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anti-inflammatory effect of extracts of Dendropanax dentige and Lycopodiastrum casuarinoides on rheumatoid arthritis and their underlying mechanism in rats

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中国药理学与毒理学杂志 2016年第10期30卷 1036-1037页

作者： CHEN Gang LIU Zhi-kai HAN Chen-yun LI Jia-shuang ZOU Yi-ping Key Laboratory of Natural Active Pharmaceutical Constituents of Jiangxi Province Yichun University

OBJECTIVE To investigate the anit-inflammatory effect of extracts of Dendropanax dentiger(Harms)Merr and Lycopodiastrum casuarinoides(Spring)Holub on rheumatoid arthritis(RA)using adjuvant arthritis(AA)rat model and possible *** The AA rat model of RA was induced in adult SparagueDawley(SD)rats by injecting of the adjuvant at base ***-week-old male SD rats were randomly divided into the following groups:normal saline group(blank control),*** decoction group(80g·kg-1·d-1),*** decoction group(80 g·kg·d-1),the total of glucoside Tripterygium(GTT)group(positive control,2 mg·kg-1·d-1).They were administered orally for *** of tissues arthritis rats was observed by H.E *** volume of paw swelling was measured and the arthritis inflammation index was *** expressions of tumor necrosis factor-α(TNF-α)and interlukin-1β(IL-1β)were detected by the ELISA *** addition,previous study has reported that plant-derived mi RNAs play a role for cross kingdom regulatory ***,we also performed RNA-seq technique to identify bioactive mi RNAs via comparative transcriptome analysis between *** and *** Comparing with AA model group,the volume of paw swelling and the arthritis index were increased significantly in the AA rat model group(P<0.01),suggesting that the AA model rats were prepared *** with the AA model group,the volume of paw swelling of *** decoction group,*** decoction group was decreased by 25.2%and 10.3%,respectively,and the arthritis index was decreased by 27.2%and 18.3%,*** with AA model group,TNF-αprotein expression of *** decoction group and *** decoction groups were decreased by 16.3%and 14.7%,and IL-1βprotein expression was decreased by 23.6%,18.9%(P<0.05,P<0.01),***,we found that some plant-derived homologous mi RNAs(such as mi RNA192 and mi RNA30a)associated with cell

关键词： rheumatoid arthrits aqueous extracts of D.dentiger and L.Cauarinoides anti-inflammatory effect miRNA cross-kingdom regulation

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Classic mechanisms and experimental models for the anti-inflammatory effect of traditional Chinese medicine

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Animal Models and Experimental Medicine 2022年第2期5卷 108-119页

作者： Du Hongzhi Hou Xiaoying Guo Yujie Chen Le Miao Yuhuan Liu Dahui Huang Luqi National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesBeijingChina Hubei Provincial Key Laboratory of Traditional Chinese Medicine Resources and Traditional Chinese Medicine Chemistry Hubei University of Chinese MedicineWuhanChina Wuhan Biomedical Research Institute School of MedicineJiang Han UniversityWuhanChina

Inflammation is a common disease involved in the pathogenesis,complications,and sequelae of a large number of related diseases,and therefore considerable research has been directed toward developing anti-inflammatory drugs for the prevention and treatment of these *** Chinese medicine(TCM)has been used to treat inflammatory and related diseases since ancient *** to the re-view of abundant modern scientific researches,it is suggested that TCM exhibit anti-inflammatory effects at different levels,and via multiple pathways with various targets,and recently a series of in vitro and in vivo anti-inflammatory models have been developed for anti-inflammation research in ***,the reported classic mechanisms of TCM and experimental models of its anti-inflammatory effects pro-vide reference points and guidance for further research and development of ***,the research clearly confirms that TCM is now and will continue to be an effective form of treatment for many types of inflammation and inflammation-related diseases.

关键词： anti-inflammatory effect inflammation and related diseases the classical mechanisms the experimental models traditional Chinese medicine

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Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

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Frontiers of Medicine 2012年第2期6卷 195-203页

作者： Liyuan Chen Qifeng Dang Chengsheng Liu Jun Chen Lei Song Xiguang Chen College of Marine Life Sciences Ocean University of ChinaQingdao 266003China Department of Surgery the Commercial Staff&Workers Hospital of QingdaoQingdao 266011China

The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofen by a solid dispersion(SD)*** screening was developed based on drug solubility in carriers in the liquid state to select a suitable water-soluble carrier system for the preparation of *** dissolution of ibuprofen in urea was higher than in PEG4000 or ***,urea was selected as the carrier for the preparation of *** were characterized in terms of dissolution,differential scanning calorimetry(DSC),X-ray diffraction(XRD),scanning electron microscopy(SEM),and Fourier transform infrared(FTIR)*** dispersionbased(SDBT)and conventional(CT)tablets were prepared by the wet granulation *** antiinflammatory effect of SDBT was evaluated using the mouse ear edema test with *** vitro release results indicated that the ibuprofen dissolution rate was improved by the *** characterization results suggested that ibuprofen partly precipitates in crystalline and amorphous forms after SD preparation and that ibuprofen and urea do not *** displayed more significant anti-inflammatory effects than *** dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea SD.

