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A rare case of enteropathy-associated T-cell lymphoma presenting as acute renal failure

World Journal of Gastroenterology 2006年第14期12卷 2301-2304页

作者： Milena Bakrac Branka Bonaci Miodrag Krstic Sanja Simic Milica Colovic Institute of Hematology Clinical Center of Serbia Serbia Institute of Allergology and Immunology Clinical Center of Serbia Serbia Institute of Gastroenterology Clinical Center of Serbia Serbia Institute of Nephrology Clinical Center of Serbia Serbia

Enteropathy-associated T-cell lymphoma （EATCL） is a high grade, pleomorphic peripheral T-cell lymphoma usually with cytotoxic phenotypes. We describe a first case of patient with EATCL that is remarkable for its fulminant course and invasion of both kidneys manifested as acute renal failure. The patient was a 23 year old woman with a long history of celiac disease. She was presented with acute renal failure and enlarged mononuclear infiltrated kidneys. Diagnosis of tubuloi-nterstitial nephritis and polyserositis was confirmed with consecutive pulse doses of steroid therapy. After reco-very, she had disseminated disease two months later. Magnetic resonance imaging showed thickened intestine wall, extremely augmented kidneys, enlarged intra-abdominal lymph nodes with extra-luminal compression of common bile duct. Laparotomy with mesenterial adipous tissue and lymph glands biopsy was done. Consecutive pathophysiological and immunohistochemical analyses confirmed the diagnosis of EATCL： CD45RO＋, CD43＋, CD3＋. The revision of renal pathophysiology sub-stantiated the diagnosis. The patient received chemotherapy, but unfortunately she died manifesting signs of pulmonary embolism caused by tumor cells.

关键词： EATCL Acute renal failure Celiac disease anti-endomisial antibodies

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