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Phytochemical Screening, Toxicity, Analgesic and anti-pyretic Studies of Aqueous Leaf Extract of <i>Plectranthus barbatus</i>[Andrews. Engl.] in Rats

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Pharmacology & Pharmacy 2019年第4期10卷 205-221页

作者： Joseph O. C. Ezeonwumelu Gloria N. Kawooya Aiyabalu G. Okoruwa Samuel Sunday Dare Jennifer C. Ebosie Ambrose A. Akunne Julius Kihdze Tanayen Bede E. Udechukwu Department of Clinical Pharmacy & Biopharmacy School of Pharmacy Kampala International University Western Campus Ishaka Bushenyi Uganda Kampala International University Complementary and Alternative Medicine Research (KIUCAMRES) Group Western Campus Ishaka Bushenyi Uganda Department of Clinical Pharmacy & Biopharmacy School of Pharmacy Kilimanjaro International University Dar es salaam Tanzania Department of Anatomy Faculty of Biomedical Sciences Kampala International University Western Campus Ishaka Bushenyi Uganda School of Health and Medical Sciences Catholic University in Cameroon Bamenda Cameroon Department of Pharmacology and Toxicology Kampala International University Western Campus Ishaka Bushenyi Uganda

Plectranthus barbatus is a popular tropical perennial plant with a wide variety of traditional medicinal uses in tropical Africa, Hindu, Ayurvedic and traditional medicines of Brazil and China. The whole plant and the leaves have many folkloric uses for diverse ailments including pain, heart disease, convulsions, coughs and colds, asthma, bronchitis and tonsillitis among others. This study investigated the phytochemical components, acute toxicity, analgesic and anti-pyretic activities of the aqueous leaf extract of Plectranthus barbatus locally known as Ekizeera in Uganda. The plant leaves were authenticated, collected and decoction was done according to local method. Phytochemical screening was conducted using methods outlined by Trease and Evans and Harborne to determine the components of the extract. Acute toxicity tests were conducted in rats using modified Lorke’s method to determine the safety of the plant material. Analgesic studies were carried out using both a mechanical method (thermally induced pain by tail-flick) and a chemical method (formalin induced pain) in rats by administering extracts orally at 100, 200 and 400 mg/kg of body weight. The method of Al-Ghamdi, modified for local laboratory setting by Adzu was adopted and used for anti-pyretic test. Decoction yielded 9.9% extract. Phytochemical screening confirmed presence of saponins, tannins, alkaloids, terpenoids and essential oils. Acute toxicity tests revealed no deaths in rats after oral treatment with up to 10,000 mg/kg of extract. Tail-flick test was non-significant (p > 0.05) while formalin-induced pain test demonstrated significant activity (p -tests. anti-pyretic activity was non-significant (p > 0.05) with student t-test. These results suggest that the aqueous leaf extract of Plectranthus barbatus contains specific phytochemicals, has a potent dose dependent analgesic activity, no anti-pyretic activity and can be regarded as a safe medicinal plant to use traditionally, which might further

关键词： Acute Toxicity Analgesic anti-pyretic Plectranthus barbatus Phytochemicals Rats

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Quality evaluation of heat stress treated Radix saposhnikoviae using pharmacokinetic and pharmacologic methods

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Journal of Chinese Pharmaceutical Sciences 2018年第2期27卷 109-115页

作者： Hua Jiang Jingming Yang Ling Cao Guizhi Jia Hongliang Dai Xiangcai Meng College of Pharmacy Heilongjiang University of Chinese Medicine Harbin 150040 China College of Pharmacy Jinzhou Medieal University Jinzhou 121001 China Department of Physiology Jinzhou Medical University Jinzhou 121001 China School of Nursing Jinzhou Medical University Jinzhou 121001 China

The quality of Radix saposhnikoviae（RS） had deteriorated due to the adoption of cultivated plants rather than wild plants. High temperature treatment increases the content of several chromones, however using one or more individual constituents would be difficult to determine the medical quality of RS. In this paper, we used pharmacokinetic and pharmacologic approaches to evaluate the quality of RS. The active constituents were analysed using pharmacokinetic parameters of the chromone derivatives, and the antipyretic, analgesic, and anti-inflammatory effects were evaluated by pyretic animal model, hot plate test, and ear edema model, respectively. Only cimifugin was found in plasma after RS and heat-stress-RS were administered to rats, with a 50.6% increase in AUC0–24 h of cimifugin in the latter. Likewise, more potent anti-pyretic, analgesic, and anti-inflammatory activities were also found in the latter. Exposure of S. divaricata fresh roots to high temperatures enhanced the antipyretic, analgesic, and anti-inflammatory effects of RS by promoting the absorption of cimifugin.

关键词： Radix Saposhnikoviae Chromone Pharmacokinetics anti-pyretic Analgesic anti-inflammatory

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