non-multiplying multiplying

Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain

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Chinese Chemical Letters 2016年第2期27卷 235-240页

作者： Chen-Yu Ling Yun-Liang Tao Wen-Jing Chu Hui Wang Hai-Dong Wang Yu-She Yang State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences School of Petrochemical Engineering Changzhou University Department of Microbiology China Pharmaceutical University

A series of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain have been designed and synthesized. In vitro antibacterial activity evaluation showed that most of the derivatives exhibited potent antibacterial activity against drug resistant Gram-positive strains. Compounds 12 a, 12 d, and 28 are the most active derivatives in this series, displaying activity comparable to that of retapamulin and BC-3781. As the metabolic stability of this series is not satisfactory, further modifications are going on to improve their pharmacokinetic profile.

关键词： Multi-drug resistant bacteria Pleuromutilin 4H-Pyran-4-one antibacterial activity

Improvement of mechanical properties, microscopic structures, and antibacterial activity by Ag/ZnO nanocomposite powder for glaze-decorated ceramic

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Journal of Advanced Ceramics 2017年第3期6卷 269-278页

作者： Qian ZHANG Lv Si XU Xiaoyan GUO College of Chemical Engineering Huaqiao University Xiamen China

With the increase in the international trade of ceramics, improvement in the physical and chemical properties of ceramics has become a market demand in recent years. The addition of nanomaterials in glaze can simultaneously improve the mechanical and corrosion resistance properties of ceramics. In this study, the effect of nano-sized Ag/ZnO in glazed ceramic was investigated considering the hardness, whiteness, and microscopic structures of the products. Results showed that the Ag/ZnO nanocomposite powder significantly affects the performance of glaze. Glaze hardness reached the highest value (96.6 HV) at the low sintering temperature of 1130 °C with the addition of 10% Ag/ZnO nanocomposite powder. Furthermore, the Ag/ZnO nanocomposite powder improved crack resistance and whiteness. Ag as AgO and Ag2O in the glaze was effective for antibacterial activity of ceramic. In addition, the Ag/ZnO nanocomposite powder could also promote the shrinkage of bubbles in the glaze layer and smooth the glaze. These results indicated that the nanoparticles could act as an active center for melting raw materials, which is crucial for ceramic properties.

关键词： Ag/ZnO nanocomposite powder sintering temperature performance microstructure antibacterial activity

Synthesis and antibacterial activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety

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Chemical Research in Chinese Universities 2018年第1期34卷 51-56页

作者： XU Boxuan DING Xiudong WU Yachuang CUI Lei QIAN Ping WANG Di ZHAO Yanfang Key Laboratory of Structure-based Drug Design and Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 P. R. China Department of Clinical Laboratory the 309th Hospital of PLA Beijing 100091 P. R. China

A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of ^1H NMR and MS spectra. All target compounds were evaluated for their in vitro antibacterial activities against *** 29213, methicillin-resistant Staphylococcus aureus（MRSA） and vancomycin-resistant Enterococcus（VRE） by minimum inhibitory concentration（MIC） assay. Most of them exhibited antibacterial activity against S. au 29213, MRSA and VRE. Among them, compounds 10e and 10f displayed better activity than the control.

关键词： Oxazolidinone derivative antibacterial activity Linezolid Ranbezolid

Synthesis, Crystal Structure and antibacterial activity of Two Hydrazones Derived from 2-Fluorobenzhydrazide

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Chinese Journal of Structural Chemistry 2013年第1期32卷 142-148页

作者：潘晓秋黄珊珊王飞樊晖冷辉张厚利刁云鹏 College of Pharmacy Dalian Medical University Liaoning University of Traditional Chinese Medicine

Two new Schiff base benzoyl hydrazone compounds, C14H10FN3O3 （Ⅰ） and C14H10F2N2O （Ⅱ）, have been synthesized and characterized by elemental analysis, IR, UV and X-ray single-crystal diffraction. Both compounds crystallize in monoclinic, space group P21/c with a = 7.0514（14）, b = 25.928（5）, c = 7.7099（15）, β = 111.823（2）°, V = 1308.6（4）3, Z = 4, C14H10FN3O3, Mr = 287.25, Dc = 1.458 g/cm3, μ（MoKα） = 0.115 mm-1, F（000） = 592, the final R = 0.0841 and wR = 0.2489 for 1901 observed reflections （I 2σ（I）） for I; a = 11.232（3）, b =12.735（4）, c = 8.612（2） , β = 90.869（3）°, V = 1231.7（6）3, Z = 4, C14H10F2N2O, Mr = 260.24, Dc = 1.403 g/cm3, μ（MoKα） = 0.111 mm-1, F（000） = 536, the final R = 0.0453 and wR = 0.1085 for 1317 observed reflections （I 2σ（I）） for Ⅱ. The antibacterial activities of both compounds against two bacteria were first studied and one compound showed considerable antibacterial activity against K. Pneumonia and S. aureus.

