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Comparative studies on fouling of homogeneous Anion exchange membranes by different structured organics in electrodialysis

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Journal of Environmental Sciences 2019年第3期31卷 218-228页

作者： Zhijuan Zhao Shaoyuan Shi Hongbin Cao Yujiao Li Bart Van der Bruggen Division of Environment Technology and Engineering CAS key Laboratory of Green Process and Engineering Beijing Research Center of Process Pollution Control State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Chemical Engineering KU Leuven Zhengzhou Institute of Emerging Industrial Technology Faculty of Engineering and the Built Environment Tshwane University of Technology

Five negatively charged organic compounds with different structures, sodium methane sulfonate(MS), sodium benzene sulfonate(BS), sodium 6-hydroxynaphthalene-2-sulfonate(NSS), sodium dodecyl sulfate(SDS), and sodium dodecyl benzene sulfonate(SDBS), were used to examine the fouling of an Anion exchange membrane(AEM) in electrodialysis(ED),to explore the effect of molecular characteristics on the fouling behavior on the AEM and changes in the surface and electrochemical properties of the AEM. Results indicated that the fouling degree of the AEM by the different organics followed the order:SDBS > SDS > NSS > BS > MS. SDBS and SDS formed a dense fouling layer on the surface of the AEM, which was the main factor in the much more severe membrane fouling, and completely restricted the transmembrane ion migration. The other three organics caused fouling of the AEM by adsorption on the surface and/or accumulation in the interlayer of the AEM, and exhibited almost no influence on the transmembrane ion migration. It was also concluded that the organics with benzene rings caused more severe fouling of the AEM due to the stronger affinity interaction and steric effect between the organics and the AEM compared with organics with aliphatic chains.

关键词： Anion exchange membrane Different structural organics Membrane fouling Property characterization Fouling mechanism analyses

Insulin-like growth factor 1 modulates the phosphorylation, expression, and activity of organic Anion transporter 3 through protein kinase A signaling pathway

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Acta Pharmaceutica Sinica B 2020年第1期10卷 186-194页

作者： Jinghui Zhang Zhou Yu Guofeng You Department of Pharmaceutics RutgersThe State University of New JerseyPiscatawayNJ 08854USA

Organic Anion transporter 3(OAT3)plays a vital role in removing a broad variety of Anionic drugs from kidney,thus avoiding their possible toxicity in the body.In the current study,we investigated the role of insulin-like growth factor 1(IGF-1)in the regulation of OAT3.We showed that IGF-1 induced a dose-and time-dependent increase in OAT3 transport activity,which correlated well with an increase in OAT3 expression.The IGF-1-induced increase in OAT3 expression was blocked by protein kinase A(PKA)inhibitor H89.Moreover,IGF-1 induced an increase in OAT3 phosphorylation,which was also blocked by H89.These data suggest that the IGF-1 modulation of OAT3 occurred through PKA signaling pathway.To further confirm the involvement of PKA,we treated OAT3-expressing cells with PKA activator Bt’2-cAMP,followed by examining OAT activity and phosphorylation.We showed that OAT3 activity and phosphorylation were much enhanced in Bt2-cAMP-treated cells as compared to that in control cells.Finally,linsitinib,an anticancer drug that blocks the IGF-1 receptor,abrogated IGF-1-stimulated OAT3 transport activity.In conclusion,our study demonstrated that IGF-1 regulates OAT3 expression and transport activity through PKA signaling pathway,possibly by phosphorylating the transporter.

