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Spectrum of delayed post-hypoxic leukoencephalopathy syndrome:A systematic review

World Journal of Clinical Cases 2024年第29期12卷 6285-6301页

作者： Bahadar S Srichawla Maria A Garcia-Dominguez Department of Neurology University of Massachusetts Chan Medical SchoolWorcesterMA 01655United States

BACKGROUND Delayed post hypoxic leukoencephalopathy syndrome(DPHLS),also known as Grinker’s myelinopathy,is a rare but significant neurological condition that manifests days to weeks after a hypoxic *** by delayed onset of neurological and cognitive deficits,DPHLS presents substantial diagnostic and therapeutic *** To consolidate current knowledge on pathophysiology,clinical features,diagnostic approaches,and management strategies for DPHLS,providing a comprehensive overview and highlighting gaps for future *** Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes guidelines,we systematically searched PubMed,ScienceDirect and Hinari databases using terms related to delayed post-hypoxic *** criteria were original research articles,case reports,and case series involving human subjects with detailed clinical,neuroimaging,or pathological data on *** were extracted on study characteristics,participant demographics,clinical features,neuroimaging findings,pathological findings,treatment,and *** quality assessment was performed using the Joanna Briggs Institute critical appraisal *** A total of 73 cases were *** comorbidities included schizoaffective disorder,bipolar disorder,hypertension,and substance use *** primary causes of hypoxia were benzodiazepine overdose,opioid overdose,polysubstance overdose,and carbon monoxide(CO)*** frequently include decreased level of consciousness,psychomotor agitation,cognitive decline,parkinsonism,and *** commonly revealed diffuse T2 hyperintensities in cerebral white matter,sometimes involving the basal ganglia and the globus *** resonance spectroscopy often showed decreased N-acetylaspartate,elevated choline,choline-to-creatinine ratio,and normal or elevated *** is often supportive,including amantadine,an antioxidant cocktail,and

关键词： Delayed post hypoxic leukoencephalopathy syndrome anoxic encephalopathy Delayed post hypoxic leukoencephalopathy Hypoxic-ischemic brain injury Grinker's myelinopathy Toxic leukoencephalopathy Toxic leukoencephalopathy Delayed postanoxic encephalopathy Carbon monoxide poisoning

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