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Neuroinflammation and excitatory symptoms in bipolar disorder

Neuroimmunology and Neuroinflammation 2015年第1期2卷 215-227页

作者： Isabella Panaccione Gianfranco Spalletta Gabriele Sani Department of Neuroscience Mental Health and Sensory OrgansSchool of Medicine and PsychologySapienza University of RomeSant’Andrea Hospital00189 RomeItaly Department of Clinical and Behavioural Neurology Neuropsychiatry LaboratoryIRCCS Santa Lucia Foundation00179 RomeItaly Centro Lucio Bini 00193 RomeItaly Menninger Department of Psychiatry and Behavioral Sciences Beth K and Stuart C Yudofsky Division of NeuropsychiatryBaylor College of MedicineHoustonTX 77030USA

Neuroinflammation has been proposed as a strong biological factor underlying the development of neuropsychiatric diseases.A role for dysregulation of the immune system was initially suggested in depressive disorders and subsequently extended to other illnesses,including bipolar disorder(BD).Indeed,there is growing evidence confirming the presence of a generalized pro-inflammatory state in BD patients,involving alterations in cytokine,acute-phase proteins,and complement factor secretion,white blood cell differentiation,microglial activation,arachidonic acid signaling pathways,and increased oxidative stress *** commonly used to treat BD,such as lithium,antiepileptics and antipsychotics,show some immunoregulatory activity both in vitro and in *** aim of our study was to review the role of different inflammatory mechanisms,specifically in the development of excitatory symptoms,via a systematic PubMed search of the *** the high variability of results among studies,we found evidence indicating specific alterations of the inflammatory response during manic and mixed states of *** findings may help to clarify some of the complex mechanisms underlying the development of excitatory symptoms and suggest a potential role for drugs targeting the inflammatory system as new therapeutic options.

关键词： anti‑inflammatory drugs bipolar disorder glia interleukin mania mixed states neuroinflammation

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