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Evaluation of directly observed treatment short courses at a secondary health institution in Ibadan,Oyo State,Southwestern Nigeria

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Asian Pacific Journal of Tropical Medicine 2013年第12期6卷 952-959页

作者： Olajire A.Adegoke Olalekan A.Orokotan Department of Pharmaceutical Chemistry Faculty of PharmacyUniversity of IbadanIbadanNigeria Department of Clinical Pharmacy and Pharmacy Administration Faculty of PharmacyUniversity of IbadanIbadanNigeria

Objective:To evaluate the success rate of tuberculosis intervention programme at a specialist hospital in(?)badan,Nigeria through a retrospective study as well as carry out physicochemical evaluation of anti-tuberculous agents as a way of eliminating drug-related ***:The retrospective study involved the use of quarterly tuberculosis central register at the Government Chest Hospital,(?)badan between 1st quarter(2003)to 4th quarter(2009).Relevant data were extracted from these register with the aid of data collection *** basic physicochemical analyses of the drugs given to the patients were also carried out using the International Pharmacopoeia ***:All the drugs examined for their physicochemical properties passed the International Pharmacopeia recommended tests.A total number of 1 260 patients enrolled at the hospital were assessed through case *** comprises of 59.4%males of which69.23%new cases were also *** was a significant(P0.05).Failure rates in all categories were higher in males than females(P>0.05).Conclusions:More enlightenment and counseling is still required to meet up with the target for tb control.

关键词： Tuberculosis DOTS therapy Success rate anti-tb drugs Physicochemical evaluation

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Prevalence and Risk Factors of Adverse Drug Reactions Associated Multidrug Resistant Tuberculosis Treatments in Selected Treatment Centers in Addis Ababa Ethiopia

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Journal of Tuberculosis Research 2014年第3期2卷 144-154页

作者： Haregewoin Bezu Daniel Seifu Getnet Yimer Tesfamariam Mebrhatu All Africa Leprosy TB Rehabilitation and Training Center Armauer Hansen Research Institute (AHRI/ALERT) Addis Ababa Ethiopia Department of Medical Biochemistry College of Health Sciences Addis Ababa University Addis Ababa Ethiopia Research and Technology Transfer College of Health Sciences Addis Ababa University Addis Ababa Ethiopia

Introduction: The key to successful elimination of tuberculosis (tb) is treatment of cases with optimum chemotherapy. Irrational anti-tb drug use over time has led to drug-resistant tb. The treatment of MDR-tb with second line drugs is long, complex and costly, and has a considerable rate of adverse effects. The level of ADR reporting is low in Ethiopia due to different factors. This Study conducted in a selected treated area in Addis Ababa, Ethiopia and helped the health care centers to understand the prevalence of ADR related MDR-tb and be aware of those adverse effects in order to detect them early and be prepared to take proper steps when they occur. Aim of the Study: To determine the prevalence and risk factor of adverse drug reactions associated treatments of Multidrug Resistant tuberculosis. Method: This was a cross sectional study, which was conducted between March 2012 and February 2013 at St. Peter tb specialized hospital and AHRI/ALERT. 73 MDR tb patients, who were on MDR tb treatments, enrolled to the study. Adverse Drug Reactions associated MDR tb treatments were assessed by patient history review and questionnaire. Chemistry laboratory was used to test renal function, thyroid function, liver enzyme and potassium level. Result: In 72 patients, at least two ADRs were found. The mean age of the study population (Mean ± SD) was 28 ± 8.8. In this study the most commonly found adverse drug reactions (ADRs) were: Anorexia 83.3%, Nausea and vomiting 82%, Gastritis 64%, Arteralgia 47%, Skin rash and itching 45%, Headache 29.2%, Depression 22.2% and Blurred vision 19.4%. Using binary logistic regression model older age (COR 8.71, 95% [CI] 1.06 - 71.9), alcoholism (COR 4.05, 95% [CI] 1.05 - 15.6), smoking (COR 0.24, 95% [CI] 0.06 - 0.87) and concomitant drug intake (COR 0.14, 95% [CI] 0.03 - 0.76) were independent predictors for ADRs. Conclusion: The prevalence of ADRs related MDR tb treatments is high. To minimize ADR occurrence, ADR predictors should be integra

关键词： MDR tb ADR Second Line anti-tb Treatment

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Tuberculosis of the Spine (L5, S1) Secondary to Scrofuloderma with Viral Warts in a 15-Year-Old Male

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Case Reports in Clinical Medicine 2018年第1期7卷 70-83页

作者： Akunnaya Chioma Ohanenye Nneka Chioma Okoronkwo Department of Paediatrics Abia State University Teaching Hospital Aba Nigeria

We report this case of a 15-year-old male who presented to the children outpatient clinic (CHOP) of Abia State University Teaching Hospital (ABSUTH), Aba on the 5th of November 2015. He had tuberculosis (tb) of the skin (scrofuloderma) which was not diagnosed and had received treatment other than anti-tb medication. He now presented 9 years after with multiple body discharging sinuses, cicatricial skin lesions, tuberculosis of the spine (L5, S1) with contracture of the Achilles Tendon and genital warts. Subsequent treatment with full anti-tb drugs led to resolution of his illness. A higher index of suspicion is required for early diagnosis of extrapulmonary tb. Prompt and adequate treatment with anti-tb medication ensures cure in such cases. Appropriate control program is also known to improve the outcome and reduce sequelae.

关键词： Tuberculosis Spine Scrofuloderma Viral Warts anti-tb Drugs ABSUTH

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