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Regional superficial amygdala resting-state functional connectivity in adults infers childhood maltreatment severity

引用

Psychoradiology 2023年第1期3卷 162-170页

作者： Qi Liu Xinwei Song Xinqi Zhou Linghong Huang Xiaodong Zhang Lan Wang Siyu Zhu Chunmei Lan Wenxu Yang Weihua Zhao The Center of Psychosomatic Medicine Sichuan Provincial Center for Mental HealthSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 611731China Institute of Brain and Psychological Sciences Sichuan Normal UniversityChengdu 610066China Chengdu Women's and Children's Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China Institute of Electronic and Information Engineering of UESTC in Guangdong Dongguan 523808China

Background:Childhood maltreatment(CM)is a potential risk factor for some neuropsychiatric disorders in adulthood(*** and anxiety)and alters trajectories of brain *** evidence suggests that functional connectivity of the limbic system,especially the amygdala,is highly associated with childhood maltreatment,although not all studies have found *** inconsistent results may be due to differential alterations of amygdala resting-state functional connectivity(rsFC)following childhood ***:Our aim was to investigate the relationship between the rsFC of amygdala subregions and CM severity,as well as to develop a stable rsFC-based model for inferring the severity of ***:In this study,we employed the Childhood Trauma Questionnaire(CTQ)to assess CM severity in each *** explored the relationship between the rsFC of amygdala subregions(***-CMA,basolateral-BLA,superficial-SFA amygdala)and CM experience in a discovery dataset of n=110 healthy Chinese participants by linear multiple regression *** dimensional and categorical approach were performed to elucidate the relationship between rsFCs and CM severity and CM subtypes,respectively.A support vector regression model was then conducted to validate the associations between rsFCs and total CTQ ***,we also verified the model into another independent replication dataset(n=38).Results:Our findings suggested that childhood maltreatment was negatively associated with rsFC between the right superficial amyg-dala and perigenual anterior cingulate cortex(pgACC)/postcentral gyrus(PCG)but not the other two amygdala ***,SFA-pgACC coupling was more associated with physical neglect whereas the SFA-PCG was more related to emotional *** addi-tion,supervised machine learning confirmed that using these two rsFCs as predictors could stably estimate continuous maltreatment severity in both discovery and replication

关键词： Childhood maltreatment amygdala subregions Superficial amygdala Resting-state functional connectivity Neglect

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