检索结果-南通市图书馆

Primary anaplastic lymphoma kinase-positive large B-cell lymphoma of the left bulbar conjunctiva: A case report

World Journal of Clinical Cases 2024年第3期12卷 657-664页

作者： Xiao-Hong Guo Chu-Bin Li Hui-Hui Cao Gen-Yuan Yang Department of Pathology Zhuhai People's Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519000Guangdong ProvinceChina Endoscopy Center Zhuhai People's Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519000Guangdong ProvinceChina

BACKGROUND anaplastic lymphoma kinase(ALK)-positive large B-cell lymphoma(LBCL)is an aggressive and rare variant of diffuse LBCL.Herein,we report an uncommon case of stage IE extranodal ALK-positive LBCL initially originating in the bulbar con-junctiva.CASE SUMMARY A 63-year-old woman presented with a mass in the left bulbar conjunctiva that had persisted for six months,accompanied by swelling and pain that had per-sisted for 3 d.Eye examination revealed an 8 mm slightly elevated pink mass in the lower conjunctival sac of the left eye.Microscopically,the tumor was com-posed of large immunoblastic and plasmablastic large lymphoid cells with scattered anaplastic or multinucleated large cells.Immunophenotypically,the neoplastic cells were positive for ALK,CD10,CD138,Kappa,MUM1,BOB.1,OCT-2,CD4,CD45,EMA,CD79a,CD38,and AE1/AE3,and negative for CD20,PAX5,Lambda,BCL6,CD30 and all other T-cell antigens.The results of gene rearrangement tests showed monoclonal IGH/IGK/IGL and TCRD rearran-gements.Fluorescence in situ hybridization studies did not reveal any BCL2,BCL6 or MYC rearrangements.Furthermore,Epstein-Barr virus was not detected by in situ hybridization in the lesions.Based on the histopathological and imaging examinations,the neoplasm was classified as stage IE ALK-positive LBCL.No further treatments were administered.At the 6,15,and 21 mo postoperative follow-up visits,the patient was in good condition,without obvious discomfort.This case represents the first example of primary extranodal ALK-positive LBCL presenting as a bulbar conjunctival mass,which is extremely rare and shares morphological and immunohistochemical features with a variety of other neo-plasms that can result in misdiagnosis.CONCLUSION Awareness of the condition presented in this case report is necessary for early and accurate diagnosis and appropriate treatment.

关键词： anaplastic lymphoma kinase Large B-cell lymphoma Conjunctiva Immunoglobulin/T-cell receptor gene Immunohistochemistry Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pathological complete response to neoadjuvant alectinib in unresectable anaplastic lymphoma kinase positive non-small cell lung cancer:A case report

引用

World Journal of Clinical Cases 2023年第22期11卷 5322-5328页

作者： Lu-Ming Wang Peng Zhao Xu-Qi Sun Feng Yan Qian Guo Department of Thoracic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310002Zhejiang ProvinceChina Department of Medical Oncology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310002Zhejiang ProvinceChina Department of Medical Oncology The First People’s Hospital of Hangzhou Lin’an DistrictHangzhou 311300Zhejiang ProvinceChina

BACKGROUND The development of anaplastic lymphoma kinase(ALK)-tyrosine kinase inhibitors(TKIs)has remarkably improved the prognosis of patients with ALK-positive advanced non-small cell lung cancer(NSCLC).Alectinib,the second-generation ALK-TKI,has been approved as first-line treatment for advanced or metastatic NSCLC patients with ALK rearrangement.Neoadjuvant therapy can achieve tumor downstaging and eradicate occult lesions in patients with potentially resectable disease.Whether neoadjuvant alectinib can be a conversion therapy in ALK-positive advanced NSCLC patients remains unclear.CASE SUMMARY A 41-year-old man was pathologically diagnosed with locally advanced ALKpositive stage IIIB NSCLC.Alectinib was prescribed to induce tumor downstaging and facilitate the subsequent surgical resection.The tumor was successfully downstaged and pathological complete response was achieved.Left upper lobectomy with mediastinal lymphadenectomy was performed after tumor downstaging.The patient has continued to receive alectinib as adjuvant therapy during postoperative follow-up with a recurrence-free survival of 29 mo as of writing this report.CONCLUSION This case sheds light on the feasibility and safety of alectinib as a neoadjuvant treatment for stage IIIB NSCLC patients with ALK rearrangement.Its efficacy needs to be validated in prospective clinical trials.