关键词： ibuprofen solid dispersion physical mixture dissolution anti-inflammatory effect

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Quantitative analysis and simulation of anti-inflammatory effect of active components of Paino powder in rats

Quantitative analysis and simulation of anti-inflammatory ef...

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中国药理学会第十次全国学术会议

作者：陈君超李绿金文世梅何迎春刘红霞郑青山上海中医药大学药物临床研究中心计算药物学实验室

关键词： Paino powder active ingredient anti-inflammatory effect drug interactions

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Quantitative analysis and simulation of anti-inflammatory effect of active components of Paino powder in rats

Quantitative analysis and simulation of anti-inflammatory ef...

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第十二届全国数学药理学术大会

作者：陈君超李禄金文世梅何迎春刘红霞郑青山 Department of Pharmacometrics Center for Drug of Clinical ResearchShanghai University of Traditional Chinese Medicine

Objective:To explore different combinations of the active ingredients,including paeoniflorin,naringin,neohesperidin and platycodin-D from Paino powder,responsible for the inhibition of carrageenin-induced edema in rats,and to evaluate the performance of the orthogonal simulation method in quantitative analysis and simulation of the ***:An orthogonal design with 1-level (used) and 2-level(unused) was applied to assign the seven combinations of active *** and saline were set as two *** carrageenin-induced edema in right hind paws of rat was established as acute inflammation *** efficacy indices were expressed by the area under curve (AUC) and peak value of the swelling change(%) over time in’***:Compared with the saline group,the rats in active components combinations showed a significant reduction of AUC and peak value in swelling(Panti-inflammatory effect was from the full four-ingredient *** the four ingredients,naringin showed a dominant contribution to the combination, and paeoniflorin>platycodin-D>naringin in *** are consistent with the results of computer ***:A single component from Paino powder does not exhibit anti-inflammatory effect, but some combinations show the *** strongest effect comes from the full four-ingredient *** orthogonal simulation method is feasible in research of decomposed formula of TCM.

关键词： Paino powder active ingredient anti-inflammatory effect drug interactions

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Experimental Study on the anti-inflammatory effect of Ficus pumila L.

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Medicinal Plant 2020年第4期11卷 26-29页

作者： Chao ZENG Meiyuan LU Tingting MO Bing WU Qingtong LAN The First Affiliated Hospital of Guangxi University of Chinese Medicine Nanning 530023 China Guangxi Food and Drug Evaluation and Inspection Center Nanning 530029 China Liuzhou Chinese Medicine Hospital Liuzhou 545001 China

[Objectives]To study the anti-inflammatory effects of extracts from different parts of Ficus pumila L.[Methods]inflammatory models of xylene-induced ear swelling,glacial acetic acid-induced celiac capillary permeability and carrageenan-induced toe swelling were established to evaluate the effects of extracts from different parts of *** *** *** inflammatory model of ear swelling in mice with bilateral adrenalectomy induced by xylene was established to determine whether its anti-inflammatory effect depends on hypothalamus-pituitary-adrenal axis(HPAA)system.[Results]Compared with the blank control group,except that there was no statistical significance in the low dose group(P>0.05),the high and middle dose groups of extracts from different parts of *** *** significant inhibitory effects on xylene-induced ear swelling in *** high,middle and low dose groups of *** *** could significantly increase the celiac capillary permeability of mice induced by glacial acetic acid,and significantly inhibit the toe swelling induced by *** with the blank control group,the high and middle dose groups of extracts from different parts of *** *** significantly inhibit xylene-induced ear swelling and carrageenan-induced toe swelling in bilateral adrenalectomy mice.[Conclusions]The extracts from different parts of *** *** anti-inflammatory activity,and its anti-inflammatory effect was independent of hypothalamus-pituitary-adrenal axis(HPAA)system.

关键词： Ficus pumila L. anti-inflammatory effect Preliminary study

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Study of Analgesic and anti-inflammatory effects of Lappaconitine Gelata

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Journal of Traditional Chinese Medicine 2009年第2期29卷 141-145页

作者：王英姿肖勇庆张超孙秀梅 College of Chinese Materia Medica Beijing University of Traditional Chinese MedicineBeijing 100102 China China Academy of Traditional Chinese Medicine Beijing 100700 China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250014 China

Objective: To explore the analgesic and anti-inflammatory effects of lappaconitine gelata (LA). Methods: The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate method in the mouse, and the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were used for investigation on the analgesic and anti-inflammatory effects of LA. Results: The writhing response induced by acetic acid, the pain response induced by formaldehyde and hot plate methods was significantly inhibited by LA. In addition, the paw edema induced by egg albumen in the rat and the ear edema induced by xylene in the mouse were all significantly suppressed by LA. Conclusion: LA has the analgesic and anti-inflammatory effects.

