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anti-glial fibrillary acidic protein antibody and anti-aquaporin-4 antibody double-positive neuromyelitis optica spectrum disorder:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8192-8199页

作者： Ting-Yu Jin Bing-Tong Lin Li-Jv Dai Xia Lu Han Gao Jin Hu Department of Neurology First Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND A case of neuromyelitis optica spectrum disorder(NMOSD)with positive cerebrospinal fluid(CSF)anti-aquaporin-4 antibody(AQP4-IgG)and anti-glial fibrillary acidic protein IgG(GFAP-IgG)at the time of relapse was *** exact roles of GFAP-IgG in NMOSD are not fully understood and are the subject of ongoing *** study revealed the possible connection between GFAPIgG and the occurrence or development of *** SUMMARY A 19-year-old woman was admitted to the hospital due to a constellation of symptoms,including dizziness,nausea,and vomiting that commenced 1 year prior,reoccurred 2 mo ago,and were accompanied by visual blurring that also began 2 mo ***,she presented with slurred speech and ptosis,both of which emerged 1 mo ***,her symptoms deteriorated 10 d prior to admission,leading to the onset of arm and leg *** hospitalization,magnetic resonance imaging showed high T2-fluid attenuated inversion recovery signals,and slightly high and equal diffusion-weighted imaging *** serum antibody of AQP4-IgG tested positive at a dilution of 1:*** antibody testing showed positive results for GFAP-IgG at a dilution of 1:10 and AQP4-IgG at a dilution of 1:*** on these findings,the patient was diagnosed with *** received intravenous methylprednisolone at a daily dose of 500 mg for 5 d,followed by a tapering-off ***,the rate of reduction was gradually slowed down and the timely use of immunosuppressants was *** The CFS was slightly GFAP-IgG-positive during the relapse period,which can aid in the diagnosis and treatment of the disease.

关键词： anti-glial fibrillary acidic protein antibody Neuromyelitis optica spectrum disorder anti-aquaporin-4 antibody Cerebrospinal fluid Case report

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Neuromyelitis Optica Spectrum Disorder Associated with Cervical Spondylosis

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Chinese Medical Journal 2015年第22期128卷 3112-3113页

作者： Yuan Zhou Lin Zhu Hui-Lin Cheng Yi-Xing Lin Department of Neurosurgery Jinling Hospital School of Medicine Nanjing University Nanjing Jiangsu 210002 China

Neuromyelitis optica spectrum disease （NMOSD） refers to a group of related disease, in which potential pathogenesis is similar to neuromyelitis optica （NMO）, but clinical involvement does not exactly correspond to the diagnosis of NMO. Owing to varied clinical manifestations, it is apt to be misdiagnosed. We report a case of NMOSD with cervical spondylosis and discuss the experience of diagnosis.

关键词： anti-aquaporin-4 antibody Cervical Spondylosis Magnetic Resonance Imaging Neuromyelitis Optica Spectrum Disorder

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