关键词： Organic Anion transporter Drug transport Regulation IGF-1 PKA Phosphorylation

Organic Anion transporter 1 and 3 contribute to traditional Chinese medicine-induced nephrotoxicity

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Chinese Journal of Natural Medicines 2020年第3期18卷 196-205页

作者： SHEN Qing-Qing WANG Jing-Jing ROY Debmalya SUN Li-Xin JIANG Zhen-Zhou ZHANG Lu-Yong HUANG Xin Jiangsu Key Laboratory of Drug Screening China Pharmaceutical UniversityNanjing 210009China Jiangsu Center for Pharmacodynamics Research and Evaluation China Pharmaceutical UniversityNanjing 210009China Key Laboratory of Drug Quality Control and Pharmacovigilance Ministry of EducationChina Pharmaceutical UniversityNanjing 210009China Center for Drug Screening and Pharmacodynamics Evaluation School of PharmacyGuangdong Pharmaceutical UniversityGuangzhou 510006China

With the internationally growing popularity of traditional Chinese medicine(TCM), TCM-induced nephropathy has attracted public attention. Minimizing this toxicity is an important issue for future research. Typical nephrotoxic TCM drugs such as Aristolochic acid, Tripterygium wilfordii Hook. f, Rheum officinale Baill, and cinnabar mainly damage renal proximal tubules or cause interstitial nephritis. Transporters in renal proximal tubule are believed to be critical in the disposition of xenobiotics. In this review, we provide information on the alteration of renal transporters by nephrotoxic TCMs, which may be helpful for understanding the nephrotoxic mechanism of TCMs and reducing adverse effects. Studies have proven that when administering nephrotoxic TCMs, the expression or function of renal transporters is altered, especially organic Anion transporter 1 and 3. The alteration of these transporters may enhance the accumulation of toxic drugs or the dysfunction of endogenous toxins and subsequently sensitize the kidney to injury.Transporters-related drug combination and clinical biomarkers supervision to avoid the risk of future toxicity are proposed.

关键词： Traditional Chinese medicine Nephrotoxicity Renal tubular epithelial cell Organic Anion transporter Aristolochic acid Tripterygium wilfordii Hook.f. Rheum officinale Baill

Organic Anion transporters also mediate the drug–drug interaction between imipenem and cilastatin

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Asian Journal of Pharmaceutical Sciences 2020年第2期15卷 252-263页

作者： Yanna Zhu Xiaokui Huo Changyuan Wang Qiang Meng Zhihao Liu Huijun Sun Aiping Tan Xiaodong Ma Jinyong Peng Kexin Liu Department of Clinical Pharmacology College of PharmacyDalian Medical UniversityDalian 116044China College(Institute)of Integrative Medicine Dalian Medical UniversityDalian 116044China Provincial Key Laboratory for Pharmacokinetics and Transport Dalian Medical UniversityDalian 116044China Department of Pharmacy First Affiliated Hospital of Dalian Medical UniversityDalian 116011China

This study aimed to clarify that organic Anion transporters(OATs)mediate the drug–drug interaction(DDI)between imipenem and cilastatin.After co-administration with imipenem,the plasma concentrations and the plasma concentration-time curve(AUC)of cilastatin were significantly increased,while renal clearance and cumulative urinary excretion of cilastatin were decreased.At the same time,imipenem significantly inhibited the uptake of cilastatin in rat kidney slices and in human OAT1(hOAT1)-HEK293 and human OAT3(hOAT3)-HEK293 cells.Probenecid,p-aminohippurate,and benzylpenicillin inhibited the uptake of imipenem and cilastatin in rat kidney slices and in hOAT1-and hOAT3-HEK 293 cells,respectively.The uptakes of imipenem and cilastatin in hOAT1-and hOAT3-HEK 293 cells were significantly higher than that in mock-HEK-293 cells.Moreover,the K m values of cilastatin were increased in the presence of imipenem with unchanged V max,indicating that imipenem inhibited the uptake of cilastatin in a competitive manner.When imipenem and cilastatin were co-administered,the level of imipenem was higher compared with imipenem alone both in vivo and in vitro.But,cilastatin significantly inhibited the uptake of imipenem when dehydropeptidase-1(DPEP1)was silenced by RNAi technology in hOAT1-and hOAT3-HEK 293 cells.In conclusion,imipenem and cilastatin are the substrates of OAT1 and OAT3.OAT1 and OAT3 mediate the DDI between imipenem and cilastatin.Meanwhile,cilastatin also reduces the hydrolysis of imipenem by inhibiting the uptake of imipenem mediated by OAT1 and OAT3 in the kidney as a complement.

