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Asian Pacific Journal of Tropical Biomedicine 2022年第12期12卷 495-503页

作者： Akbar Anaeigoudari Department of Physiology School of MedicineJiroft University of Medical ScienceJiroftIran

Medicinal plants and their ingredients have beneficial effects on human *** sativa is a herbal plant with multiple biological and pharmacological *** studies demonstrated the anti-inflammatory and antioxidant properties of Nigella sativa and its main constituent thymoquinone significantly contributes to the antidepressant and anti-nociception effects of this *** has been reported that thymoquinone may achieve its antidepressant effect by preventing the elimination of brain neurotransmitters affecting depression such as *** role of brain-derived neurotrophic factors in the antidepressant effects of thymoquinone has also been ***,thymoquinone can attenuate pain by upregulation of intracellular signaling pathways related to nitric oxide and K_(ATP)^(+)*** present review summarizes the antidepressant and anti-nociceptive activity of Nigella sativa and its main constituent thymoquinone by searching literature on electronic databases such as PubMed,Web of Science,Scopus,and Google Scholar from the beginning of 2010 until the end of August 2022.

关键词： Nigella sativa Thymoquinone antidepressant anti-nociceptive Depression anti-inflammatory Sickness behaviors Pain

Curculigo recurvata *** exhibits anti-nociceptive and anti-diarrheal effects in Albino mice and an in silico model

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Animal Models and Experimental Medicine 2020年第2期3卷 169-181页

作者： Shabbir Ahmad Mst.Samima Nasrin A.S.M.Ali Reza Nishan Chakrabarty Md.Akramul Hoque Sanjida Islam Mohammad Shah Hafez Kabir Syed Mohammed Tareq A.H.M.Khurshid Alam Md.Areeful Haque Md.Saiful Islam Arman Department of Pharmacy International Islamic University ChittagongChittagongBangladesh Department of Biochemistry&Molecular Biology University of ChittagongChittagongBangladesh Department of Chemistry Wayne State UniversityDetroitMIUSA Department of Pharmacy University of RajshahiRajshahiBangladesh Drug and Herbal Research Centre Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala LumpurMalaysia

Background: Curculigo recurvata(C. recurvata) is an enthnomedicinally important herb reported to have significant medicinal values. The present study aimed to explore the in vivo and in silico anti-nociceptive and anti-diarrheal effects of a C. recurvate rhizome methanol extract(Me-RCR).Methods: The analgesic effects of Me-RCR were assessed using acetic acid-induced writhing and the formalin-induced flicking test. The drugs were administered intraperitoneally(IP) at doses of 200 and 400 mg/kg body weight(bw). anti-diarrheal activity was evaluated by assessing intestinal motility, hypersecretion, and fecal score in mice at oral doses of 200 and 400 mg/kg·bw. Computer facilitated analyses for anti-nociceptive and anti-diarrheal activities of three isolated compounds from C. recurvata were undertaken to identify the best-fit ***: The Me-RCR showed significant(P anti-nociception at the highest dose. The extract inhibited both early and late phases of nociception in the formalin-induced writhing test. In the castor oil-induced diarrhoea model, the extract significantly(P anti-diarrheal compound in the computer-facilitated ***: An extract of the plant C. recurvata

关键词： analgesic anti-diarrheal anti-nociceptive curculigine Curculigo recurvata isocurculigine

Electroacupuncture at Fengchi(GB20) inhibits calcitonin gene-related peptide expression in the trigeminovascular system of a rat model of migraine

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Neural Regeneration Research 2017年第5期12卷 804-811页

作者： Luo-peng Zhao Lu Liu Pei Pei Zheng-yang Qu Yu-pu Zhu Lin-peng Wang Department of Acupuncture and Moxibustion Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing China Beijing University of Chinese Medicine Beijing China The First Affiliated Hospital of Anhui University of Chinese Medicine Hefei Anhui Province China

