检索结果-南通市图书馆

Impacts of androgen deprivation therapy on the risks and outcomes of SARS-CoV-2 infection in patients with prostate cancer

引用

Asian Journal of Andrology 2023年第3期25卷 366-374页

作者： Yuan-Bin Huang Wei-Lin Li Man Sun Xu Duan Yu-Tong Wang Lu-Xin Zhang Zi-Han Xin Zhi-Fei Yun Bo Fan Xian-Cheng Li Department of Urology Second Affiliated Hospital of Dalian Medical UniversityDalian 116000China Second Clinical College Dalian Medical UniversityDalian 116000China First Clinical College Dalian Medical UniversityDalian 116000China Department of Nephrology Sino-Japanese Friendship Hospital of Jilin UniversityChangchun 130031China

Studies have investigated the effects of androgen deprivation therapy(ADT)use on the incidence and clinical outcomes of coronavirus disease 2019(COVID-19);however,the results have been *** searched the PubMed,Medline,Cochrane,Scopus,and Web of Science databases from inception to March 2022;13 studies covering 84003 prostate cancer(PCa)patients with or without ADT met the eligibility criteria and were included in the *** calculated the pooled risk ratios(RRs)with 95%confidence intervals(CIs)to explore the association between ADT use and the infection risk of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and severity of *** synthesizing the evidence,the pooled RR in the SARS-CoV-2 positive group was equal to 1.17,and the SARS-CoV-2 positive risk in PCa patients using ADT was not significantly different from that in those not using ADT(P=0.544).Moreover,no significant results concerning the beneficial effect of ADT on the rate of intensive care unit admission(RR=1.04,P=0.872)or death risk(RR=1.23,P=0.53)were ***,PCa patients with a history of ADT use had a markedly higher COVID-19 hospitalization rate(RR=1.31,P=0.015)than those with no history of ADT *** findings indicate that ADT use by PCa patients is associated with a high risk of hospitalization during infection with SARS-CoV-2.A large number of high quality studies are needed to confirm these results.

关键词： androgen deprivation therapy coronavirus disease 2019 meta-analysis prostate cancer severe acute respiratory syndrome coronavirus 2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Complete androgen blockade *** castration alone as adjuvant androgen deprivation therapy for prostate cancer patients following radical prostatectomy:a retrospective cohort study

引用

Chinese Medical Journal 2022年第7期135卷 820-827页

作者： Di Jin Kun Jin Bo Chen Xianghong Zhou Qiming Yuan Zilong Zhang Qiang Wei Shi Qiu Department of Urology West China Hospital of Sichuan UniversityChengduSichuan 610041China Center of Biomedical Big Data West China Hospital of Sichuan UniversityChengduSichuan 610041China West China School of Medicine West China Hospital of Sichuan UniversityChengduSichuan 610041China Institute of Urology West China Hospital of Sichuan UniversityChengduSichuan 610041China

Background:Till date,the optimal treatment strategy for delivering adjuvant androgen deprivation therapy(ADT)in localized and locally advanced prostate cancer(PCa),as a lower stage in PCa progression compared with metastatic PCa,is still *** study compares the efficacy of castration alone with complete androgen blockade(CAB)as adjuvant ADT in patients with localized and locally advanced PCa undergoing radical prostatectomy(RP).Methods:Patients diagnosed with PCa,without lymph node or distant metastasis,who received RP in West China Hospital between January 2009 and April 2019,were enrolled in this *** performed survival,multivariable Cox proportional hazard regression,and subgroup ***:A total of 262 patients were enrolled,including 107 patients who received castration alone and 155 patients who received *** survival analysis revealed that there was no significant difference between the two groups(hazard ratios[HR]=1.07,95%confidence intervals[95%CI]=0.60-1.90,P=0.8195).Moreover,the multivariable Cox model provided similarly negative results before and after adjustment for potential ***,there was no significant difference in the clinical recurrence between the two groups in both non-adjusted and adjusted ***,our subgroup analysis showed that CAB achieved better biochemical recurrence(BCR)outcomes than medical castration alone as adjuvant ADT for locally advanced PCa(P for interaction=0.0247,HR=0.37,95%CI=0.14-1.00,P=0.0497).Conclusion:Combined androgen blockade achieved better BCR outcomes compared with medical castration alone as adjuvant ADT for locally advanced PCa without lymph node metastasis.

