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Aqueous suspension of anise “Pimpinella anisum” protects rats against chemically induced gastric ulcers

World Journal of Gastroenterology 2007年第7期13卷 1112-1118页

作者： Ibrahim A Al Mofleh Abdulqader A Alhaider Jaber S Mossa Mohammed O Al-Soohaibani Syed Rafatullah Department of Medicine College of Medicine King Saud University Riyadh Saudi Arabia Department of Pharmacology College of Medicine King Saud University Riyadh Saudi Arabia Department of Pharmacognosy and Medicinal Aromatic and Poisonous Plants Research Center College of Pharmacy King Saud University Riyadh Saudi Arabia Department of Pathology College of Medicine King Saud University Riyadh Saudi Arabia

AIM： To substantiate the claims of Unani and Arabian traditional medicine practitioners on the gastroprotective potential effect of a popular spice anise, ＂Pimpinella anisum L.＂ on experimentally-induced gastric ulceration and secretion in rats. METHODS： Acute gastric ulceration in rats was produced by various noxious chemicals including 80% ethanol, 0.2 mol/L NaOH, 25% NaCI and indomethacin. Anti-secretory studies were undertaken using pylorusligated Shay rat technique. Levels of gastric non-protein sulfhydryls （NP-SH） and wall mucus were estimated and gastric tissue was also examined histologically. anise aqueous suspension was used in two doses （250 and 500 mg/kg body weight） in all experiments. RESULTS： anise significantly inhibited gastric mu- cosal damage induced by necrotizing agents and indomethacin. The anti-ulcer effect was further confirmed histologically. In pylorus-ligated Shay rats, anise suspension significantly reduced the basal gastric acid secretion, acidity and completely inhibited the rumenal ulceration. On the other hand, the suspension significantly replenished ethanol-induced depleted levels of gastric mucosal NP-SH and gastric wall mucus concentration. CONCLUSION： anise aqueous suspension possesses significant cytoprotective and anti-ulcer activities against experimentallynduced gastric lesions. The anti-ulcer effect of anise is possibly prostaglandin-mediated and/orthrough its anti-secretory and antioxidative properties.

关键词： Spice anise Pimpinella anisum Cytopro-tection Gastric ulcer Gastric secretion Sulfhydryls Gastric wall mucus

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