关键词： Imipenem/cilastatin Renal dipeptidase Organic Anion transporters Drug-drug interaction

Piperacillin enhances the inhibitory effect of tazobactam on β-lactamase through inhibition of organic Anion transporter 1/3 in rats

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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 677-686页

作者： Shilei Yang Zhihao Liu Changyuan Wang Shijie Wen Qiang Meng Xiaokui Huo Huijun Sun Xiaodong Ma Jinyong Peng Zhonggui He Kexin Liu Department of Clinical Pharmacology College of PharmacyDalian Medical UniversityDalian 116044China Provincial Key Laboratory for Pharmacokinetics and Transport Dalian Medical UniversityDalian 116044China Department of pharmacy First Affiliated Hospital of Dalian Medical UniversityDalian 116044China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China College(Institute)of Integrative Medicine Dalian Medical UniversityDalian 116044China

To assess the mechanism of the pharmacokinetic interaction between piperacillin and tazobactam,renal excretion and pharmacokinetic studies of piperacillin/tazobactam were investigated in normal and bacteremia rats.A bacteremia model was established to investigate the pharmacokinetic properties of piperacillin and tazobactam under different conditions.Renal slices were taken to examine the uptake of piperacillin and tazobactam.Pharmacokinetic studies ofβ-lactamase in rats were performed to study the contribution of rOat1/3 to the inhibition of tazobactam onβ-lactamase.The AUC(from 2.93±0.58 to 6.52±1.44 mg·min/ml)and the plasma clearance(CL P)(from 2.41±1.20 to 0.961±0.212 ml/min/kg)of tazobactam were both altered after the intravenous coadministration of piperacillin and tazobactam in the bacteremia rats.The renal clearance(CL R)of tazobactam decreased from 1.30±0.50 to 0.361±0.043 ml/min/kg.In summary,there was a beneficial interaction between piperacillin and tazobactam mediated by rOat1 and rOat3.Piperacillin enhances the inhibitory effect of tazobactam onβ-lactamase through the inhibition of rOat1 and rOat3 in rats.The contribution rate of rOat1/3 for the synergistic effect was 20%when the two drugs were coadministered.

关键词： Organic Anion transporter Piperacillin Tazobactam Drug-drug interaction

The synthesis and structure of pyridine-oxadiazole iridium complexes and catalytic applications:Non-coordinating-Anion-tuned selective C—N bond formation

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Chinese Chemical Letters 2020年第3期31卷 701-705页

作者： Wei Yao Yilin Zhang Haiyan Zhu Chenyang Ge Dawei Wang Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China C.Eugene Bennett Department of Chemistry West Virginia UniversityMorgantownWV 26506United States

Several novel pyridine-oxadiazole iridium complexes were synthesized and characterized through X-ray crystallography.The designed iridium.complexes revealed surprisingly high catalytic activity in C-N bondformation of amides and benzyl alcohols with the assistance of non-coordinating Anions.In an attempt to achieve borrowing hydrogen reactions of amides with benzyl alcohols,N,N'-(phenylmethylene)dibenzamide products we re unexpectedly isolated under non-coordinating Anion conditions,whereas N-benzylbenzamide products were achieved in the absence of non-coordinating Anions.The mechanism explorations excluded the possibility of"silver effect"(silver-assisted or bimetallic catalysis)and revealed that the reactivity of iridium catalyst was varied by non-coordinating Anions.This work provided a convenient and useful methodology that allowed the iridium complex to be a chemoselective catalyst and demonstrated the first example of non-coordinating-Anion-tuned selective C-N bond formation.