关键词： Prostatic neoplasms androgens therapy Recurrence androgen deprivation therapy Complete androgen blockade

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Radiomics based on biparametric MRI for the detection of significant residual prostate cancer after androgen deprivation therapy:using whole-mount histopathology as reference standard

引用

Asian Journal of Andrology 2023年第1期25卷 86-92页

作者： Zhang-Zhe Chen Wei-Jie Gu Bing-Ni Zhou Wei Liu Hua-Lei Gan Yong Zhang Liang-Ping Zhou Xiao-Hang Liu Department of Radiology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical College of Fudan UniversityShanghai 200032China Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China MR Research GE HealthcareShanghai 200032China

We aimed to study radiomics approach based on biparametric magnetic resonance imaging(MRI)for determining significant residual cancer after androgen deprivation therapy(ADT).Ninety-two post-ADT prostate cancer patients underwent MRI before prostatectomy(62 with significant residual disease and 30 with complete response or minimum residual disease[CR/MRD]).Totally,100 significant residual,52 CR/MRD lesions,and 70 benign tissues were selected according to ***,381 radiomics features were extracted from T2-weighted imaging,diffusion-weighted imaging,and apparent diffusion coefficient(ADC)*** features were selected using a support vector machine with a recursive feature elimination algorithm(SVM-RFE).Then,ADC values of significant residual,CR/MRD lesions,and benign tissues were compared by one-way analysis of *** regression was used to construct models with SVM features to differentiate between each pair of ***,the efficiencies of ADC value and radiomics models for differentiating the three tissues were assessed by area under receiver operating characteristic curve(AUC).The ADC value(mean±standard deviation[s.d.])of significant residual lesions([1.10±0.02]×10^(-3)mm^(2)s^(−1))was significantly lower than that of CR/MRD([1.17±0.02]×10^(-3)mm^(2)s^(−1)),which was significantly lower than that of benign tissues([1.30±0.02]×10^(-3)mm^(2)s^(−1);both P0.05),but superior to ADC value in differentiating significant residual from CR/MRD(AUC:0.748 vs 0.558;P=0.041).Radiomics approach with biparametric MRI could promote the detection of significant residual prostate cancer after ADT.

关键词： androgen deprivation therapy diffusion-weighted imaging prostate cancer radiomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dissecting the effects of androgen deprivation therapy on cadherin switching in advanced prostate cancer: A molecular perspective

引用

Oncology Research 2022年第3期30卷 137-155页

作者： LOKMAN VARISLI VEYSEL TOLAN JIYAN H.CEN SPIROS VLAHOPOULOS OSMAN CEN Department of Molecular Biology and Genetics Science FacultyDicle UniversityDiyarbakir21280Turkey Cancer Research Center Dicle UniversityDiyarbakir21280Turkey Department of Chemical and Biomolecular Engineering University of IllinoisUrbanaIL61801USA First Department of Pediatrics National and Kapodistrian University of AthensAthens11527Greece Department of Microbiology and Immunology Feinberg School of MedicineNorthwestern UniversityChicagoIL60611USA Department of Natural Sciences and Engineering John Wood CollegeQuincyIL62305USA

Prostate cancer is one of the most often diagnosed malignancies in males and its prevalence is rising in both developed and developing *** deprivation therapy has been used as a standard treatment approach for advanced prostate cancer for more than 80 *** primary aim of androgen deprivation therapy is to decrease circulatory androgen and block androgen *** a partly remediation is accomplished at the beginning of treatment,some cell populations become refractory to androgen deprivation therapy and continue to *** evidences suggest that androgen deprivation therapy may cause cadherin switching,from E-cadherin to N-cadherin,which is the hallmark of epithelial-mesenchymal *** direct and indirect mechanisms are involved in this switching and consequently,the cadherin pool changes from E-cadherin to N-cadherin in the epithelial *** E-cadherin represses invasive and migrative behaviors of the tumor cells,the loss of E-cadherin disrupts epithelial tissue structure leading to the release of tumor cells into surrounding tissues and *** this study,we review the androgen deprivation therapy-dependent cadherin switching in advanced prostate cancer with emphasis on its molecular basis especially the transcriptional factors regulated through TFG-βpathway.