关键词： Alectinib anaplastic lymphoma kinase Non-small cell lung cancer Neoadjuvant therapy Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acute leukemic phase of anaplastic lymphoma kinase-anaplastic large cell lymphoma: A case report and review of the literature

引用

World Journal of Clinical Cases 2020年第21期8卷 5439-5445页

作者： Huai-Feng Zhang Yan Guo Department of Hematology The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina

BACKGROUND anaplastic large cell lymphoma(ALCL)is a rare and heterogeneous malignant tumor,which is classied as anaplastic lymphoma kinase(ALK)positive ALCL and ALK-ALCL.Many patients are diagnosed with ALCL at the stage of bone marrow involvement.However,ALCL patients with clinical manifestations consistent with acute leukemia are relatively rare.CASE SUMMARY In this report,the patient did not receive appropriate diagnosis and treatment despite a two-year history of lymph node enlargement.Hereafter,she was admitted for B symptoms and was diagnosed as ALK-ALCL by lymph node biopsy.Then,the disease progressed to leukemia without any treatment after 2 mo.The proportion of lymphoma cells in bone marrow was as high as 96%,and the proportion of peripheral blood was 84%.She also had clinical manifestations similar to acute leukemia.After completion of chemotherapy,she developed granulocytopenia and fever and died from septicemia.CONCLUSION ALCL with leukemic presentation is a late manifestation of lymphoma with low chemotherapy tolerance and poor prognosis.

关键词： anaplastic large cell lymphoma anaplastic lymphoma kinase Prognosis Leukemic phase Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of an anaplastic lymphoma kinase pathway signature with cell de-differentiation, neoadjuvant chemotherapy response, and recurrence risk in breast cancer

引用

Cancer Communications 2020年第9期40卷 422-434页

作者： Dingxie Liu Yong Wu Bluewater Biotech LLC New ProvidenceMandaluyongNJ 07974USA Division of Cancer Research and Training Department of Internal MedicineCharles R.Drew University of Medicine and ScienceLos AngelesCA 90059USA David Geffen UCLA School of Medicine and UCLA Jonsson Comprehensive Cancer CenterLos AngelesCA 90059USA

Background:Aberrant activation of anaplastic lymphoma kinase(ALK)signaling has been found to be involved in the tumorigenesis of multiple types of cancer.The aim of this study was to determine the role of this pathway in the pathogenesis of breast cancer.Methods:An ALK pathway signature that we generated previously was used to compute the ALK pathway activity in 6381 breast cancer samples from 42 microarray datasets,and the associations between ALK pathway signature score and clinical variables were examined using logistic regression and survival analyses.Results:Our results indicated that high ALK pathway activity was a significant risk factor for hormone receptor-negative,high-grade breast cancer in the 42 datasets.ALK pathway activity was positively associated with pathological complete response(pCR)in 15 datasets annotated with patient’s neoadjuvant chemotherapy response information(overall odds ratio=1.67,P50 years old,with positive lymph nodes,or with residual disease after neoadjuvant chemotherapy.Conclusions:ALK may be involved in breast cancer tumorigenesis,and ALK pathway signature score may serve as a prognostic biomarker for breast cancer.

