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Towards magnetism in pigeon MagR: Iron- and iron-sulfur binding work indispensably and synergistically

Zoological Research 2023年第1期44卷 142-152页

作者： Yajie Zhou Tianyang Tong Mengke Wei Peng Zhang Fan Fei Xiujuan Zhou Zhen Guo Jing Zhang Huangtao Xu Lei Zhang Shun Wang Junfeng Wang Tiantian Cai Xin Zhang Can Xie Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230039China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui 230031China Department of Anatomy Anhui Medical UniversityHefeiAnhui 230032China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China School of Life Sciences Peking UniversityBeijing 100871China International Magnetobiology Frontier Research Center Science IslandHefeiAnhui 230031China Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School250 Longwood AvenueBostonMA 02115USA

The ability to navigate long distances is essential for many animals to locate shelter,food,and breeding grounds.Magnetic sense has evolved in various migratory and homing species to orient them based on the geomagnetic field.A highly conserved ironsulfur cluster assembly protein IscA is proposed as an animal magnetoreceptor(MagR).Iron-sulfur cluster binding is also suggested to play an essential role in MagR magnetism and is thus critical in animal magnetoreception.In the current study,we provide evidence for distinct iron binding and iron-sulfur cluster binding in MagR in pigeons,an avian species that relies on the geomagnetic field for navigation and homing.Pigeon MagR showed significantly higher total iron content from both iron-and ironsulfur binding.Y65 in pigeon MagR was shown to directly mediate mononuclear iron binding,and its mutation abolished iron-binding capacity of the protein.Surprisingly,both iron binding and iron-sulfur binding demonstrated synergistic effects,and thus appear to be integral and indispensable to pigeon MagR magnetism.These results not only extend our current understanding of the origin and complexity of MagR magnetism,but also imply a possible molecular explanation for the huge diversity in animal magnetoreception.

关键词： animal magnetoreception Iron-sulfur cluster binding Iron binding Magnetism Magnetoreceptor(MagR)

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