检索结果-南通市图书馆

Poor performance of anti-mitochondrial antibodies for the diagnosis of primary biliary cholangitis in female Colombian patients:A singlecenter study

引用

World Journal of Gastroenterology 2021年第29期27卷 4890-4899页

作者： Valentina Guatibonza-García Paula Valentina Gaete Agustín Pérez-Londoño Danna Kathalina Puerto-Baracaldo Sebastián Antonio Gutiérrez-Romero Carlos O Mendivil Monica Tapias School of Medicine Universidad de los AndesBogotá110111Colombia Section of Endocrinology Department of Internal MedicineFundación Santa Fe de BogotáBogotá110111Colombia Department of Hepatology Fundación Santa Fe de BogotáBogotá110111Colombia

BACKGROUND Primary biliary cholangitis(PBC)is a serious disease that causes significant *** is confirmed with liver biopsy but autoantibodies are frequently used as proxies for *** performance of autoantibodies for the diagnosis of PBC seems to vary widely across *** To assess the diagnostic performance of several autoantibodies for the diagnosis of PBC in Latin American *** We studied 85 female adult Colombians,43 cases with biopsy-confirmed PBC and 42 controls in whom a liver biopsy ruled out *** anti-mitochondrial antibodies(AMAs),anti-smooth muscle antibodies(ASMAs)and anti-nuclear antibodies(ANAs),as well as total immunoglobulin(Ig)M and IgG were determined using immunofluorescence or enzyme-linked immunosorbent assay in all study participants within 1 year of the *** all variables,values analyzed were those closest to the date of the *** with viral or alcoholic hepatitis were *** Mean age at diagnosis was 58.7 years for cases and 56.9 years for controls,and the body mass index was lower among *** cases received ursodeoxycholic acid,while most controls received vitamin ***ögren syndrome and Hashimoto’s thyroiditis were the most frequent autoimmune comorbidities of *** prevalence of AMA positivity among PBC cases was unexpectedly *** sensitivity and specificity values were respectively 44.2%and 76.2%for AMA,74.4%and 38.1%for ANA,14.0%and 73.8%for ASMA,26.7%and 80.0%for IgG,and 57.1%and 85.7%for *** combination of positive AMA plus positive IgM had 91%positive predictive value for *** AMA-negative cases,the most prevalent antibodies were ANA(87.5%).In all,62%of AMA-positive and 84.6%of IgM-positive individuals had fibrosis in their *** AMA positivity was very low among female Latin American patients with *** performance of all antibodies was quite *** results highlight the urgent need for better PBC biomarkers.

关键词： Primary biliary cholangitis antibodies anti-mitochondrial antibodies Latin America anti-smooth muscle antibodies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：