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World Journal of Clinical Cases 2022年第12期10卷 3923-3929页

作者： Fang-Chi Hsiao Yaa-Jyuhn James Meir Lung-Kun Yeh Hsin-Yuan Tan Ching-Hsi Hsiao David Hui-Kang Ma Wei-Chi Wu Hung-Chi Chen Department of Ophthalmology Chang Gung Memorial HospitalTaoyuan 333423Taiwan Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33305Taiwan Department of Medicine College of MedicineChang Gung UniversityTaoyuan 33305Taiwan Center for Tissue Engineering Chang Gung Memorial HospitalTaoyuan 333423Taiwan

BACKGROUND Streptococcus mitis(***)is an opportunistic pathogen that can lead to severe ocular *** previous reports,penetrating keratoplasty(PK)was usually adopted for the treatment of persistent corneal *** report describes an unusual case of nonhealing descemetocele caused by *** treated by antibiotics plus amniotic membrane transplantation(AMT).CASE SUMMARY A 63-year-old woman presented with a right persistent corneal ulcer that she had suffered from for the past 9 *** culture of a corneal scraping yielded *** right eye descemetocele decreased in diameter from 3 to 0.8 mm after the continuous administration of topical vancomycin and ceftriaxone for 2 *** to the slow healing,AMT was *** corneal erosion healed and gradually became *** visual acuity recovered from initially counting fingers to 100/200 at the last follow-up,67 mo after *** Antibiotics plus AMT may be an effective alternative treatment other than PK to promote epithelializationand to reduce inflammation in the corneas complicated by S. mitis keratitis.

关键词： Persistent corneal ulcer amniotic membrane transplantation Streptococcus mitis Case report

amniotic membrane transplantation for porous sphere orbital implant exposure

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第9期8卷 616-619页

作者： CHEN Yan-hong CUI Hong-guang Department of Eye Center the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310015 China

Objective: This study is aimed at describing the clinical outcome of amniotic membrane transplantation for exposure of porous sphere implants. Methods: A retrospective review of consecutive cases of porous sphere orbital implant exposure was carried out. Eight cases were presented between May 2004 and Oct. 2006 (5 males, 3 females; mean age 44.5 years). Six had enucleation and two had evisceration. Exposure occurred in two primary and six secondary. Orbital implant diameter was 22 mm in seven cases and 20 mm in one case. Six patients are with hydroxyapatite and two with high-density porous polyethylene (Medpor) orbital implants. The mean time from implantation to exposure was 1.1 months (range 0.8~2 months). All patients required surgical intervention. Results: The time of follow-up ranged from 3.0 to 28.0 months (mean 16.5 months). amniotic membrane grafting successfully closed the defect without re-exposure in all of these patients. The grafts were left bare with a mean time to conjunctiva of about 1 month (range 0.8~1.5 months). Conclusion: Exposed porous sphere implants were treated suc-cessfully with amniotic membrane graft in all of patients. The graft is easy to harvest. This technique is useful, dose not lead to prolonged socket inflammation and infection, and it is valuable application extensively.

关键词： amniotic membrane transplantation Orbital implants Exposure

Clinical outcome of combined conjunctival autograft transplantation and amniotic membrane transplantation in pterygium surgery

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 395-400页

作者： Tejsu Malla Jing Jiang Kai HU Department of Ophthalmology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School Nanjing University Nanjing 210008 Jiangsu Province China Department of Ophthalmology Zhongda Hospital Southeast University Nanjing 210009 Jiangsu Province China Nanjing Ningyi Eye Center Nanjing 210008 Jiangsu Province China

AIM： To compare long-term outcome of primary and recurrent pterygium surgery with three different techniques： combined conjunctival autograft and overlay amniotic membrane transplantation （CAT with AMT）, conjunctival autograft transplantation （CAT） alone and amniotic membrane transplantation （AMT） alone. METHODS： In this retrospective study, 142 eyes of 142 pterygium patients （104 primary, 38 recurrent）who underwent CAT （group A）, AMT （group B） or CAT with AMT （group C） respectively following surgical excision were reviewed and compared based on the recurrences and post-operative complications. RESULTS： The number of recurrence post-surgery were 17 （9 from primary, 8 from recurrent; the same description below）, 18 （10, 8） and 2 （1, 1） in groups A, B, and C respectively; dry eyes were 22 （16, 6）, 27 （18, 9） and 7 （3, 4）; conjunctival inflammations were 30 （17, 13）, 27 （16, 11） and 11 （6, 5）. Patients in group C （either pdmary or recurrent or both） mainly showed significantly better results than those in group A or B （P〈0.05） regarding above-mentioned clinical effects. CONCLUSION： Combined CAT and overly AMT have significantly lower rates of recurrence and postoperative complications for primary and recurrent pterygium surgery than CAT or AMT alone.

关键词： pterygium amniotic membrane transplantation conjunctival autograft transplantation surgery

Toxic keratopathy associated with abuse of topical anesthetics and amniotic membrane transplantation for treatment

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 938-944页

作者： Ozlem Yalcin Tok Levent Tok Inci Meltem Atay Tugba Cakmak Argun Nazire Demirci Alime Gunes Department of Ophthalmology Süleyman Demirel University Research and Education Hospital Department of Psychiatry Süleyman Demirel University Research and Education Hospital