关键词： anaplastic lymphoma kinase Breast cancer Differentiation Disease free survival Gene signature Neoadjuvant chemotherapy response Prognosis prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Primary bone anaplastic lymphoma kinase positive anaplastic largecell lymphoma: A case report and review of the literature

引用

World Journal of Clinical Cases 2021年第14期9卷 3403-3410页

作者： Wei Zheng Qiao-Qiao Yin Tian-Chen Hui Wen-Hao Wu Qing-Qing Wu Hai-Jun Huang Mei-Juan Chen Rong Yan Yi-Cheng Huang Hong-Ying Pan Department of Infectious Diseases Zhejiang Provincial People’s Hospital People’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina The Graduate School Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina The Graduate School Qingdao UniversityQingdao 266071Shandong ProvinceChina The Second School of Clinical Medicine Zhejiang Chinese Medicinal UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Primary bone lymphoma(PBL)is an uncommon extranodal disease that represents approximately 1%-3%of lymphomas.anaplastic lymphoma kinase(ALK)positive anaplastic large-cell lymphoma(ALCL)is an extremely rare type of PBL.The aim of this report is describe the symptoms,diagnosis,and treatment of primary bone ALK-positive ALCL.CASE SUMMARY A 66-year-old man presented to our hospital with neck and shoulder pain and intermittent fever that lasted for 1 mo.After extensive evaluation,positron emission tomography-computed tomography(CT)examination showed multiple osteolytic bone lesions without other sites lesions.CT-guided biopsy of the T10 vertebral body was performed,and the pathology results showed that neoplastic cells were positive for ALK-1,CD30,and CD3.A diagnosis of primary bone ALK positive ALCL was ultimately made.The patient was in partial response after four cycle soft cyclophosphamide,doxorubicin,vincristine,and prednisone chemotherapy,and we planned to repeat the biopsy and radiological examination after completion of the fifth cycle of therapy.CONCLUSION Primary bone ALK positive ALCL is a rare disease and physicians should keep in mind that ALCL can present with isolated osseous involvement without nodal involvement,and lymphoma should be considered in the differential diagnosis of primary bone lesions.

关键词： anaplastic large cell lymphoma anaplastic lymphoma kinase Primary bone lymphoma Bone involvement Osteolysis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sarcoidosis mimicking metastases in an echinoderm microtubuleassociated protein-like 4 anaplastic lymphoma kinase positive nonsmall-lung cancer patient:A case report

引用

World Journal of Clinical Cases 2021年第13期9卷 3140-3146页

作者： Xi Chen Jie Wang Wei-Li Han Kui Zhao Zhen Chen Jian-Ying Zhou Yi-Hong Shen Department of Respiratory Diseases The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Lung Transplantation The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Positron Emission Tomography Center The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Pathology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Rearrangements of the anaplastic lymphoma kinase(ALK)gene(ALK-positive)represent an oncogenic driver in approximately 3%-5%of non-small-lung cancer(NSCLC)patients.Sarcoidosis is a multisystem disease,and its reported incidence in Asia is 1 or less per 100000 people per year.The co-occurrence of sarcoidosis and ALK-positive NSCLC is rare,and ALK-positive lung cancer is likely to spread quickly.Therefore,the co-occurrence of sarcoidosis is more easily misdiagnosed as metastatic lung cancer by radiological examination.CASE SUMMARY A 50-year-old man had a nodule in the left superior lobe,many small nodules in left superior and right lungs,and enlarged bilateral hilar,mediastinal,and right supraclavicular lymph nodes.Computed tomography-guided pulmonary biopsy of the nodule in the left superior lobe revealed echinoderm microtubuleassociated protein-like 4 gene-ALK positive NSCLC with concomitant noncaseating granuloma.This patient was treated with crizotinib.Thirty days later,a chest computed tomography scan revealed a dramatic decrease in the size of the left superior lobe nodule;however,the lesions in the right lung progressed.The right supraclavicular lymph nodes showed granulomas,and no tumor cells were identified in the specimens. The angiotensin-converting enzyme level was high.After 1 wk of methylprednisolone treatment, a significant response of all lesionswas revealed. Following radical resection of the lung cancer, noncaseatinggranulomas were observed in both lung tissues and lymph nodes, which resultedin a diagnosis of echinoderm microtubule-associated protein-like 4-ALK positiveNSCLC accompanied with sarcoidosis.CONCLUSIONOur experience illustrates that pathological evidence is needed to confirmmetastatic disease, especially when some suspected metastatic lesions arenegative for malignancy.

