检索结果-南通市图书馆

Polysubstance Use and Overdose Visualized via Maps: amphetamines and Cocaine

Pharmacology & Pharmacy 2022年第5期13卷 140-148页

作者： Robert B. Raffa Joseph V. Pergolizzi Jr. Herm Cukier School of Pharmacy (Emeritus) Temple University Philadelphia PA USA University of Arizona College of Pharmacy (Adjunct) Tucson AZ USA Neumentum Summit NJ USA Enalare Therapeutics Princeton NJ USA NEMA Research Naples FL USA

Abuse of drug substances and resultant overdose deaths are no longer very straightforward—viz., attributable to a single chemical entity of known purity. The reality is that most overdose deaths involve polysubstance use (i.e., the use of combinations of substances). Further, the combinations are often of unknown purity, and even of unknown composition. Overdose deaths are at all-time highs. The depressing statistics are monitored and reported by several international and governmental organizations such as the WHO (World Health Organization), CDC (Centers for Disease Control and Prevention), several Institutes of the NIH (National Institutes of Health), Regulators, and Enforcement Agencies (e.g., DEA). The information is disseminated for free for review and use. But it is our observation that although numeric presentation is helpful and adequate for professionals, the non-expert and the visual learner often find a visual representation clearer and compelling. With this in mind, we present the “gestalt” of polysubstance use and overdose using available maps of the data. The previous article in the series considered the opioids. This one considers amphetamines and cocaine, and places the rise in opioid-associated overdose deaths in the context of other abused drugs.

关键词： Polysubstance Use/Abuse Use Disorder Overdose Maps amphetamine Cocaine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

GroupⅢmetabotropic glutamate receptors and drug addiction

引用

Frontiers of Medicine 2013年第4期7卷 445-451页

作者： Limin Mao Minglei Guo Daozhong Jin Bing Xue John Q.Wang Department of Basic Medical Science School of MedicineUniversity of Missouri-Kansas CityKansas CityMO 64108USA

Neuroadaptations of glutamatergic transmission in the limbic reward circuitry are linked to persistent drug *** data have demonstrated roles of ionotropic glutamate receptors and groupⅠandⅡmetabotropic glutamate receptors(mGluRs)in this *** evidence also identifies Gαi/o-coupled groupⅢmGluRs(mGluR4/7/8 subtypes enriched in the limbic system)as direct substrates of drugs of abuse and active regulators of drug ***-and heteroreceptors of mGluR4/7/8 reside predominantly on nerve terminals of glutamatergic corticostriatal and GABAergic striatopallidal pathways,*** presynaptic receptors regulate basal and/or phasic release of respective transmitters to maintain basal ganglia *** response to operant administration of common addictive drugs,such as psychostimulants(cocaine and amphetamine),alcohol and opiates,limbic groupⅢmGluRs undergo drastic adaptations to contribute to the enduring remodeling of excitatory synapses and to usually suppress drug seeking *** a result,a loss-of-function mutation(knockout)of individual groupⅢreceptor subtypes often promotes drug *** review summarizes the data from recent studies on three groupⅢreceptor subtypes(mGluR4/7/8)expressed in the basal ganglia and analyzes their roles in the regulation of dopamine and glutamate signaling in the striatum and their participation in the addictive properties of three major classes of drugs(psychostimulants,alcohol,and opiates).

关键词： groupⅢmetabotropic glutamate receptors cocaine amphetamine alcohol opiate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stroke recovery enhancing therapies:lessons from recent clinical trials

引用

Neural Regeneration Research 2022年第4期17卷 717-720页

作者： Andreas Rogalewski Wolf-Rüdiger Schäbitz Department of Neurology Bethel-EVKBUniversity of BielefeldBielefeldGermany

Poststroke recovery processes include restoration or compensation of function,respectively functions initially lost or new functions acquired after an *** interventions can enhance these processes and/or reduce processes impeding *** experimental studies suggest great opportunities for such treatments,but the results from recent large clinical trials using neuromodulators such as dopamine and fluoxetine are *** reasons for this are manifold affecting forward translation of results from animals models into the human ***"translational road block"is defined by differences between animals and humans with regard to the genetic and epigenetic background,size and anatomy of the brain,cerebral vascular anatomy,immune system,as well as clinical function and *** blockade includes the incompatible adaption of targets and outcomes in clinical trials with regard to prior preclinical *** example,the design of clinical recovery trials varies widely and was characterized by the selection of different clinical endpoints,the inclusion a broad spectrum of stroke subtypes and clinical syndromes as well as different time windows for treatment initiation after infarct *** review will discuss these aspects based on the results of the recent stroke recovery trials with the goal to contribute to the currently biggest unmet need in stroke research-the development of a recovery enhancing therapy that improves the functional outcome of a chronic stroke patient.

关键词： amphetamine brain chronic stroke clinical trial dopamine fluoxetine recovery regeneration serotonin reuptake inhibitor translation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

民航飞行员摇头丸戒除后放飞一例

引用

中华航空航天医学杂志 2003年第4期14卷 206-206页

作者：黄巨威叶青南方航空公司航空卫生中心广州510406

1临床资料患者男性,27岁,波音737飞机驾驶员,总飞行时间:2 800h.因2001年6月1日及14日先后两次服食摇头丸被公安机关拘留.事发当时患者在歌舞厅喝洋酒,神情兴奋,被带走后即查尿样呈阳性反应;据他事后回忆,早于6月1日他在同一歌舞厅喝洋... 详细信息

1临床资料患者男性,27岁,波音737飞机驾驶员,总飞行时间:2 800h.因2001年6月1日及14日先后两次服食摇头丸被公安机关拘留.事发当时患者在歌舞厅喝洋酒,神情兴奋,被带走后即查尿样呈阳性反应;据他事后回忆,早于6月1日他在同一歌舞厅喝洋酒后已有类似症状:脑子发热,类似酒喝多时的兴奋状态,但脑子很清醒;次日精神疲乏,以为是洋酒效应,未以为意.后经公安机关侦查证实是他人在洋酒里放了摇头丸,第一次1粒,第二次2粒.事情发生后公司行政处罚其停飞半年,航医同时收回其体检合格证,并于2001年10月改地面食堂工作,以察其行.根据航医近2年的观察,患者在食堂工作期间能按时上、下班,勤劳肯干;精神体质佳,能积极参加体育锻炼,食欲良好;期间多次不定期抽查毒品试验均(一);于2002年5月经湖南湘雅二院精神科会诊,精神状态良好,神经系统未见异常,未发现摇头丸依赖,也无躯体或心理方面戒断症状.

关键词：体格检查 Physical examination 苯丙胺 amphetamine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：