AIMTo evaluate the clinical findings of toxic keratopathy associated with abuse of topical anesthetics and the treatment efficacy of amniotic membrane transplantation (AMT).METHODSFifteen eyes of 10 patients with abuse of topical anesthetics were included in this study. The data collected included patients' demographic information, initial best corrected visual acuity (BCVA), clinical findings, time to AMT, duration of epithelization, additional treatments, posttreatment BCVA, and the results of psychiatric *** patients were male, with the mean age of 37.9±5.4y. The patients had received 0.5% proparacaine hydrochloride due to pain resulting from foreign bodies, such as welding flash burns and car battery explosions, for a mean of 18.2±12.4d. The mean initial BCVA of the patients was 0.069±0.100. All patients had persistent epithelial defects, stromal infiltration, ring ulcer, and corneal edema. Initially, medical treatment was attempted in all cases. Because of severe pain, persistent epithelial defects and progressing stromal thinning did not improve with medical treatment, thus, the patients underwent AMT. The mean posttreatment BCVA of the patients was 0.33±0.27. All of them, except for two patients, showed improved visual acuity. One patient underwent evisceration for corneal melting and endophthalmitis in another center, and one patient underwent evisceration for severe pain of unknown origin. All 5 patients who consented to a psychiatric examination had depression, had personality disorder, and used *** appears to be an effective method for pain relief, rapid epithelial and stromal healing; however, visual prognosis is still poor despite medical and surgical interventions.

关键词： amniotic membrane transplantation ring stromal infiltration topical anesthetic abuse toxic keratopathy

Comparison of trabeculectomy and trabeculectomy with amniotic membrane transplantation in the same patient with bilateral glaucoma

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 448-451页

作者： Qing-Shan Ji Bing Qi Lian Liu Wei Lao Zhi-Hao Yang Gui-Fang Wang Guo-Cheng Yu Jing-Xiang Zhong Department of Ophthalmology the First Affiliated Hospital of Jinan University

AIM:To observe effects of trabeculectomy with amniotic membrane transplantation(AMT) in controlling postoperative intraocular pressure(IOP) in patients with medically uncontrolled glaucoma.·METHODS:This study included adult patients with requiring bilateral glaucoma *** patient underwent trabeculectomy(Non-AMT group) in one eye and with AMT(AMT group) in the other eye according to randomized *** was defined as intraocular pressure(IOP) <21mmHg without any anti-glaucoma medications at 24 months *** two groups were compared in terms of IOP,complications and success rate.·RESULTS:Thirty-four eyes of 17 patients were investigated in this *** was no statistically signifcant difference in pre-operative IOP between the two *** mean IOP was lower in AMT group compared with Non-AMT group on follow up months 12,18,and *** complications were more frequent in Non-AMT group(35.3%,6/17) compared with AMT group(5.9%,1/17).The success rate of surgery was88.2%(15/17) in Non-AMT group and 100%(17/17) in AMT group.·CONCLUSION:Trabeculectomy with AMT is an effective procedure to reduce IOP and complications,thereby improving surgical success rates.

关键词： trabeculectomy amniotic membrane transplantation glaucoma

Effects of amniotic membrane transplantation on cytokines expression in chemically burned rat corneas

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International Journal of Ophthalmology(English edition) 2011年第1期4卷 33-36页

作者： Hong-Wei Gu Dan-Mei Bian Nan Hu and Jun-Fang Zhang Department of Ophthalmology the Affiliated Hospital of Nantong University Nantong 226001 Jiangsu Province China

AIM: To investigate the effect of amniotic membrane transplantation (AMT) on the expressions of inflammatory-related, angiogenic-related and growth-related cytokines in rat corneas after chemical injury. METHODS: Alkali wounds were inflicted on the central corneas of rats by applying a round filter paper soaked in 1mol/L NaOH for 40 seconds. One week after alkali burn, 12 rats were randomly divided into 2 groups: the AMT group and the control group, and AMT was performed on the rats in the AMT group. Corneal opacity and neovascularization were observed by slit-lamp microscopy. The protein levels of interleukin (IL)-2, interferon (IFN)-gamma, IL-10 and transforming growth factor (TGF)-beta were determined by enzyme-linked immunosorbent assay 2 weeks after AMT. The mRNA levels of matrix metalloproteinase-2 (MMP-2), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) were evaluated by real-time quantitative PCR. RESULTS: In the AMT group, the corneal opacity was improved (P =0.011) and the area of corneal neovascularization was significantly decreased (P=0.005) compared with the control group. The amount of IL-2 and IFN-gamma secreted by Th1 cells were decreased after AMT, whereas the amount of IL-10 and TGF-beta secreted by Th2 cells were increased ( P <0.05). The level of MMP-2 was significantly down-regulated (P=0.013) at the nnRNA level in the AMT group, while the expression of EGF was significantly higher (P= 0.022) compared with the control. CONCLUSION: AMT may suppress corneal neovascularization after chemical injury by modulating the expressions of soluble factors.

关键词： amniotic membrane transplantation chemical injury cornea cytokine

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遗传性出血性毛细血管扩张症鼻出血介入治疗

介入放射学杂志 1999年第3期 20-20页

作者：李子祥孙成建高守乐孟庆海李娜青岛大学医学院附属医院

患者女，５１岁。因反复发作鼻出血２０年、加重７天入院。鼻出血无明显诱因，双侧鼻腔交替出血，反复发作，出血量最多达５００～６００ｍｌ。因其母和两个妹妹和一个弟弟均有鼻出血症状，因此曾诊断为遗传性出血性毛细血管扩张症，并... 详细信息

患者女，５１岁。因反复发作鼻出血２０年、加重７天入院。鼻出血无明显诱因，双侧鼻腔交替出血，反复发作，出血量最多达５００～６００ｍｌ。因其母和两个妹妹和一个弟弟均有鼻出血症状，因此曾诊断为遗传性出血性毛细血管扩张症，并给予药物及鼻腔填塞等治疗，但效果不...

关键词： Impression cytology amniotic membrane transplantation Ocular surface reconstruction