关键词： Lung cancer Sarcoidosis anaplastic lymphoma kinase Echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase Metastasis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Role of anaplastic lymphoma kinase Receptor in Neuroblastoma

引用

Clinical Cancer Bulletin 2022年第3期1卷 149-156页

作者： Tianfeng LI Jianmin SUN Hui ZHAO Zhenjian ZHUO Reproductive Medicine Center Affiliated Shenzhen Maternity&Child Healthcare HospitalSouthern Medical UniversityShenzhen 518000GuangdonhChina Department of Pathogen Biology and Immunology School of Basic Medical SciencesNingxia Medical UniversityYinchuan 750004NingxiaChina Division of Translational Cancer Research Department of Laboratory MedicineLund UniversityLundSweden Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Kunming Institute of Zoology Chinese Academy of Sciences-The Chinese University of Hong Kong Joint Laboratory of Bioresources and Molecular Research of Common Diseases KunmingYunnanChina State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055GuangdongChina Laboratory Animal Center School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055GuangdongChina

Neuroblastoma(NB),a frequently occurring pediatric disease,is derived from the neural crest cells in the sympathetic ganglia and adrenal medulla.Notably,it is a heterogeneous tumor consisting of many affection factors,such as the diagnosis time within the first year and the diversity of the histology and genetic features.Despite improved outcomes in NB patients,it remains a difficult clinical problem and requires new therapeutic targets and methods.The somatic acquired activation point mutations in the receptor tyrosine kinase anaplastic lymphoma kinase(ALK)represent potential targets for treating NB.Herein,we review the underlying mechanisms of ALK in NB development,the latest available strategies to block ALK constitutive activity to treat NB,and discuss the current clinical challenges of resistance to these therapies and the strategies to overcome them.

关键词： neuroblastoma anaplastic lymphoma kinase mutation ALK inhibitors therapeutic target

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regulation of Cortical Development by anaplastic lymphoma kinase

Regulation of Cortical Development by Anaplastic Lymphoma Ki...

引用

中国神经科学学会第十二届全国学术会议

作者： Rui Mao Guo Wang Rui Deng Zhengping Jia Zikai Zhou The Key Laboratory of Developmental Genes and Human Disease Ministry of Education Institute of Life Sciences Southeast University Neurosciences and Mental Health The Hospital for Sick Children Department of Physiology University of Toronto

anaplastic lymphoma kinase（Alk） is a receptor-type protein tyrosine kinase that is transiently and specifically expressed in the nervous systems during embryonic stages. Studies in Drosophila, Caenorhabditis elegans and mice have reported that Alk signaling plays important role in learning and neurogenesis while its physiological function in the development of mammalian brain remains unclear. In this study, we focused on the role of Alk in the cerebral cortical development in mice. We employed RNAi and pharmacological inhibition in cultured human neural progenitor cells（h NPCs） derived from embryonic stem cells and C57/B6 wild-type embryonic mice to inhibit Alk signaling, respectively. We examined the effects of Alk inhibition on neuronal proliferation, apoptosis and cell cycle in cultured h NPCs by FACS and immunocytochemistry. In addition, we analyzed the neuronal proliferation, differentiation and migration in embryonic mouse brain by immunohistochemistry after Alk signaling disruption. The results indicate that Alk regulates cortical development by promoting the proliferation and survival of neural progenitor cells.

