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antioxidative potential of a combined therapy of anti TNFα and Zn acetate in experimental colitis

World Journal of Gastroenterology 2011年第36期17卷 4099-4103页

作者： Michela Barollo Valentina Medici Renata DIncà Antara Banerjee Giuseppe Ingravallo Marco Scarpa Surajit Patak Cesare Ruffolo Romilda Cardin Giacomo Carlo Sturniolo Department of Surgical and Gastroenterological Sciences University of PadovaPadova 35128Italy Department of Internal Medicine Division of Gastroenterology and HepatologyUniversity of CaliforniaDavisCA 95616United States Department of Pathology University of BariBari 70121Italy Department of Oncological Surgery Veneto Oncological InstitutePadova 35128Italy

AIM:To evaluate whether combination therapy with antitumour necrosis factor α (TNFα) antibody and Zn acetate is beneficial in dextran sodium sulphate (DSS) ***:Colitis was induced in CD1-Swiss mice with 5% DSS for 7 *** experimental mice were then randomised into the following subgroups:standard diet + DSS treated (induced colitis group);standard diet + DSS + subcutaneous 25 μg anti-TNFα treated group;Zn acetate treated group + DSS + subcutaneous 25 μg anti-TNFα;standard diet + DSS + subcutaneous 6.25 μg anti-TNFα treated group and Zn acetate treated group + DSS + subcutaneous 6.25 μg anti-TNFα.Each group of mice was matched with a similar group of sham control *** and histological features were scored *** of the colonic mucosa were assessed for myeloperoxidase activity as a biochemical marker of inflammation and DNA adducts (8OH-dG) as a measure of oxidative ***:DSS produced submucosal erosions,ulcers,inflammatory cell infiltration and cryptic abscesses which were reduced in both groups of mice receiving either anti-TNFα alone or combined with *** effect was more pronounced in the latter group (vs Zn diet,P anti-TNFα.Combining anti-TNFα with Zn acetate offers marginal benefit in colitis severity.

关键词： anti tumor necrosis factor α Experimental colitis Inflammatory bowel disease Oxidative damage Zinc

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