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Effect of autologous serum after amniotic membrane transplantation for persistent corneal ulcers

International Journal of Ophthalmology(English edition) 2024年第9期17卷 1639-1644页

作者： Rozaliya Hristova Petya Yankova Georgi Markov Alexander Oscar Yani Zdravkov Department of Ophthalmology Medical University SofiaUniversity Hospital AlexandrovskaSofia 1431Bulgaria Department of Clinical Immunology Medical University SofiaUniversity Hospital AlexandrovskaSofia 1431Bulgaria

AIM:To investigate the effect of adding autologous serum eye drops to the postoperative regime after amniotic membrane transplantation for severe persistent corneal ***:Forty eyes of 40 patients with persistent corneal ulcers were randomly assigned to artificial tears(sodium hyaluronate 0.2%,ATs group,n=20)or autologous serum eye drops(ASEDs,n=20)following treatment with amniotic membrane *** slit lamp images were acquired from all patients before and 30d post *** area with fibrovascular tissue was calculated using Image *** corneal sensitivity was assessed by Cochet-Bonnet aesthesiometry before and one month after *** tissue transparency was assessed with a novel optical ***:Mean age of patients was 61.65±16.47y and 57.3±19.11y in the ATs group and ASEDs group,***-two male and 18 female patients were included in the *** improvement in visual acuity was significantly greater in the ASEDs group(0.14±0.04)than the ATs(0.08±0.04;P=0.00046).Cochet-Bonnet aesthesiometry improved significantly after treatment with a similar rate between *** were no statistically significant differences in the area of postoperative fibrovascular tissue between the two groups(P=0.082).The success rate in the two groups was *** difference in densitometry between the ATs and ASEDs group was statistically significant(P=0.042)with greater reduction from baseline in the ASEDS ***:Autologous serum eye drops can lead to better visual acuity,more stable results and improved densitometry and should be considered in the postoperative care following amniotic membrane transplantation.

关键词： autologous serum amniotic membrane ocular surface persistent corneal ulcer

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amniotic membrane covering for facial nerve repair

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Neural Regeneration Research 2013年第11期8卷 975-982页

作者： Murat Karaman Arzu Tuncel Shahrouz Sheidaei Mehmet Güney ■enol Murat Hakan Karabulut Ildem Deveci Nihan Karaman Department of Otorhinolaryngology ümraniye State Hospital for Research and Training Department of Otorhinolaryngology Haydarpa a Numune State Hospital for Research and Training Department of Neurology GATA Haydarpa a State Hospital for Research and Training Department of Dentistry Turkish Military Services

amniotic membranes have been widely used in ophthalmology and skin injury repair because of their anti-inflammatory properties. In this study, we measured therapeutic efficacy and determined if amniotic membranes could be used for facial nerve repair. The facial nerves of eight rats were dissected and end-to-end anastomosis was performed. amniotic membranes were covered on the anastomosis sites in four rats. Electromyography results showed that, at the end of the 3rd and 8th weeks after amniotic membrane covering, the latency values of the facial nerves covered by amniotic membranes were significantly shortened and the amplitude values were significantly increased. Compared with simple facial nerve anastomosis, after histopathological examination, facial nerve anastomosed with amniotic membrane showed better continuity, milder inflammatory reactions, and more satisfactory nerve conduction. These findings suggest that amniotic membrane covering has great potential in facial nerve repair.

关键词： neural regeneration peripheral nerve injury tissue engineering amniotic membrane facial nerveinjury electromyography nerve anastomosis latency amplitude neuroregeneration

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amniotic membrane welded to contact lens by 1470-nm diode laser:a novel method for sutureless amniotic membrane transplantation

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 996-1000页

作者： Rifat Rasier Murat Gulsoy Department of Ophthalmology Istanbul Bilim University School of Medicine Instute of Biomedical Engineering Bogazici University