关键词： Prostate cancer androgen signaling androgen deprivation therapy Cadherin switching

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

androgen deprivation therapy through bilateral orchiectomy, increased metabolic risks

引用

Asian Journal of Andrology 2011年第6期13卷 833-837页

作者： Juan-Jie Bo Chao Zhang Lian-Hua Zhang Ping Liu Jian-Jun Sha Jian-Wei Lv Dong-Ming Liu Yi-Ran Huang Zheng Li Department of Urology Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai 200001 China

Prostate cancer is one of the most common malignancies in men. Previous research has determined that androgen deprivation therapy （ADT） may be accompanied by an unfavourable metabolic profile. In this prospective study, 133 men were recruited, including 46 prostate cancer patients who had undergone bilateral orchiectomy and been on flutamide （the ADT group）, 37 men with prostate cancer who had undergone radical prostatectomy （the non-ADT group） and 50 normal control subjects （the control group）. All subjects were followed for at least 12 months. From baseline to 3 months, men in the ADT group had increased levels of fasting serum insulin and low-density lipoprotein compared to the other two groups （P〈0.05）. No obvious changes were found in the other parameters （P〉0.05）. After 12 months, men in the ADT group had increased levels of waist circumference, fasting serum insulin and glucose, total cholesterol, high-density lipoprotein and low-density lipoprotein compared to the other two groups （P〈0.05）. Additionally, the morbidity rate of metabolic syndrome in the ADT group was higher （P〈0.05） compared to the other two groups. ADT through surgical castration for men with prostate cancer may be associated with unfavourable metabolic changes. The benefits of the therapy should be balanced prudently against these risks.

关键词： androgen deprivation therapy bilateral orchiectomy metabolic changes metabolic syndrome prostate cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

androgen deprivation therapy-associated vasomotor symptoms

引用

Asian Journal of Andrology 2012年第2期14卷 193-197页

作者： Jason M Jones Manish Kohli Charles L Loprinzi Department of Medical Oncology Mayo Clinic Rochester MN 55905 USA

androgen deprivation therapy （ADT） is widely used as standard therapy in the treatment of locally advanced and metastatic prostate cancer. While efficacious, ADT is associated with multiple side effects, including decreased libido, erectile dysfunction, diabetes, loss of muscle tone and altered body composition, osteoporosis, lipid changes, memory loss, gynecomastia and hot flashes. The breadth of literature for the treatment of hot flashes is much smaller in men than that in women. While hormonal therapy of hot flashes has been shown to be effective, multiple non-hormonal medications and treatment methods have also been developed. This article reviews current options for the treatment of hot flashes in patients taking ADT.

关键词： androgen deprivation therapy hot flashes vasomotor symptoms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development and Initial Validation of the Novel Scale for Assessing Quality of Life of Prostate Cancer Patients Receiving androgen deprivation therapy

引用

Chinese Medical Journal 2017年第17期130卷 2082-2087页

作者： Yao-Jun Dun Hui-Xin Liu Lu-Ping Yu Qing Li Xiao-Wei Zhang Xu Tang Cai-Peng Qin Tao Xu Department of Urology Peking University People&#39 s Hospital Beijing 100044 China Department of Clinical Epidemiology Peking University People&#39 s Hospital Beijing 100044 China Department of Urology Peking University International Hospital Beijing 102206 China

Background：There has been no a specific scale to measure quality of life （QOL） for prostate cancer patients receiving androgen deprivation therapy （ADT） to *** study aimed to develop and initially validate the scale to evaluate QOL for prostate cancer patients receiving ***：The scale was developed following international ***,the items were all generated through literature review and referenced *** being reviewed by expert panelists,the revised scale was formed and then completed by a convenience sample of 200 prostate cancer patients from our *** factor analysis （EFA） was applied to test the construct validity,then split-half reliability,Cronbach＆#39;s alpha,and test-retest reliability were applied to assess the reliability and stability of the ***：The revised scale contained 22 items and a total of 200 participants had completed the *** hundred participants were randomly selected from the total 200 participants to perform EFA with varimax rotation on the revised scale,and ＆quot;hot flashes＆quot; item was deleted for low factor *** selected only 3 items from each factor,then,the final scale was formed with *** selected another 100 participants to perform the EFA again on the final *** was demonstrated that the structure with 6 factors explained 72.5% of total variance and factor loading value was above 0.40 in all items of the ***,the split-half reliability coefficient,Cronbach＆#39;s alpha,and test-retest reliability coefficient were calculated to be 0.74,0.63,and 0.89,respectively,exhibiting good reliability on the ***：The scale was identified to be a valid and reliable instrument to measure QOL for prostate cancer patients receiving ***,further research is needed to overcome the potential drawbacks.