Most migraine patients suffer from cutaneous allodynia; however, the underlying mechanisms are unclear. Calcitonin gene-related peptide（CGRP） plays an important role in the pathophysiology of migraine, and it is therefore, a potential therapeutic target for treating the pain. In the present study, a rat model of conscious migraine, induced by repeated electrical stimulation of the superior sagittal sinus, was established and treated with electroacupuncture at Fengchi（GB20）（depth of 2–3 mm, frequency of 2/15 Hz, intensity of 0.5–1.0 m A, 15 minutes/day, for 7 consecutive days）. Electroacupuncture at GB20 significantly alleviated the decrease in hind paw and facial withdrawal thresholds and significantly lessened the increase in the levels of CGRP in the trigeminal ganglion, trigeminal nucleus caudalis and ventroposterior medial thalamic nucleus in rats with migraine. No CGRP-positive cells were detected in the trigeminal nucleus caudalis or ventroposterior medial thalamic nucleus by immunofluorescence. Our findings suggest that electroacupuncture treatment ameliorates migraine pain and associated cutaneous allodynia by modulating the trigeminovascular system ascending pathway, at least in part by inhibiting CGRP expression in the trigeminal ganglion.

关键词： nerve regeneration electroacupuncture migraine calcitonin gene-related peptide cutaneous allodynia anti-nociceptive Fengchi trigeminal ganglion neural regeneration

Design and synthesis of 4-(1-(4-chlorobenzyl)-2,3-dioxoindolin-5-yl)-1 -(4-substituted/unsubstituted benzylidene) semicarbazide:Novel agents with analgesic,anti-inflammatory and ulcerogenic properties

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Chinese Chemical Letters 2012年第5期23卷 541-544页

作者： Chinnasamy Rajaram Prakash Sundararajan Raja Govindaraj Saravanan Department of Medicinal Chemistry DCRM Pharmacy CollegeJNTUHAndhra PradeshIndia Department of Pharmaceutical Chemistry GITAM Institute of PharmacyGITAM UniversityVizagAndhra PradeshIndia Medicinal Chemistry Research Laboratory Bapatla College of PharmacyBapatla 522 101Andhra PradeshIndia

A new series of isatin semicarbazide derivatives（7a-7j） were synthesized and characterized by spectroscopic means and elemental *** and anti-inflammatory screening was performed using tail-flick technique and the carrageenan-induced foot paw edema test *** ulcerogenicity was also determined for all the *** of the compounds showed moderate enhancement of the *** the synthesized derivatives,compound 7d showed higher analgesic, antiinflammatory and one-third of ulcer index of the reference drug.

关键词： Isatin anti-nociceptive Schiff base Ulcerogenicity

Pharmacological insights into Chukrasia velutina bark:Experimental and computer-aided approaches

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Animal Models and Experimental Medicine 2022年第4期5卷 377-388页

作者： Israt Jahan Shahenur Alam Sakib Najmul Alam Mohuya Majumder Sanjida Sharmin A.S.M.Ali Reza Department of Pharmacy International Islamic University ChittagongChittagongBangladesh Department of Pharmacy East West UniversityDhakaBangladesh

Background:Chukrasia velutina is an enthnomedicinally used plant reported to have significant medicinal *** present study aimed to explore the pharmacological activities of bark methanol extract using in vitro,in vivo and in silico ***:The study was designed to investigate the pharmacological effects of methanol extract of Chukrasia velutina bark(MECVB)through in vitro,in vivo and in silico *** activity was tested using formalin-i nduced nociception and acetic acid-i nduced writhing assays while the antipyretic effect was tested using yeast-i nduced hyperthermia in mice *** antioxidant effect was tested using the DPPH and reducing power assay and the cytotoxic screening was tested using the brine shrimp lethality *** addition,in silico studies were conducted using computer aided ***:In the acetic acid-i nduced writhing assay,the extract showed 28.36%and 56.16%inhibition of writhing for doses of 200 and 400 mg/kg,***,a dose-dependent formalin-i nduced licking response was observed in both early and late *** yeast-i nduced pyrexia,the MECVB exhibited(pantipyretic *** extract demonstrated an ICvalue of 78.86μg/ml compared with ascorbic acid(IC23.53μg/ml)in the DPPH scavenging *** compounds sitosterol,5,7-dimethoxycoumarin and scopoletin were seen be effective in molecular docking scores against COX-I(2OYE),COX-II(6COX)and human peroxiredoxin 5(1HD2).In ADME/T analysis,5,7-dimethoxycoumarin and scopoletin satisfied Lipinski’s rule of five and thus are potential drug ***:The bark of Chukrasia velutina showed significant analgesic and antipyretic properties and is a potential source of natural anti-oxidative agents.

