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Production of Soybean Oil Nanoemulsion (SONE) and Evaluation of Angiogenic and Embryotoxic Activity

Journal of Biomaterials and Nanobiotechnology 2020年第3期11卷 161-178页

作者： Tamíris Augusto Marinho Patrícia Silva Nunes Paulo Roberto de Melo-Reis Mônica Rodrigues Ferreira Machado Nelson Jorge Silva Júnior Programa de Pós-Graduaç o Doutorado em Biotenologia e Biodiversidade (PGBB) Universidade Federal de Goiás (UFG) Goiania Brasil Núcleo de Estudos e Pesquisas em Promoç o da Saúde (NUPPS) Instituto Federal de Educa&#231 o Ciência e Tecnologia de Goiás (IFG) Goiania Brasil Programa de Pós-Graduaç o Mestrado em Genética Goiania Brasil Departamento de Ciências Biológicas Laboratório de Pesquisa e Reprodu&#231 o de Zebrafish (LABFISH) Universidade Federal de Jataí (UFJ) Jataí Brasil

The SONE oil/water was prepared using the pseudo-ternary phase diagram, using a low energy method with phase inversion by changing the composition. In order to optimize the preparation of SONE, three speeds were used in the agitator arm and two different rods. The particle size and polydispersity index were determined by Dynamic Light Scattering (DLS) and the stability test by the freeze-thaw cycle. angiogenesis in chicken embryo egg chorioallantoic membrane and zebrafish (Danio rerio) embryotoxicity was performed. The lower stirring speed and propeller shaft induced smaller particle size (550.2 nm). Regarding angiogenesis, there was a statistically significant difference for all the evaluated parameters (length, caliber, junctions, and number of blood vessel complexes) and the result was higher in SONE when compared to the inhibition control (Dexamethasone), but lower than the induction control (Regederm®) and there was no statistically significant difference between SONE and distilled water. It was observed that the exposure of the zebrafish embryos to SONE caused an increase in the mortality rate dependent on time and concentration. The LC50 for SONE decreased statistically with increasing exposure (p-value = 0.046). Heart rate decreased significantly with increasing concentration at all exposure times (p-value < 0.05), as a result of progressive embryo mortality. The hatching rate was late until the concentration of 0.0193 mg/mL and no hatching rate was verified from that concentration. Exposure of zebrafish embryos to different concentrations of SONE induced malformations such as spinal changes, pericardial edema and yolk sac edema, but there was no significant difference in the malformation rate of embryos exposed to SONE when compared to the control group. The SONE produced remained stable in the freeze-thaw cycle, with c

关键词： Soybean Oil angiogenesis inducing agents Toxicity Biotechnology Nanotechnology

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Criculating fibrocytes： a potent cell population in antigen-presenting and wound healing

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Chinese Journal of Traumatology 2010年第2期13卷 111-116页

作者：范霞梁华平 State Key Laboratory of Trauma Burn and Combined Injury Research Institute of Surgery Daping Hospital Third Military Medical University Chongqing 400042 China

Fibrocytes are bone marrow-derived mesenchymal progenitors that co-express hematopoietic cell antigens and markers of monocytic lineage as well as fibroblast products. During wound healing, fibrocytes have been found to possess the ability of antigen-presentation to naive T cells in the inflammatory phase. Moreover, they can promote the endothelial cell proliferation, migration and angiogenesis by secreting several proteins. Fibrocytes can further differentiate into mature mesenchymocyte lineage, such as fibroblasts, myofibroblasts and adipocytes, and they may represent the systemic source of myofibroblasts that exert a contractile force required to close tissue wounds. A deep understanding of the mechanism involved in fibrocyte migration and differentiation may lead to the development of a novel theory of normal physiology and pathology.

关键词： Wound healing Antigen-presenting cells angiogenesis inducing agents

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