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annona muricata:Is the natural therapy to most disease conditions including cancer growing in our backyard?A systematic review of its research history and future prospects

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 835-848页

作者： Yahaya Gavamukulya Fred Wamunyokoli Hany A.El-Shemy Department of Molecular Biology and Biotechnology Pan African University Institute for Basic SciencesTechnology and Innovation(PAUSTI)P.O.Box62000-00200 NairobiKenya Department of Biochemistry and Molecular Biology Busitema University Faculty of Health SciencesP.O.Box1460 MbaleUganda Department of Biochemistry Jomo Kenyatta University of Agriculture and TechnologyP.O.Box62000-00200 NairobiKenya Department of Biochemistry Faculty of AgricultureCairo University12613 GizaEgypt

annona muricata(***)is a tropical plant species belonging to family annonaceae and known for its many medicinal *** review focuses on the research history of its traditional uses,phytochemicals,pharmacological activities,toxicological aspects of the extracts and isolated compounds,as well as the in vitro propagation studies with the objective of stimulating further studies on this plant for human consumption and *** extracts have been identified in tropical regions to traditionally treat diverse conditions ranging from fever to diabetes and *** than 200 chemical compounds have been identified and isolated from this plant,the most important being alkaloids,phenols and *** in vitro studies,its extracts and phytochemicals have been characterized as antioxidant,anti-microbial,anti-inflammatory,insecticidal,larvicidal,and cytotoxic to cancer *** vivo studies have revealed anxiolytic,antistress,anti-inflammatory,immunomodulatory,antimalarial,antidepressant,gastro protective,wound healing,hepato-protective,hypoglycemic,anticancer and anti-tumoral *** silico studies have also been *** addition,clinical studies support the hypoglycemic as well as some anticancer *** of action of some pharmacological activities have been ***,some phytochemical compounds isolated from *** have shown a neurotoxic effect in vitro and in vivo,and therefore,these crude extracts and isolated compounds need to be further investigated to define the magnitude of the effects,optimal dosage,and mechanisms of action,long-term safety,and potential side ***,more clinical studies are necessary to support the therapeutic potential of this *** studies were also found to have successfully regenerated the plant in vitro,but with limited *** reported toxicity notwithstanding,*** extracts seem to be some of the safest and promising therapeutic agents of the 21st

关键词： annona muricata Traditional medicinal uses Phytochemicals Acetogenins Bioactivity Cytotoxicity

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Muricatenol, a Linear Acetogenin from annona muricata (annonaceae)

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Chinese Chemical Letters 2000年第3期11卷 239-242页

作者： De Yu LI Jing Guang YU Xiu Zhen LUO Lan SUN Shi Lin YANG (Institute of Medicinal Plant Development. Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing 100094) Inst. of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100094 China

Muricatenol 1, a new acetogenin, has been isolated from the seeds of annona muricata L.. Compound 1 is a C-37 acetogenin without any THF rings. with four hydroxyls and one double bond in the long aliphatic chain. The hydroxyls of 1 are located at C-4, C-10, C-18 and C-19. respectively. The vicinal diet at C-18/C-19 is threo-configuration, and the double bond at C-14/C-15 is cis-configuration.

关键词： annona muricata annonaceae acetogenins muricatenol

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Palm Red Mite Management with Soursop Seed Plant Residue Extracts

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Agricultural Sciences 2023年第4期14卷 541-552页

作者： Ana Beatriz Mamedes Piffer Evellyn Zuqui Bolsoni Isabella Merlo Fornaciari Anderson Mathias Holtz Johnatan Jair De Paula Marchiori Jose Romário De Carvalho Ronilda Lana Aguiar Patrícia Soares Furno Fontes Bruna De Oliveira Magnani Campus Itapina Federal Institute of Espírito Santo Colatina Brazil Campus Seropédica Federal University Rural of Rio de Janeiro Seropédica Brazil Secretary of State for Education of Espírito Santo Gua&#231uí Brazil

Raoiella indica Hirst, 1924 (Prostigmata: Tenuipalpidae), is one of the leading pest mites in palm and banana trees, however, there are few control methods available for this pest species. Therefore, this work aimed to evaluate the acaricidal effect of soursop seed extract (annona muricata L.) on R. indica adults. The experiment was conducted in a completely randomized design using soursop seed extract with 7 replicates and 12 individuals of R. indica per replicate. The experimental units consisted of discs of coconut palm leaves (4 cm in diameter), with cotton moistened at the bottom of the Petri dish (10.0 × 1.2 cm) and around the disc to maintain turgor and prevent mites from escaping. The application was performed using an airbrush, connected to a calibrated compressor with a constant pressure of 1.3 psi and 1 mL of solution per repeat plate. The acaricidal effect was evaluated 24, 48, and 72 hours after spraying. Mortality data were corrected and submitted to Probit analysis (p ≤ 0.05) using the statistical program R, with the LC50 and LC90 calculated for the extract. At the maximum concentration (15%), the soursop seed extract showed mortality of 70% of individuals of R. indica, and the LC50 was 6.58%. It was concluded that the soursop seed extract showed acaricidal potential on R. indica in the laboratory.

关键词： annona muricata Raoiella indica Alternative Control Agro-Industrial Residue

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