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Preventing infective complications in inflammatory bowel disease

World Journal of Gastroenterology 2014年第29期20卷 9691-9698页

作者： Justine Mill Ian C Lawrance Centre for inflammatory Bowel Diseases Fremantle Hospital Department of Medicine and Pharmacology University of Western AustraliaFremantle Hospital

Over the past decade there has been a dramatic change in the treatment of patients with Crohn’s disease and ulcerative colitis, which comprise the inflammatory bowel diseases (IBD). This is due to the increasing use of immunosuppressives and in particular the biological agents, which are being used earlier in the course of disease, and for longer durations, as these therapies result in better clinical outcomes for patients. This, however, has the potential to increase the risk of opportunistic and serious infections in these patients, most of which are preventable. Much like the risk for potential malignancy resulting from the use of these therapies long-term, a balance needs to be struck between medication use to control the disease with minimization of the risk of an opportunistic infection. This outcome is achieved by the physician’s tailored use of justified therapies, and the patients’ education and actions to minimize infection risk. The purpose of this review is to explore the evidence and guidelines available to all physicians managing patients with IBD using immunomodulating agents and to aid in the prevention of opportunistic infections.

关键词： Infection Complications Inflammatory bowel diseases Immunosuppression anti-tumor necrosis factor agents

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