关键词： androgen deprivation therapy Exploratory Factor Analysis Prostate Cancer Quality of Life Scale

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of androgen deprivation therapy on sexua function

引用

Asian Journal of Andrology 2012年第2期14卷 198-203页

作者： Clarisse R Mazzola John P Mulhall Sexual and Reproductive Medicine Program Urology ServiceMemorial SIoan Kettering Cancer CenterNew YorkNY 10065USA

Many patients with prostate cancer for whom androgen deprivation therapy （ADT） is indicated are young and desire to remain sexually active. In such patients, the side effects of androgen therapy on sexual function can be a source of serious reduction in overall quality of life. Providing the appropriate treatment options in this patient population is therefore essential. Nevertheless, treating such patients is challenging and an understanding of the underlying mechanisms of sexual physiology and pathophysiology is crucial to optimal patient care. In this paper, we reviewed what was known regarding the effects of ADT on sexual function in animal models and we also provided a detailed review on the effects of ADT on sexual health in humans and its treatment.

关键词： androgen deprivation therapy castration ejaculation erectile dysfunction orgasm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Use of androgen deprivation therapy in prostate cancer： indications and prevalence

引用

Asian Journal of Andrology 2012年第2期14卷 177-186页

作者： Roisin M Connolly Michael A Carducci Emmanuel S Antonarakis Prostate Cancer Research Program Department of Medical Oncology Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore MD 21231-1000 USA

androgens play a prominent role in the development, maintenance and progression of prostate cancer. The introduction of androgen deprivation therapies into the treatment paradigm for prostate cancer patients has resulted in a wide variety of benefits ranging from a survival advantage for those with clinically localized or locally advanced disease, to improvements in symptom control for patients with advanced disease. Controversies remain, however, surrounding the optimal timing, duration and schedule of these hormonal approaches. Newer hormonal manipulations such as abiraterone acetate have also been investigated and will broaden treatment options for men with prostate cancer, This review highlights the various androgen-directed treatment options available to men with prostate cancer, their specific indications and the evidence supporting each approach, as well as patterns of use of hormonal therapies.

关键词： androgen deprivation therapy androgen synthesis anti-androgen prostate cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Serum testosterone level predicts the effective time of androgen deprivation therapy in metastatic prostate cancer patients

引用

Asian Journal of Andrology 2017年第2期19卷 178-183页

作者： Yue Wang Bo Dai Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer Center Shanghai 20032 China Department of Oncology Shanghai Medical College Fudan University Shanghai 20032 China

androgen deprivation therapy （ADT） is the standard of care for patients with metastatic prostate cancer. However, whether serum testosterone levels, using a cut-off point of 50 ng d1-1, are related to the effective time of ADT in newly diagnosed prostate cancer patients remains controversial. Moreover, recent studies have shown that some patients may benefit from the addition of upfront docetaxel chemotherapy. To date, no studies have been able to distinguish patients who will benefit from the combination of ADT and docetaxel chemotherapy. This study included 206 patients who were diagnosed with metastatic prostate cancer and showed progression to castrate-resistance prostate cancer （CRPC）. Serum testosterone levels were measured prospectively after ADT for 1, 3, and 6 months. The endpoint was the time to CRPC. In univariate and multivariate analyses, testosterone levels 〈50 ng d1-1 were not associated with the effective time of ADT. Receiver operating characteristic and univariate analysis showed that testosterone levels of 〈25 ng d1-1 after the first month of ADT offered the best overall sensitivity and specificity for prediction of a longer time to CRPC （adjusted hazard ratio [HR], 1.46; 95% confidence interval [95% CI], 1.08-1.96; P = 0.013）. Our results show that serum testosterone level of 25 ng d1-1 plays a prognostic role in prostate cancer patients receiving ADT. A testosterone value of 25 ng dl-~ after the first month of ADT can distinguish patients who benefit from ADT effectiveness for only a short time. These patients may need to receive ADT and concurrent docetaxel chemotherapy.

关键词： androgen deprivation therapy metastatic prostate cancer testosterone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：