检索结果-南通市图书馆

Profiles of HIV-infected anti-retroviral therapy naïve children from Mumbai,India

世界儿科杂志:英文版 2016年第4期12卷 430-435页

作者： Supriya Mayur Paranjpe Purva Pankaj Sarkate Nayana Avinash Ingole Shweta Sadanand Raut Preeti Rajeev Mehta Department of Microbiology 5th floorMulti-Storey BuildingSeth G.S.Medical College and K.E.M.HospitalParelMumbaiIndia

Background:This study aimed to investigate the demographic profiles of human immunodifficiency virus(HIV)infected anti-retroviral therapy(ART)naïve children in our hospital and their relations to the clinical,immunological and nutritional ***:A cross-sectional study was conducted in an Integrated Counselling and Testing Center(ICTC)at a tertiary care hospital in *** naïve HIV positive children were enrolled in the *** demographic profiles,clinical features,immunological(CD4%/CD4 count)and nutritional status of these children were *** agreement between clinical,immunological and nutritional staging was determined using Cohen’s kappa ***:In 192 HIV-infected ART naive children enrolled with a median age of 9 years(range 3 months-14 years),97.4%acquired infection through vertical *** most common clinical presentation was fever(39.6%),followed by generalized lymphadenopathy(32.3%),cough(22.4%)and diarrhoea(9.9%).Tuberculosis was seen in 22.9%of the *** agreement was fair between clinical and immunological staging,and slight between nutritional,immunological and clinical ***:Perinatal transmission is the most common mode of acquiring HIV infection in *** Prevention of Parent to Child Transmission(PPTCT)program should be strengthened for lowering the transmission rate by providing extended ART to mothers during pregnancy and *** remains a major concern in HIV-infected *** poor correlation between WHO clinical and immunological staging emphasizes the importance of making CD4 facilities available in HIV prevalent *** cannot be used as a surrogate marker for predicting stage or severity as it is common at all stages of HIV disease.

关键词： anti-retroviral therapy CD4 count clinical stage HIV nutritional status

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Risk Factors for Viral Non-Suppression among People Living with HIV and Major Depressive Disorder in Uganda

引用

World Journal of AIDS 2022年第2期12卷 43-54页

作者： Lilian Bulage Benedict Akimana Justine D. Namuli Seggane Musisi Josephine Birungi Micheal Etukoit Ramin Mojtabai Jean B. Nachega Edward J. Mills Etheldreda Nakimuli-Mpungu African Field Epidemiology Network Kampala Uganda Uganda Public Health Fellowship Program Kampala Uganda Ministry of Health Butabika National Referral Mental Hospital Kampala Uganda Department of Psychiatry College of Health Sciences Makerere University Kampala Uganda The AIDS Support Organization (TASO) Kampala Uganda Department of Mental Health Bloomberg’s School of Public Health Johns Hopkins University Baltimore USA Departments of Epidemiology Infectious Diseases and Microbiology Graduate School of Public Health University of Pittsburgh Pittsburgh USA Center for Infectious Disease Department of Medicine Faculty of Medicine and Health Sciences Stellenbosch University Cape Town South Africa Departments of International Health and Epidemiology Bloomberg’s School of Public Health Johns Hopkins University Baltimore USA Department of Clinical Epidemiology & Biostatistics McMaster University Hamilton Canada

Background: Several studies indicate that depression is associated with non-viral suppression among persons living with HIV (PLWH) using antiretroviral therapy (ART) worldwide. However, among PLWH with major depressive disorder, factors associated with non-viral suppression remain uncertain. We determined the prevalence and identified the factors associated with viral non-suppression among PLWH with major depressive disorder using ART in Northern Uganda. Method: A total of 30 primary care HIV clinics across three northern districts (Gulu, Kitgum, Pader) participated in the study. Using baseline data from the SEEK-GSP study, a cluster-randomized trial in northern Uganda (2016-2019) that involved 1140 PLWH with mild to moderate major depressive disorder;we examined the demographic, clinical, and psychosocial factors using standardized questionnaires. Data on viral load was abstracted from clinic records and dichotomized into suppressed (Results: We recruited 1140 PLWH. The viral non-suppression prevalence was 12.2%. In multivariable analysis, the only baseline psychosocial variable independently associated with non-viral suppression was suicide risk (PRR = 1.56, 95% CI: 1.05 - 2.32, p-value = 0.029). The prevalence odds for non-viral suppression were 56% higher among depressed PLWH with moderate to high suicide risk than those with low suicide risk. Among clinical variables, duration on ART ≥ 4 years was independently associated with non-viral suppression (PRR = 1.62, 95% CI: 1.09 - 2.32, p-value = 0.015). Conclusions: Suicide risk and longer duration on ART are associated with non-viral suppression among anti-retroviral therapy users with mild to moderate major depressive disorder in Uganda. As ART is scaled up across Sub-Saharan Africa, first-line psychological care for depression and its complications is urgently needed in established HIV treatment centers.

关键词： Depression Suicide Risk anti-retroviral therapy Viral Suppression Uganda

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Successful Treatment with Triple therapy of Amphotericin B, Voriconazole and Flucytosine on an AIDS Patients with Severe Cryptococcal Meningitis

引用

国际感染病学（电子版） 2012年第2期1卷 110-113页

作者： Zhi-liang Hu Hong-xia Wei Wen-hu Yao Yong-feng Yang Department of Infectious Diseases the Second Affiliated Hospital of the Southeast University

A 35-year-old man(body weight=63 kg)with AIDS complaining fever and headache after having commenced anti-retroviral therapy(ART)for a week was admitted to our *** lumbar punctures performed during38 days could not confirm a cryptococcal meningitis(CM)based on staining or culture methods for cerebrospinal fluid(CSF).The disease quickly progressed with serious hearing/vision impairment and frequent onset of seizure and coma after being treated with corticosteroids for five days,and then CM was *** lumbar puncture showed elevated intracranial pressure as high as 870 mm H2O,even though treated with standard antifungal regimens for *** disease was finally controlled by a new triple therapy with amphotericin B(0.7mg?kg-1?day-1,intravenously),flucytosine(100 mg/kg perday,orally in four divided doses),and voriconazole(200mg every 12 hours)and ART containing lamivudine(300 mg/day),stavuding(30 mg,twice a day)and efavirenz(300 mg,orally every night).Although it is rare,negative CSF stain or culture for cryptococci in AIDS patients with CM can persist for a long *** should be used cautiously when an effective anti-fungal therapy is not *** therapy with amphotericin B,flucytosine and voriconazole may be selectively applied in severe *** can be co-administered with efavirenz with modified dosing.

关键词： Cryptococcal meningitis anti-retroviral therapy Corticosteroids Voriconazole Efavirenz

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：