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Inhibitory effect of humanized anti-vegfr-2 ScFv-As_2O_3-stealth nanoparticles conjugate on growth of human hepatocellular carcinoma:in vitro and in vivo studies

引用

Asian Pacific Journal of Tropical Medicine 2014年第5期7卷 337-343页

作者： Xiang-Bao Yin Lin-Quan Wu Hua-Qun Fu Ming-Wen Huang Kai Wang Fan Zhou Xin Yu Kai-Yang Wang Department of Hepatobiliary Surgery 2nd Affiliated Hospital of Nanchang University

Objective:To investigate the inhibitory effect of humanized anti-vegfr-2 ScFv-As2O3-stealth nanoparticles conjugate on growth of human hepatocellular carcinoma both in vitro and in vivo,which may be a potential agents with sensitivity and targeting ability for human hepatocellular ***:Humanized anli-VECFR-2 ScFv-As2O3-stealth nanoparticles conjugate was previously constructed using ribosome display technology and antibody conjugate *** this combined in vitro and in vivo study,the inhibitory effects of anti-vegfr-2 ScFv-As2O3-stealth nanoparticles conjugate on tumor growth,invasion,and metastasis was observed with human liver carcinoma cell line Bel7402 and normal cell L02 by MTT assay,Tanswell assay,Hochest33258 staining,and DNA ladder *** anticancer activity and distribution of anti-vegfr-2 ScFv-As2O3-stealth nanoparticles was then verified in a mouse model of ***:anti-vegfr-2 ScFv-As2O3-stealth nanoparticles significantly inhibited the proliferation of Bel7402 in the 3-(4,5-dimethylthiazol-2-yh-2,5-diphenyltetrazolium bromide assay while had almost no effects on L02 *** the apoptosis inducing effects were proved by Hochest33258 staining and DNA ladder *** assay found that the drug also inhibited the metastasis ability of tumor ***,anti-vegfr-2 ScFv-As^-stealth nanoparticles significantly delayed the growth of Bel7402 xenografts after administration（92.9%）,followed by As2O3-stealth nanoparticles,anti-vegfr-2 ScFv,and As203（61.4%,58.8%,20.5%,P2O3 in anti-vegfr-2 ScFv-As2O3-steallh nanoparticles group was more ***:anti-vegfr-2 ScFv-As2O3-stealth nanoparticles is a potent and selective anti-hepatocellular carcinoma agent which could inhibit the growth of liver cancer as a targeting agent both in vitro and in vivo and also significantly inhibit angiogenesis.

关键词： anti-vegfr-2 single-chain antibody conjugate As_2O_3 stealth nanoparticles Hepatocellular carcinoma

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