关键词： anti-nociceptive antioxidant antipyretic Chukrasia velutina cytotoxicity

Effect of SRD-P401 on the Discomfort of Neck and/or Shoulder Stiffness

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American Journal of Plant Sciences 2017年第5期8卷 1065-1076页

作者： Akira Iizuka Maasa Sonoda Ruka Goto Tokunori Matsui Chiaki Kudoh Katsumi Kido Yasuhiro Komatsu Center for Supporting Pharmaceutical Education Daiich University of Pharmacy Fukuoka Japan Clinical Pharmacy Education Center Japan College of Pharmaceutical Science Saitama Japan Sun R and D Institute for Natural Medicines Co. Inc. Tokyo Japan KUDOH CHIAKI Clinic for Neurosurgery & Neurology Tokyo Brain & Spinal Cord Research Institute Tokyo Japan Department of Pharmacognosy Daiich University of Pharmacy Fukuoka Japan

SRD-P401 is a newly developed healthy food supplement which has an anti-inflammatory and analgesic effect. In this report, the effects of SRD-P401 on neck and shoulder stiffness were assessed by an inquiry method in the public field. The stiffness symptoms of all participants were improved after taking SRD-P401. The symptoms of the participants who took 3 g/day and/or 9 g/day of SRD-P401 improved in a week after taking it. Unpleasant adverse effects in stomach and alimentally organs were not found during the test period. SRD-P401 showed the anti-nociceptive effect on the acetic-acid-induces abdominal writhing in rats. The potency was equivalent to aspirin. Moreover, to investigate the ability of the anti-inflammatory effects of SRD-P401, we exerted by inhibiting the Cyclooxygenase (COX) enzyme activity. SRD-P401 and its constituents inhibit the COX activity. The results of this field test indicated SRD-P401 would be a beneficial and useful healthy food supplement for a person with stiffness in neck and/or shoulder.

关键词： Supplement anti-Inflammatory anti-nociceptive SRD-P401

Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol

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Pharmacology & Pharmacy 2015年第2期6卷 75-85页

作者： Ruth Gallily Zhannah Yekhtin Lumir Ondrej Hanus The Lautenberg Center for General and Tumor Immunology The Hadassah Medical School The Hebrew University of Jerusalem Jerusalem Israel Department of Medicinal and Natural Products Institute for Drug Research The Hadassah Medical School The Hebrew University of Jerusalem Jerusalem Israel

Cannabidiol (CBD), a major constituent of Cannabis, has been shown to be a powerful anti-inflammatory and anti-anxiety drug, without exerting a psychotropic effect. However, when given either intraperitoneally or orally as a purified product, a bell-shaped dose-response was observed, which limits its clinical use. In the present study, we have studied in mice the anti-inflammatory and anti-nociceptive activities of standardized plant extracts derived from the Cannabis sativa L., clone 202, which is highly enriched in CBD and hardly contains any psychoactive ingredients. In stark contrast to purified CBD, the clone 202 extract, when given either intraperitoneally or orally, provided a clear correlation between the anti-inflammatory and anti-nociceptive responses and the dose, with increasing responses upon increasing doses, which makes this plant medicine ideal for clinical uses. The clone 202 extract reduced zymosan-induced paw swelling and pain in mice, and prevented TNFα production in vivo. It is likely that other components in the extract synergize with CBD to achieve the desired anti-inflammatory action that may contribute to overcoming the bell-shaped dose-response of purified CBD. We therefore propose that Cannabis clone 202 (Avidekel) extract is superior over CBD for the treatment of inflammatory conditions.