AIM: To avoid the side effects of the suture usage by welding amniotic membrane(AM) to contact lens(CL)with ***: AM was taken from pregnant women and cleaned from blood clots with sterile phosphate-buffered physiological saline solution which included *** side of the AM was spread inside of the CL and it was welded to CL by 1470 nm diode laser. And 600 μm diameter fiber tip of the laser was contacted with the epithelial side of the AM from 4 separate points. After welding excess amniotic membrane around the CL was cut with a ***: Stromal side of the AM was spread inside of the CL and then with laser fiber, different power levels and exposure times were applied on the epithelium of AM and 340 m W for seven seconds was found *** and AM attached with the spot welding effect in 4points by touching fiber tip. CL-AM welded complex did not separated from each other while holding AM that extend beyond the CL with the help of two ***: As a conclusion, it was aimed in this study to achieve the success of the conventional amniotic membrane transplantation(AMT) with the easiness of applying a CL and to avoid risks and side effects of corneal or conjunctival suturing. The results showed that the application of the CL-AM complex will be as easy as the application of a CL and lasts shortly.

关键词： amniotic membrane contact lens laser welding

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amniotic membrane for covering high myopic macular hole associated with retinal detachment following failed primary surgery

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 760-765页

作者： Gang Qiao Xiao-Juan Zhang Zi-Yan Tang Qiang-Xing Zou Chun-Mei He Xian-Ming Lei Long Zhao Yu Quan Hua-Qing Yang Kui Cao Wan-Jiang Dong Wanjiang Eye Hospital of Mianyang MianyangSichuan ProvinceChina

AIM:To evaluate the therapeutic effect of amniotic membrane(AM)for covering high myopic macular hole associated with retinal detachment following failed primary ***:Seventeen eyes of 17 patients whose axial length was more than 29 mm suffered from macular hole(MH)or MH associated with retinal detachment(RD),and had previously surgery of pars plana vitrectomy(PPV)with internal limiting membrane(ILM)peeling and silicone oil(SO)*** a year after the surgery,optical coherence tomography(OCT)showed that MH did not heal in all 17 eyes and RD was still maintained in 13 eyes of these 17 *** performed SO removal combined with AM covering on macular area and C3 F8 tamponade,and phacoemulsification combined with intraocular lens implantation simultaneously cataract *** followed up these patients for one ***:In all 17 eyes,SO was removed successfully,MHs were healed and RDs were *** eye(5.89%,1/17)had AM shifted half a month after surgery and underwent a second surgery to adjust the position of the AM and supplement C3 *** surgery,the visual acuity(VA)improved in 15 eyes(88.24%,15/17),no change in two eyes(11.76%,2/17).No serious complications occurred in all ***:AM covering is helpful to rescue the previous failure surgery of high myopic MH.

关键词： amniotic membrane high myopia macular hole retinal detachment

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amniotic membrane mesenchymal stromal cell-derived secretome in the treatment of acute ischemic stroke:A case report

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世界临床病例杂志 2023年第27期11卷 6543-6550页

作者： Fu-Hong Lin Yu-Xiao Yang Yu-Jun Wang Suresh Kumar Subbiah Xiao-Yun Wu Department of Neurology Affiliated Hospital of Chifeng CollegeChifeng 024000Inner Mongolia Autonomous RegionChina Department of Technology Beijing Protercell Biotechnology Co.Ltd.Beijing 102600China Centre for Materials Engineering and Regenerative Medicine Bharath Institute of Higher Education and ResearchChennai 600126India Department of Interventional The First Affiliated Hospital of Baotou Medical CollegeInner Mongolia University of Science and TechnologyBaotouChina

BACKGROUND Stroke is the second and third leading cause of death and disability,*** date,no definitive treatment can repair lost brain ***,various preclinical studies have been reported on mesenchymal stromal cells(MSCs)and their derivatives and their potential as alternative therapies for *** SUMMARY A 45-year-old female suffered an acute stroke,which led to paralysis in the left upper and lower *** amniotic membrane MSC-derived secretome(MSCsecretome)was intravenously transplanted once a week for 4 ***-secretomeregulated regulatory T cells were investigated for the beneficial *** clinical improvement of this patient was accompanied by an increased frequency of regulatory T cells after *** Intravenous administration of MSC-secretome can potentially treat patients who suffer from acute ischemic stroke.