关键词： Schiff base hydrazone crystal structure antibacterial activity

Colorimetric Assay to Determine In Vitro antibacterial activity Against Clinical Isolates： Enhanced activity in Damaged Chinese Masson Pine Needles

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Journal of Integrative Plant Biology 2006年第9期48卷 1034-1046页

作者： Guijun Dong Weidong Pan Tao Zheng Xianghui Liu Gongshe Liu Key Laboratory of Photosynthesis and Environmental Molecular Physiology Institute of Botany the Chinese Academy of Sciences Beijing 100093 China Graduate University of the Chinese Academy of Sciences Beijing 100039 China Bioelectromagnetic Laboratory Institute of Electrical Engineering the Chinese Academy of Sciences Beijing China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology the Chinese Academy of Sciences Beijing 100080 China

A colorimetric assay for antibacterial susceptibility testing of clinical isolates （Escherichia coli, Pseudomonas aeruginosa, Shigella dysenteriae, Staphylococcus aureus, Bacillus cereus, and Streptococcus pneumoniae） is described based on the reduction of a novel tetrazolium salt, 3-（4,5-dimethylthiazol-2-yl）-5-（3-carboxymethoxyphenyl）-2-（4-sulfophenyl）-2Htetrazolium （MTS）, in the presence of phenazine methosulfate （PMS） as an electron-coupling agent. The combination of 200 μg/mL MTS with 25 μmol/L PMS resulted in production of large amounts of formazan within 1 h of exposure. In this setting, fractions extracted from Chinese Masson pine （Pinus massoniana Lamb.） needles damaged by the pine caterpillar Dendrolimus punctatus Walker were found to have enhanced levels of antibacterial activity. These fractions, which were designated ＂Master＂, ＂Technique＂, and ＂Strength＂, were isolated and identified by reverse-phase C18 cartridge concentration, gel filtration, and affinity chromatography. Two fractions purified from healthy and undamaged needles were designated H1 and H2, respectively. For all test bacteria species. Technique produced the lowest minimal inhibitory concentrations （MICs）, ranging from 2 to 32 μg/mL, and H2 produced the highest values, with four of the six M ICs being higher than 128 μg/mL. We found that the Rmax model fitted the data well in that the r^2 ranged between 0.87 and 0.96 （median, 0.92） and no statistically significant deviations from the model were found （P= 0.23）. The median coefficient of variation of the log RC50 values and the slope m of the fitted model for all six strains among the replicates were 38 and 41%, respectively. In the course of the investigation, the physiological and functional factors involved in pest damage to plants were also explored. In summary, the MTS-PMS colorimetric assay has advantages over existing methods for the examination of antibacterial activity, and could be developed further such that it would be suitable

关键词： antibacterial activity clinical isolate colorimetric assay Masson pine needle tetrazolium salt

Preparation of Gallic Acid-chitosan Copolymer and Its antibacterial activity against Staphylococcus Aureus and Escherichia Coli

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Journal of Wuhan University of Technology(Materials Science) 2021年第6期36卷 934-941页

作者：颜春潮肖锋 QIU Tong ZHANG Xueqiong ZHAN Siwen LU Mengli 杨梦佳张娟 College of Pharmacy Hubei University of Chinese MedicineWuhan 430065China Department of Pharmacy Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430060China School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China Maternal and Child Health Hospital of Hubei Wuhan 430070China

To synthesize three different grafting ratios of gallic acid(GA)-chitosan(CS)copolymer by a free radical mediated grafting method,which is further applied to the field of antibacterial materials,crosslinking structures of the compound GA-CS copolymer were characterized,fully indicating that gallic acid is resoundingly grafted onto *** grafting ratios of three copolymers GA-CS are 45.71%(Ⅰ),36.12%(Ⅱ),and 18.96%(Ⅲ)were determined by UV-Vis *** minimum inhibitory concentrations of three GA-CS copolymers are 30μg/mL against Escherichia coli and are ranged from 250 to 550μg/mL against Staphylococcus *** counting viable bacterial colonies,it can be found that antibacterial property is preferable by increasing the grafting ratio of GA-CS *** of investigation on aforementioned bacteria experiment indicate that the CFU/mL values of GA-CS(Ⅰ,Ⅱ,Ⅲ)are 2.04×10^(6),7.56×10^(6),1.48×10^(7) to Staphylococcus aureus,and 2.96×10^(6),1.01×10^(7),2.14×10^(7) to Escherichia coli after 12 h *** addition,the interaction process between GA-CS copolymer and bacteria can be observed through a transmission electron *** specific manifestation is that the bacterial cell membranes are ruptured after being treated with the copolymer,which causes the cell contents to flow out,and the cell morphology is shrunk and out ofshape.

关键词： gallic acid chitosan antibacterial activity antibacterial material

Sprayed Pickering emulsion with high antibacterial activity for wound healing

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Progress in Natural Science:Materials International 2020年第5期30卷 669-676页

作者： Xieru Bao Jie Wu Guanghui Ma State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences School of Chemical Engineering University of Chinese Academy of Sciences PLA Key Laboratory of Biopharmaceutical Production and Formulation Engineering Institute of Process Engineering Chinese Academy of Sciences Jiangsu National Synergetic Innovation Center for Advanced Materials

Effective treatment of wound injuries can prevent infections and promote healing. In this work, a sprayed Pickering emulsion composed of chitosan nanoparticles, tea tree oil and curcumin was formulated. The shear thinning behaviour allowed this Pickering emulsion to spray even with a high viscosity provided by the aqueous phase containing chitosan nanoparticles. Moreover, the Pickering emulsion could recover to the high viscosity after spraying onto the wounds, leading to the long residence time and intimate contact. In addition, the Pickering emulsion provided a carrier to encapsulate the tea tree oil, which caused sustained-release effects and further strengthened tea tree oil’s antibacterial activity towards the Gram-negative Escherichia coli(E. coli),Gram-positive Staphylococcus aureus(S. aureus) and Gram-positive methicillin-resistant Staphylococcus aureus(MRSA). Besides, this multi-phase system offered a platform to load with hydrophobic curcumin, leading to better synergistic healing effects. Meanwhile, the Pickering emulsion avoided the irritation and toxicity related to surfactants, which was far safer than the classical emulsion especially when used in the defective skin. All these excellent properties endowed this sprayed Pickering emulsion with promising prospects for wound healing.

关键词： Pickering emulsion Wound healing Chitosan nanoparticles High viscosity antibacterial activity