关键词： anaplastic lymphoma kinase cortical development neural progenitor cells

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Hepatic inflammatory myofibroblastic tumor: A case report

引用

World Journal of Clinical Cases 2023年第18期11卷 4318-4325页

作者： Meng Tong Bo-Cheng Zhang Fei-Yu Jia Jing Wang Jing-Hua Liu Department of General Surgery Jinzhou Medical UniversityJinzhou 121001Liaoning ProvinceChina Graduate Management Office Education and Teaching DepartmentLinyi People’s HospitalLinyi 276000Shandong ProvinceChina Department of Radiology Linyi People’s HospitalLinyi 276000Shandong ProvinceChina Department of Hepatobiliary Surgery and Minimally Invasive Institute of Digestive Surgery and Prof.Cai’s Laboratory Linyi People’s HospitalLinyi 276000Shandong ProvinceChina

BACKGROUND Hepatic inflammatory myofibroblastic tumor(HIMT)is a rare type of hepatic tumor.It is always misdiagnosed and mistreated because it is primarily found with no obvious specific manifestation,and its imaging findings are diverse.CASE SUMMARY Here,we report a case of HIMT that was initially diagnosed as liver malignancy but was confirmed as HIMT by histopathology after hepatectomy.Mostly,HIMTs are infiltrated with plasma cells and stain positively for anaplastic lymphoma kinase on immunohistochemistry as well as for some other kinases.CONCLUSION HIMT can be treated with single nonsteroidal anti-inflammatory drugs and without surgery when it is diagnosed accurately.Because the etiology of HIMT is unknown and the diagnosis is difficult,the pathogenesis and clinical process need to be further studied.

关键词： Hepatic inflammatory myofibroblastic tumor Laparoscopic hepatectomy anaplastic lymphoma kinase Liver neoplasms Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ALK gene expression status in pleural effusion predicts tumor responsiveness to crizotinib in Chinese patients with lung adenocarcinoma

引用

Chinese Journal of Cancer Research 2016年第6期28卷 606-616页

作者： Zheng Wang Xiaonan Wu Xiaohong Han Gang Cheng Xinlin Mu Yuhui Zhang Di Cui Chang Liu Dongge Liu Yuankai Shi Department of Pathology Beijing HospitalNational Center of Gerontology Department of Medical Oncology Beijing HospitalNational Center of Gerontology Department of Medical Oncology National Cancer Center/Cancer Institute &Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of Respiratory and Critical Care Medicine Peking University People's Hospital Beijing Institute of Respiratory Medicine Beijing Chao-Yang Hospital Capital Medical University Department of Medical Oncology PLA Army General Hospital

Objective： The relationship between anaplastic lymphoma kinase（ALK） expression in malignant pleural effusion（MPE） samples detected only by Ventana immunohistochemistry（IHC） ALK（D5F3） and the efficacy of ALKtyrosine kinase inhibitor therapy is uncertain.Methods： Ventana anti-ALK（D5F3） rabbit monoclonal primary antibody testing was performed on 313 cell blocks of MPE samples from Chinese patients with advanced lung adenocarcinoma, and fluorescence in situ hybridization（FISH） was used to verify the ALK gene status in Ventana IHC ALK（D5F3）-positive samples. The follow-up clinical data on patients who received crizotinib treatment were recorded.Results： Of the 313 MPE samples, 27（8.6%） were confirmed as ALK expression-positive, and the Ventana IHC ALK（D5F3）-positive rate was 17.3%（27/156） in wild-type epidermal growth factor receptor（EGFR） MPE samples. Twenty-three of the 27 IHC ALK（D5F3）-positive samples were positive by FISH. Of the 11 Ventana IHC ALK（D5F3）-positive patients who received crizotinib therapy, 2 patients had complete response（CR）, 5 had partial response（PR） and 3 had stable disease（SD）.Conclusions： The ALK gene expression status detected by the Ventana IHC ALK（D5F3） platform in MPE samples may predict tumor responsiveness to crizotinib in Chinese patients with advanced lung adenocarcinoma.

关键词： anaplastic lymphoma kinase fluorescence in situ hybridization immunohistochemistry lung adenocarcinoma pleural effusion crizotinib

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：