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anti-ulcer potentials of phylum mollusca(tropical snail)slime

Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 23-28页

作者： Nwodo NJ Okonta J M Ezugwu CO Attama AA Faculty of Pharmaceutical Sciences University of NigeriaNsukka410001Enugu State

Objective:The effectiveness of the slimy substance in snail to regenerate and repair damaged areas on it body/shell lead to this ***:The anti-ulcer’property of snail slime extracted from phylur mollusca(tropical snail) from the giant African snail Archachatina marginata(***) was investi gated using histamine,stress and indomethacin-induced *** solubility profile of extract was investiga ted in different solvents and at different *** analysis was carried out to determine the type of constituents present in the slim,while acute toxicity test was carried out to evaluate its profile of toxicity The effect of the snail slim on gastrointestinal motility was investigated in mice,while the guinea pig ileum wa used to study the effect of the extract on contraction produced by acetylcholine and *** snail slim contained copious quantity of protein,with varying amounts of simple sugars,carbohydrates and *** slime was not soluble in most common solvents and increases in temperature,did not appear to increase its sol ***:The result further indicated that although the snail slime exhibited significant(Pulcer induced by stress and histamine,it was most potent against ulcer induced by *** snai slime potently inhibited gastrointestinal movement in mice in a dose-dependent manner;however,it was not a ble to inhibit contraction induced by acetylcholine and histamine in guinea pig ***:The snai mucin possesses potent antiulcer properties without any toxic *** mechanism responsible for the anti-ul cer property may not be postulated with certainty but cytoprotective and anti-spasmodic activities are most likel to be involved.

关键词： anti-ulcer activity Phylum moliusca Snail slime

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The Relationship between antioxidant and anti-ulcer Activities in Saudi Honey Samples Harvested from Various Regions in Different Seasons

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Food and Nutrition Sciences 2013年第8期4卷 131-138页

作者： Nabila Al-Jaber Chemistry Department College of Science King Saud University Riyadh KSA.

The main chemical components of 13 Saudi honey samples (composed of winter and summer honeys) were identified according to anti-ulcer and antioxidant activity by using phytochemical and chromatographic analyses. Phytochemical screening of ethyl acetate and water extracts was used to detect the presence of carbohydrates, flavonoids, amino acids, and phenolic acids. High-performance liquid chromatography (HPLC) of sugar contents was used to detect the presence of galactose in all of the honey samples. The other detected sugars were sucrose, fructose, and arabinose. Fifteen amino acids were detected in all of the honey samples: Prolin is dominant in all of the honey samples. The citric acid and tartaric acids of winter and summer honey were also detected, in addition to faint traces of free oxalic acid. Both samples were tested for amino acids, phenolic compounds, and sugars. The most crucial result derived in this study is the effect of summer honey on ulcers. The anti-ulcer activities were also evaluated, showing that oral administration of the honey samples reduced the intensity of ulcer scores when compared to the control group. Similarly, there was a highly significant reduction in the values of the ulcer indices and areas in rats that received the same sample (P ulcer control rats. Finally, the antioxidant activity of the honey samples was evaluated, revealing a proportional relationship between the anti-oxidant and anti-ulcer activities. The results of this study could be reached that the effectiveness of honey as an anti-ulcer increase with the increasing its antioxidant activities.

关键词： Winter and Summer Honey anti-ulcer antioxidant Flavonoids Amino Acids Phytochemical Analysis

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