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anti-diabetic and anti-cholesterolemic activity of methanol extracts of three species of Amaranthus

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Asian Pacific Journal of Tropical Biomedicine 2011年第2期1卷 133-138页

作者： Girija K Lakshman K Udaya Chandrika Sabhya Sachi Ghosh Divya T Department of Pharmacognosy PES College of Pharmacy

Objective:To investigate the anti-diabetic and anti-cholesterolemic activity of methanol extracts of leaves of Amaranthus caudatus,Amaranthus spinosus and Amaranthus viridis in normal and streptozotocin(STZ) induced diabetic ***:In this study,the anti-diabetic and anti-cholesterolemic activity of methanol extracts of leaves of all three plants was evaluated by using normal and STZ induced diabetic rots at a dose of 200 mg/kg and 400 mg/kg *** for 21 *** glucose levels and body weight were monitored at specific intervals,and different biochemical parameters,serum cholesterol,serum triglyceride,high density lipoprotein, low density lipoprotein and very low density lipoprotein were also assessed in the experimental *** of pancreas was ***:It was found that all the three plants at 400 mg/kg dose showed significant anti-diabetic and anti-cholesterolemic activity(Panti-diabetic activity(Panti-diabetic and anti-cholesterolemic activity,which provides the scientific proof for their traditional claims.

关键词： Amaranthus caudatus Amaranthus spinosus Amaranthus viridis anti-diabetic activity anti-cholesterolemic activity Methanol extract Biochemical parameter

anti-diabetic potential of Urena lobata leaf extract through inhibition of dipeptidyl peptidase IV activity

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Asian Pacific Journal of Tropical Biomedicine 2015年第8期5卷 630-634页

作者： Yudi Purnomo Djoko Wahono Soeatmadji Sutiman Bambang Sumitro Mochammad Aris Widodo School of Medicine Brawijaya University Pharmacology Department School of Medicine Malang Islamic University Internal Department School of Medicine Brawijaya University Biology Department Faculty of Science Brawijaya University Pharmacology Department School of Medicine Brawijaya University

Objective: To evaluate the anti-diabetic potential of leaf extract from Urena lobata(U. lobata) through dipeptidyl peptidase IV(DPP-IV) inhibitory ***: U. lobata leaf was extracted in hot water and ethanol. The activity of DPPIV inhibitor was tested by in vitro study using gly-pro-p-nitroanilide as substrat of DPPIV and vildagliptin, as standard reference. A product of the reactions between gly-pro-pnitroanilide and DPP-IV, was observed by microplate readers with λ = 405 nm. All data were expressed as mean ± SD and the IC50 value was determined by non linear regression curve fit. Active substances in leaf extract of U. lobata was analyzed by liquid chromatography-mass spectrometry. DPP-IV inhibitory activity of active compounds was evaluated in silico using docking server. Results: The ethanolic extract of U. lobata showed stronger DPP-IV inhibitor activity than water extract with the IC50 values of 1 654.64 and 6 489.88 μg/mL, respectively. Vildagliptin, based on standard reference for DPP-IV inhibitor activity, has IC50 value of 57.44 μg/mL. Based on in silico analysis, mangiferin, stigmasterol and β-sitosterol in U. lobata extract have a strong inhibitory activity on DPP-IV. Conclusions: The results showed that DPP-IV inhibitory activity of U. lobata is related to its active compounds such as mangiferin, stigmasterol and β-sitosterol.

关键词： anti-diabetic Dipeptidyl peptidase IV In silico In vitro Urena lobata

A review of five traditionally used anti-diabetic plants of Bangladesh and their pharmacological activities

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Asian Pacific Journal of Tropical Medicine 2017年第10期10卷 933-939页

作者： Md.Rajdoula Rafe Department of Pharmacy Southeast UniversityDhakaBangladesh

Plants are used traditionally throughout the globe to treat various *** used medicinal plants are an essential part of the health sector in Bangladesh due to its abundance of a vast source of *** people from developing country like Bangladesh are greatly dependent on traditional source of *** prevalence of diabetes mellitus is increasing from recent years; therefore various researches are going on to discover better medicine to treat this *** study has focused on five plants which are Andrographis paniculata, Ageratum conyzoides, Swertia chirata, Terminalia arjuna, and Azadirachta indica to find out their traditional formulation as anti-diabetic medicine and their pharmacological activity has also been explored through literature *** available information about traditional anti-diabetic uses of these plants and their pharmacological activities were collected from various electronic sources like Pubmed, Sci Finder, Elsevier, Springer, Scopus, Scirus, Science Direct, Google Scholar and Web of Science apart from these locally available books and peer reviewed journal were also used to collect *** study will help to strengthen the relation between traditional medicine, pharmacology and drug development.A clue may be found from the information provided this review to discover new and better anti-diabetic drugs.