关键词： lappaconitine gelata pharmacodynamics analgesic effect anti-inflammatory effect animal test

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Screening of effective Fractions for antitussive and anti-inflammatory effects of Miao Medicine Aspidistra caespitosa

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Agricultural Biotechnology 2021年第5期10卷 98-101,114页

作者： Yongyue GAO Xiangling QU Pu WANG Ying LIN Hai ZHAO The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550003China

[Objectives]This study was conducted to investigate the antitussive and anti-inflammatory effects of Miao medicine Aspidistra caespitosa ***.[Methods]A mouse cough model was made by the SO 2 cough induction method,and the antitussive effects of different extraction fractions of *** were *** inflammation models of acute inflammatory ear swelling in mice caused by xylene,granuloma in mice caused by cotton balls,and footpad swelling in mice caused by carrageenan were made,and the different extraction fractions were used to observe the effects of different extraction fractions on mouse ear swelling,granuloma and footpad *** the levels of interleukin 6(IL-6)and tumor necrosis factor(TNF-a)in the serum of different groups of mice were detected to screen out the extraction fractions of *** with good antitussive and anti-inflammatory activity.[Results]antitussive experiments on mice showed that the water layer extraction fraction,ethyl acetate extraction fraction and petroleum ether extraction fraction of Miao medicine *** could prolong the incubation period of cough in mice and reduce the number of coughs within 2 min to varying degrees,and its different extraction fractions all had different inhibitory effects on mouse ear swelling,granuloma and footpad *** with the blank control group,the different extraction fractions could reduce IL-6,TNF-a and other indicators to different degrees.[Conclusions]Ethyl acetate extraction fraction of *** has good antitussive and anti-inflammatory effects.

关键词： Aspidistra caespitosa antitussive effect anti-inflammatory effect Screening

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CORM-2-entrapped ultradeformable liposomes ameliorate acute skin inflammation in an ear edema model via effective CO delivery

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Acta Pharmaceutica Sinica B 2020年第12期10卷 2362-2373,2440页

作者： Gwan-Yeong Lee Alam Zeb Eun-Hye Kim Beomseon Suh Young-Jun Shin Donghyun Kim Kyoung-Won Kim Yeong-Hwan Choe Ho-Ik Choi Cheol-Ho Lee Omer Salman Qureshi In-Bo Han Sun-Young Chang Ok-Nam Bae Jin-Ki Kim College of Pharmacy Institute of Pharmaceutical Science and TechnologyHanyang UniversityAnsan 15588Republic of Korea Riphah Institute of Pharmaceutical Sciences Riphah International UniversityIslamabad 44000Pakistan Department of Pharmacy Forman Christian CollegeLahore 54600Pakistan Department of Neurosurgery CHA Bundang Medical CenterSchool of MedicineCHA UniversitySeongnam 13496Republic of Korea College of Pharmacy Ajou UniversitySuwon 16499Republic of Korea

The short release half-life of carbon monoxide(CO)is a major obstacle to the effective therapeutic use of carbon monoxide-releasing molecule-2(CORM-2).The potential of CORM-2-entrapped ultradeformable liposomes(CORM-2-UDLs)to enhance the release half-life of CO and alleviate skin inflammation was investigated in the present ***-2-UDLs were prepared by using soy phosphatidylcholine to form lipid bilayers and Tween 80 as an edge *** deformability of CORM-2-UDLs was measured and compared with that of conventional liposomes by passing formulations through a filter device at a constant *** release profile of CO from CORM-2-UDLs was evaluated by myoglobin *** vitro and in vivo anti-inflammatory effects of CORM-2-UDLs were assessed in lipopolysaccharide-stimulated macrophages and TPA-induced ear edema model,*** deformability of the optimized CORM-2-UDLs was 2.3 times higher than conventional ***-2-UDLs significantly prolonged the release half-life of CO from 30 s in a CORM-2 solution to 21.6 ***-2-UDLs demonstrated in vitro anti-inflammatory activity by decreasing nitrite production and pro-inflammatory cytokine ***,CORM-2-UDLs successfully ameliorated skin inflammation by reducing ear edema,pathological scores,neutrophil accumulation,and inflammatory cytokines *** results demonstrate that CORM-2-UDLs could be used as promising therapeutics against acute skin inflammation.

关键词： Carbon monoxide CORM-2 anti-inflammatory effect Ultradeformable liposomes Skin inflammation Ear edema

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Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activities

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Acta Pharmaceutica Sinica B 2017年第4期7卷 491-495页

作者： Yanan Yang Yawen An Wei Wang Ning Du Jinghua Zhang Ziming Feng Jianshuang Jiang Peicheng Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Beijing Centre for Physical and Chemical Analysis Beijing 100089China

Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.

关键词： Lycium chinense Lyciumlignan D Lyciumphenyl propanoid A Structure elucidation anti-inflammatory effect

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