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A designed amphiphilic peptide containing the silk fibroin motif as a potential carrier of hydrophobic drugs

Progress in Natural Science:Materials International 2009年第11期19卷 1529-1536页

作者： Qinghan Zhou~a,Juan Lin~a,Jing Wang~a,Feng Li~a,Fushan Tang~a,Xiaojun Zhao~(a,b,c,*) a Institute for Nanobiomedical Technology and Membrane Biology,West China Hospital,Sichuan University,Chengdu 610041,China b State Key Lab of Biotherapy of Human Diseases,Cancer Center,West China Medical School,West China Hospital,Sichuan University, Chengdu 610041,China c Center for Biomedical Engineering NE47-378,Massachusetts Institute of Technology,MA 02139-4307,USA Institute for Nanobiomedical Technology and Membrane Biology West China Hospital Sichuan University Chengdu 610041 China State Key Lab of Biotherapy of Human Diseases Cancer Center West China Medical School West China Hospital Sichuan University Chengdu 610041 China Center for Biomedical Engineering NE47-378 Massachusetts Institute of Technology MA 02139-4307 USA

The amphiphilic peptide is becoming attractive as a potential drug carrier to improve the dissolvability of hydrophobic drugs in an aqueous system;thus,facilitating drug uptake by target ***,we report a novel designed amphiphilic peptide,Ac-RADAGAGA-RADAGAGA -NH2,which was able to stabilize pyrene,a hydrophobic model drug we chose to study in aqueous *** designed peptide formed a colloidal suspension by encapsulating pyrene inside the peptide-pyrene *** phosphatidylcholine(EPC) vesicles were used to mimic cell bilayer *** found that pyrene was released from the peptide coating into the EPC vesicles by mixing the colloidal suspension with EPC vesicles,which was followed by steady fluorescence spectra as a function of time.A calibration curve for the amount of pyrene released into the EPC vesicles at a given time was used to determine the final concentration of pyrene released into the lipid vesicles from the peptide-pyrene *** release rate of the peptide-pyrene complex was calculated to quantify the transfer of pyrene into EPC vesicles.

关键词： Pyrene Hydrophobicity Drug carrier Fluorescence amphiphilic peptide

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两亲超短肽I3K的自组装及二氧化硅的仿生合成

两亲超短肽I3K的自组装及二氧化硅的仿生合成

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第一届全国生物物理化学会议暨生物物理化学发展战略研讨会

作者：徐海王玉鸣王生杰曹美文中国石油大学(华东)生物工程与技术中心

Self-assembly of de novo designed amphiphilic peptides produces various nanostructures[1].A curious question awaited to be solved is about the minimal size that is required for initiating amphiphilically driven *** the present study we show that the ultra-short peptide IK could readily self-assemble into stable nanotubes with diameters about 10 nm and

关键词： amphiphilic peptide Self-assembly Biomineralization

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