关键词： anti-diabetic Traditional Ethno-medicine Pharmacology Bangladesh

A comprehensive review on anti-diabetic property of rice bran

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Asian Pacific Journal of Tropical Biomedicine 2018年第1期8卷 79-84页

作者： Bhagavathi Sundaram Sivamaruthi Periyanaina Kesika Chaiyavat Chaiyasut Innovation Center for Holistic Health Nutraceuticals and Cosmeceuticals Faculty of Pharmacy Chiang Mai University

Rice bran(RB) is one of the nutrient-rich agricultural byproducts. It is a composite of carbohydrates, lipids, proteins, fibers, minerals, and trace elements such as phosphorus, potassium, magnesium, calcium and manganese. The extraction and purification process influences the quality and quantity of rice bran oil, which is rich in tocopherols, tocotrienols, 毭-oryzanol, and unsaturated fatty acids. The bioactive components of RB have been reported for exhibiting antioxidant, anti-inflammatory, hypocholesterolemic, anti-cancer, anti-colitis, and antidiabetic properties. In vitro and in vivo studies, and clinical trials in human volunteers revealed the anti-hyperglycemic activity of RB derived compounds. An updated comprehensive review on the antidiabetic property of RB and its derivative is required to appraise the current knowledge in the particular field. Thus, the present paper covered the composition and bioactivities of RB, and influence of extraction methods on the biological property of rice bran oil and rice bran extract. And the current review also focused on the reported antihyperglycemia activity of rice bran derivatives, and its probable mechanism.

关键词： anti-diabetic Anthocyanins Rice bran Rice bran oil Rice bran extract γ-oryzanol

<i>In Vitro</i>anti-diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in <i>Meriandra dianthera, Aloe camperi</i>and a Polyherb

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American Journal of Plant Sciences 2017年第3期8卷 533-548页

作者： Mussie Sium Patrick Kareru Beatrice Kiage-Mokua Kaushal Sood John Langley Julie Herniman Department of Chemistry College of Science Eritrea Institute of Technology Asmara Eritrea Department of Chemistry Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Department of Food Science and Technology Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Centre for Studies in Biotechnology Dibrugarh University Dibrugarh India Department of Chemistry University of Southampton Southampton UK

This paper reports the in vitro anti-diabetic profile of certain medicinal plants traditionally used in Eritrea for the management of type 2 diabetes. The crude methanolic extracts and fractions of Meriandra dianthera, Aloe camperi, a Polyherb and their fractions were investigated. The in vitro screening of the crude extracts has generally elicited a dose dependent α-glucosidase and α-amylase inhibition activities. M. dianthera displayed the highest α-glucosidase inhibitory activity (IC50: 0.074 ± 0.032 mg/mL) at the highest concentration tested (0.800 mg/mL) relative to A. camperi, the Polyherb and Acarbose (IC50: 0.37 ± 0.052, 0.56 ± 0.024 and 0.55 ± 0.029 respectively). The α-glucosidase inhibition activities of A. camperi and M. dianthera, except for the Polyherb and Acarbose, were significantly different (P anti-diabetic screening of the fractions, at 0.800 mg/ml, displayed characteristic enzyme inhibition activities. Generally, the non-polar fractions showed higher enzyme inhibitory activities compared to the polar fractions. The most bioactive non-polar fractions, thus, were subjected to GC-MS analysis and presented various essential oils, fatty acid methyl esters (FAMEs) and benzoic acid derivatives in those plants.

关键词： anti-diabetic α-Glucosidase α-Amylase GC-MS Essential Oils Fatty Acid Methyl Esters

anti-diabetic effects of cold and hot extracted virgin coconut oil

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Journal of Diabetes Mellitus 2011年第4期1卷 118-123页

作者： Mahadevappa Siddalingaswamy Arunchand Rayaorth Farhath Khanum 不详

Virgin coconut oil (VCO) has been shown to possess insulinotropic effects shown in isolated perfused mouse islet with hypolipidemic effects. Hot extracted virgin coconut oil (HEVCO) has been shown to possess better antioxidant properties than cold extracted virgin coconut oil (CEVCO). These properties were exploited to study the anti-diabetic effects of HEVCO and CEVCO in diabetic rats. Four groups 8 rats each, first group served as non-diabetic control remaining groups were made diabetic and force fed with 2ml alcoholic extracts of commercial coconut oil (CCO), CEVCO and HEVCO for 21 days. Blood glucose once in 5 days, body weight gain, food intake once in a week and water intake and urine output daily, were monitored. Animals were sacrificed at the end of 21 days. The results indicated HEVCO reduced blood glucose and lipids viz total cholesterol (TC), triglycerides (TG), High density lipoproteins (HDL), Low and Very Low Density Lipoprotein (LDL+ VLDL) and thiobarbutyric acid reactive substances (TBARS) increased the antioxidant status by elevating activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px), glutathione (GSH) concentration and decresed lipid peroxidation in liver than CEVCO. These beneficial effects may be attributed to increased polyphenolic and other antioxidants content present in HEVCO.

