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anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx

Chinese Journal of Natural Medicines 2022年第6期20卷 421-431页

作者： WANG Lu HU Gui-Zhou LU Yin JIANG Shu-Jun QI Jin SU Hua National Center of Colorectal Disease Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022China Department of Pharmacy Jinling HospitalNanjing 210002China Jiangsu Key Laboratory of TCM Evaluation and Translation Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

pseudo-allergic reactions(PARs)widely occur upon application of drugs or functional foods.anti-pseudo-allergic ingredients from natural products have attracted much attention.This study aimed to investigate anti-pseudo-allergic compounds in licorice.The anti-pseudo-allergic effect of licorice extract was evaluated in rat basophilic leukemia 2H3(RBL-2H3)cells.anti-pseudo-allergic compounds were screened by using RBL-2H3 cell extraction and the effects of target components were verified further in RBL-2H3 cells,mouse peritoneal mast cells(MPMCs)and mice.Molecular docking and human MRGPRX2-expressing HEK293T cells(MRGPRX2-HEK293T cells)extraction were performed to determine the potential ligands of MAS-related G protein-coupled receptor-X2(MRGPRX2),a pivotal target for PARs.Glycyrrhizic acid(GA)and licorice chalcone A(LA)were screened and shown to inhibit Compound48/80-induced degranulation and calcium influx in RBL-2H3 cells.GA and LA also inhibited degranulation in MPMCs and increase of histamine and TNF-a in mice.LA could bind to MRGPRX2,as determined by molecular docking and MRGPRX2-HEK293T cell extraction.Our study provides a strong rationale for using GA and LA as novel treatment options for PARs.LA is a potential ligand of MRGPRX2.

关键词： Glycyrrhiza uralensis anti-pseudo-allergy Glycyrrhizic acid Licorice chalcone A MAS-related G protein-coupled receptor-X2

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