关键词： Cannabis sativa L. Clone 202 Cannabidiol anti-Inflammation anti-nociceptive TNFα

Evaluation of antinociceptive Activity of Methanol Extract from Cleome rutidosperma in Mice

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Chinese Herbal Medicines 2016年第3期8卷 273-279页

作者： Prawej Ansari Mitali Debnath Md.Foyez Ahmad Shofiul Azam Shafia Akther Gazi Md.Mustakim Md.Hamza Naquib Shammy Sarwar 机构 = 'Department of Pharmaceutical Sciences North South University Department of Pharmacy International Islamic University Chittagong Department of Pharmacy Stamford University Bangladesh Department of Pharmaceutical Sciences School of Health and Life Sciences North South University

Objective C/eome rutidosperma （Capparidaceae）, commonly known as ＂Fringed Spider Flower＂, is a medicinal plant found in Southeast Asia. C. rutidosperma is used in folk medicine for diuretic, laxative, analgesic, anti-inflammatory, antipyretic, antimicrobial, anti-oxidant, hypoglycemic, and anthelmintic activities. We have evaluated the anti-nociceptive properties of methanol extract from C. rutidosperma （MECR） in vivo. Methods Thermal method （hot plate test and tail flick test） was induced to judge the anti-inflammatory effect and couple of chemical method also used （formalin induced licking test; writhing test carried by acetic acid） to evaluate analgesic effect. Both of these tests were made over animal models, like mice and rats. Two different doses （1 O0 and 200 mg/kg） were used for each case of test, while morphine sulphate （5mg/kg, ip） was used as reference drug. Results MECR demonstrated the significantly anti-nociceptive activity in the analgesic and anti-inflammatory tests by reducing nociception in mice models （P 〈 0.001）. in the hot-plate and tail-flick tests, MECR significantly elongated the time to response to the thermal stimuli （100 and 200 mg/kg with P 〈 0.05, 0.001）. The remarkable increase in the latency was observed at 90 and 120 min. In acetic acid-induced writhing test and formalin induced licking test for anti-inflammatory activity, MECR at 100 and 200 mg/kg doses exhibited significant （P〈 0.001） reduction of writhing and licking response. Conclusion The anti-inflammatory and analgesic effects of C. rutidosperma propose that this effect may be a result of both peripheral and central mechanisms. Further study is required to ensure the proper mechanism of action as well as the active ingredient.

关键词： anti-nociceptive C/eome rutidosperma hot-plate method tail-flick tests

Protective effects of crude and alkaloidal extracts of Tamarindus indica against acute inflammation and nociception in rats

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Journal of Acute Disease 2017年第2期6卷 78-81页

作者： Ali Audu Jigam Fatima Mahmood Bashir Lawal Department of Biochemistry Federal University of TechnologyPMB 65MinnaNiger StateNigeria

Objective: To investigate the anti-inflammatory and antinociceptive effects of total alkaloids extracted from the leaf of Tamarindus indica (T. indica) in rats. Methods:Acetic acid-induced pain and egg albumin-induced inflammation were used to inspect the anti-nociceptive and anti-inflammatory effects of the crude and alkaloidal extracts of T. indica at doses of 40 and 400 mg/kg, respectively. Sodium diclofenac was used as the control drug. Results:The percentage yields of crude methanol and alkaloidal extracts of T. indicawere 2.85% and 0.98%, respectively. Screening of secondary metabolite of the crude extract revealed the presence of saponins, alkaloids, tannins, steroids, phenols and terpenes, while phlobatannins was not detected. The safe dose and LD50 were 400 and 750 mg/kg for crude methanol extract, respectively, while the safe dose and LD50 of alkaloidal extract were 40 and 57 mg/kg, respectively. The anti-inflammatory and antinociceptive effects of crude methanol extract and alkaloid extract of T. indica were significantly (P anti-inflammatory and antinociceptive activities, thus, supporting its folkloric use for the treatment of these conditions.

关键词： Tamarindus indica anti-inflammatory anti-nociceptive Secondary metabolite