关键词： anti-diabetic HEVCO CEVCO CCO Hypoglycemic Hypolipidemic antioxidant Enzymes

Microbial Transformation of the anti-diabetic Agent Corosolic Acid

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Microbial Transformation of the Anti-diabetic Agent Corosoli...

Vanadyl complexes loading on Graphene quantum dots(GQDs) improved anti-diabetic effect

全国第九届海洋生物技术与创新药物学术会议

作者： Xu Feng Dai-ping Li Jie Luan Zhi-yong Chu Navy Medical Research Institute

Biotransformation of corosolic acid(1)by Cochliobolus lunatus and Streptomyces asparaginoviolaceus afforded four metabolites,which were identified by 1H NMR,13C NMR,DEPT,HSQC,HMBC and NOESY spectral *** of corosolic acid by *** ***&Haasis CGMCC 3.4381 produced three metabolites:2a,3p,210-trihydroxyurs-12-en-28-oic acid(2),2a,3p,7β,21β-tetrahydroxy-urs-12-en-28-oic acid(3)and2α,3β-dihydroxy-21-oxours-12-en-28-oic acid(4).Incubation of corosolic acid with growing cultures of *** CGMCC 4.0175 afforded metabolite 2a,3p\30-trihydroxyurs-12-en-28-oic acid(5).All of the metabolites were reported for the first *** substrate and four metabolites,along with 4 products obtained previously,were evaluated for their inhibitory effects on a-glucosidase,all of the triterpenes tested showed potent inhibitory effects.

关键词： Triterpenoid Biotransformation Corosolic acid anti-diabetic Cochliobolus lunatus Streptomyces asparaginoviolaceus

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Vasorelaxant effects of biochemical constituents of various medicinal plants and their benefits in diab

第十一届全国化学生物学学术会议

作者： Du Jiaojiao Yang Xiaoda The State Key Laboratories of Natural and Biomimetic Drugs School of Pharmaceutical SciencePeking University SATCM Key Laboratory of Compound Drug Detoxication Peking University

Vanadium complexes are promising anti-diabetic *** key issue of rational drug design of anti-diabetic vanadium complexes will still be how to balance the potential toxicity and pharmacological activities. Previously,we have successfully obtained vanadium complexes with reduced toxicity by incorporation of antioxidant ligands. Herein,based on graphene quantum dot(GQD) platform,we designed and synthesized novel GQD-VOL vanadium complexes,in which vanadyl complexes were loaded on *** structures and properties of GQD-VOL have been *** results indicated that vanadium complexes were assembled on GQDs by non-covalent *** apparent permeability coefficient of GQD-VOL on Madin Darby Canine Kidney cell monolayer was significantly *** type Ⅱ diabetic mice model,GQD-VOL exhibited more stable hypoglycemic *** the fasting state,GQD-VOL-treated mice gradually decreased their blood glucose into the normal ***,the experimental results indicated that GQD-VOL can be a potent anti-diabetic agent for further drug development.

关键词： Vanadyl complexes graphene quantum dots anti-diabetic

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World Journal of Diabetes 2024年第6期15卷 1122-1141页

作者： Sadettin Demirel Medicine School Physiology DepartmentBursa Uludag UniversityBursa 16059Türkiye

Endothelial function plays a pivotal role in cardiovascular health,and dysfunction in this context diminishes vasorelaxation concomitant with endothelial *** nitric oxide-cyclic guanosine monophosphate pathway,prostacyclin-cyclic adenosine monophosphate pathway,inhibition of phosphodiesterase,and the opening of potassium channels,coupled with the reduction of calcium levels in the cell,constitute critical mechanisms governing *** disease stands as a significant contributor to morbidity and mortality among individuals with diabetes,with adults afflicted by diabetes exhibiting a heightened cardiovascular risk compared to their non-diabetic counterparts.A plethora of medicinal plants,characterized by potent pharmacological effects and minimal side effects,holds promise in addressing these *** this review,we delineate various medicinal plants and their respective biochemical constituents,showcasing concurrent vasorelaxant and anti-diabetic activities.

关键词： Medicinal plants Vasorelaxation Endothelium Diabetes anti-diabetic