关键词： Borrowing hydrogen Dehydrogenation Non-coordinating Anion Iridium Bisamides

Regression model for stabilization energies associated with Anion ordering in perovskite-type oxynitrides

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Journal of Energy Chemistry 2019年第9期28卷 7-14页

作者： Masanori Kaneko Mikiya Fujii Takashi Hisatomi Koichi Yamashita Kazunari Domen Department of Chemical System Engineering School of Engineering The University of Tokyo7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan Center for Energy & Environmental Science Interdisciplinary Cluster for Cutting Edge Research Shinshu University4-17-1 Wakasato Nagano-shi Nagano 380-8553 Japan

Certain perovskite-type oxynitrides have bandgaps suitable for renewable hydrogen production via photocatalytic and photoelectrochemical water splitting under visible light.Understanding the ordering of oxide and nitride Anions in these materials is important because this ordering affects their semiconductor properties.However, the numerous possible orderings complicate systematic analyses based on density functional theory(DFT) calculations using defined elemental arrangements.This work shows that Anion ordering in large-scale supercells within perovskite-type oxynitrides can be rapidly predicted based on machine learning, using BaNbO2N(capable of oxidizing water under irradiation up to 740 nm) as an example.Machine learning allows the calculation of the total energy of BaNbO2N directly from randomly selected initial atomic placements without costly structural optimization, thus reducing the computational cost by more than 99.99%.Combined with the Metropolis Monte Carlo method, machine learning permits exploration of the stable Anion orderings of large supercells without costly DFT calculations.This work therefore demonstrates a means of predicting the properties of functional materials having complex compositions based on the most realistic elemental arrangements in conjunction with reasonable computational loads.

关键词： Machine learning Total energy Bandgap Local Anion ordering Density functional theory

Overview of organic Anion transporters and organic Anion transporter polypeptides and their roles in the liver

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World Journal of Clinical Cases 2019年第23期7卷 3915-3933页

作者： Ting-Ting Li Jia-Xing An Jing-Yu Xu Bi-Guang Tuo Department of Gastroenterology Affiliated Hospital Zunyi Medical University

Organic Anion transporters(OATs)and organic Anion transporter polypeptides(OATPs)are classified within two SLC superfamilies,namely,the SLC22A superfamily and the SLCO superfamily(formerly the SLC21A family),respectively.They are expressed in many tissues,such as the liver and kidney,and mediate the absorption and excretion of many endogenous and exogenous substances,including various drugs.Most are composed of 12 transmembrane polypeptide chains with the C-terminus and the N-terminus located in the cell cytoplasm.OATs and OATPs are abundantly expressed in the liver,where they mainly promote the uptake of various endogenous substrates such as bile acids and various exogenous drugs such as antifibrotic and anticancer drugs.However,differences in the locations of glycosylation sites,phosphorylation sites,and amino acids in the OAT and OATP structures lead to different substrates being transported to the liver,which ultimately results in their different roles in the liver.To date,few articles have addressed these aspects of OAT and OATP structures,and we study further the similarities and differences in their structures,tissue distribution,substrates,and roles in liver diseases.

关键词： Organic Anion Substrate transport Liver fibrosis Liver cirrhosis Liver cancer Targeted therapy

Anion charge and lattice volume dependent lithium ion migration in compounds with fcc Anion sublattices

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npj Computational Materials 2020年第1期6卷 1280-1287页

作者： Zhenming Xu Xin Chen Ronghan Chen Xin Li Hong Zhu University of Michigan–Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China School of Materials Science and Engineering Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Harvard John.A.Paulson School of Engineering and Applied Sciences Harvard University29 Oxford StreetCambridgeMA 02138USA

Proper design principles are essential for the efficient development of superionic conductors.However,the existing design principles are mainly proposed from the perspective of crystal structures.In this work,the face-centered cubic(fcc)Anion sublattices were creatively constructed to study the effects of Anion charge and lattice volume on the stability of lithium ion occupation and lithium ion migration by the density functional theory calculations.Both the large negative Anion charges and large lattice volumes would increase the relative stabilities of lithium-Anion tetrahedron,making lithium ions prefer to occupy the tetrahedral sites.

关键词： lithium Anion lattice