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anti-lymphocyte antibody-based immunotherapy in type 1 diabetes

Chinese Medical Journal 2013年第5期126卷 957-964页

作者： XIA Chang-qing LIU Yuan-tao GUAN Qing-bo Michael Clare-Salzler Department of Hematology Xuanwu Hospital Capital MedicalUniversity Beijing 100053 China Department of Endocrinology Second Hospital of ShandongUniversity Jinan Shandong 250033 China Department of Endocrinology Provincial Hospital Affiliated toShandong University Jinan Shandong 250030 China Diabetes Center at Department of Pathology Immunology andLaboratory Medicine University of Florida Gainesville FL32610 USA

Type 1 diabetes （T1D） is an insulin-dependent diabetes because of insufficient insulin production by the pancreatic islet 15 cells. Although the patnogemc mechanism of T1D is not yet completely clear, the current view of T1D pathogenesis is that under certain genetic background, exogenous or endogenous factors trigger autoimmunity against islet β cells in the pancreas causing β cell damage and subsequent insufficiency of insulin production. About two decades ago, it was first demonstrated that T cells specific ~o 15 cell antigens were activated and participated in the pathogenesis of T I D.3＇4 A great deal of work following these reports in both animal models and humans has provided convincing data further supporting T1D is a T cell-mediated autoimmune disease.

关键词： type 1 diabetes immunotherapy anti-cd3 antibody anti-cd20 antibody anti-thymocyte globulin

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Hepatitis B Reactivation with Novel Agents in Non-Hodgkin's Lymphoma and Prevention Strategies

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Journal of Clinical and Translational Hepatology 2016年第2期4卷 143-150页

作者： Oluwatobi O.Ozoya Lubomir Sokol Samir Dalia Emergency and Trauma Center Tampa General HospitalTampaFLUSA Department of Hematological Malignancies H.Lee Moffitt Cancer CenterTampaFLUSA Oncology and Hematology Mercy Clinic JoplinJoplinMOUSA

Hepatitis B virus (HBV) infection remains an endemic disease in most parts of the world despite available prophylactic ***-Hodgkin's lymphoma is the most common hematological malignancy,and certain patients undergoing therapy are at increased risk of HBV ***,a monoclonal antibody,is well studied in HBV reactivation,but newer agents have been implicated as ***,we review novel agents suspected in HBV reactivation and effective strategies to prevent HBV *** years of literature were reviewed in order to better understand the reactivation rates of hepatitis B in patients with non-Hodgkin's ***-cd20 antibodies continue to be the main medications that can lead to HBV reactivation,and HBV reactivation rates have decreased with increased *** reactivation is uncommon when using other novel *** and lamivudine remain the agents of choice to prevent HBV reactivation in high risk *** conclusion,the immunosuppressive effect of NHL and its therapy provide a pathway for HBV reactivation,especially in patients treated with anti-cd20 *** many HBV positive patients are often excluded from clinical trials of novel agents in NHL,more aggressive post-market surveillance of new agents,welldesigned best practice advisories,and timely case reports are needed to reduce the incidence of HBV ***,large prospective investigations coupled with well-utilized best practice advisories need to be conducted to understand the impact of more potent novel NHL therapy on HBV reactivation.(C) 2016 The Second Affiliated Hospital of Chongqing Medical *** by XIA & HE Publishing *** rights reserved.

关键词： Hepatitis B virus HBV reactivation Non-Hodgkin's lymphoma Rituximab anti-cd20 antibody Best practice advisories

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