关键词： Acute stroke amniotic membrane Mesenchymal stromal cells Extracellular vesicle Clinical trial Case report

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amniotic membrane covering promotes healing of cornea epithelium and improves visual acuity after debridement for fungal keratitis

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 785-789页

作者： Bo Zeng Ping Wang Ling-Juan Xu Xin-Yu Li Hong Zhang Gui-Gang Li Department of Ophthalmology Wuhan General Hospital of Guangzhou Military Department of Ophthalmology Renhe Hospital of China Three Gorges University Department of Ophthalmology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

AIM:To investigate the effect of amniotic membrane covering(AMC) on the healing of cornea epithelium and visual acuity for fungal keratitis after ***:Twenty fungal keratitis patients were divided into two groups randomly, the AMC group and the control group, ten patients each group. Both debridement of the infected cornea tissue and standard anti-fungus drugs treatments were given to every patients, monolayer amniotic membrane were sutured to the surface of the entire cornea and bulbar conjunctiva with 10-0 nylon suture for patients in the AMC *** diameter of the ulcer was determined with slit lamp microscope and the depth of the infiltration was determined with anterior segment optical coherence tomography. Uncorrected visual acuity(UCVA) was tested before surgery and three month after healing of the epithelial layer. The healing time of the cornea epithelium, visual acuity(VA) was compared between the two groups using t- ***:There was no statistical difference of the diameter of the ulcer, depth of the infiltration, height of the hypopyon and VA between the two groups beforesurgery(P >0.05). The average healing time of the AMC group was 6.89 ±2.98 d, which was statistically shorter than that of the control group(10.23±2.78d)(P <0.05).The average UCVA of the AMC group was 0.138 ±0.083,which was statistically better than that of the control group(0.053±0.068)(P <0.05).CONCLUSION:AMC surgery could promote healing of cornea epithelium after debridement for fungal keratitis and lead to better VA outcome.

关键词： amniotic membrane fungal keratitis cornea epithelium visual acuity

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amniotic membrane transplantation: an updated clinical review for the ophthalmologist

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Annals of Eye Science 2023年第2期8卷 26-38页

作者： Iyza F.Baig Nhon T.Le Zaina Al-Mohtaseb Department of Ophthalmology Baylor College of MedicineHoustonTXUSA Whitsett Vision Group HoustonTXUSA

Although amniotic membrane transplantation(AMT)has long been used as an essential surgical technique for ocular surface reconstruction,its role continues to evolve and *** the management of numerous ocular surface disorders,ranging from inflammatory to infectious,traumatic to neoplastic,the ability to perform AMT is a valuable addition to the skillset of any *** purpose of this paper is to provide ophthalmologists with an updated,evidence-based review of the clinical indications for AMT in corneal and conjunctival reconstruction,reviewing its common and even experimental applications known to *** methods of amniotic membrane preservation,the available commercial amniotic membrane products to date,and future directions for amniotic membrane use,including amniotic membrane extract eye drops(AMEED),are also *** is paramount for ophthalmologists to stay up-to-date on the applications of AMT so as to effectively incorporate this versatile treatment modality into their practice,both in the operating room and in the *** familiarizing the general ophthalmologist with its diverse applications,we hope to motivate general ophthalmologists to incorporate the use of AMT into their clinical practice,or provide guidance on how to recognize when referral to a corneal specialist for amniotic membrane application is prudent.

关键词： amniotic membrane epithelial defect cornea ocular surface reconstruction ophthalmology

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Human umbilical cord mesenchymal stem cell-loaded amniotic membrane for the repair of radial nerve injury

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Neural Regeneration Research 2013年第36期8卷 3441-3448页

作者： Zhi Li Hanjiao Qin Zishan Feng Wei Liu Ye Zhou Lifeng Yang Wei Zhao Youjun Li Affiliated Central Hospital of Shenyang Medical College Department of Endocrinology and Metabolism First Clinical Hospital of Norman Bethune College of Medicine Jilin University Shengjing Hospital China Medical University Department of Human Anatomy and Histoembryology Norman Bethune University of Medical Science

In this study, we loaded human umbilical cord mesenchymal stem cells onto human amniotic membrane with epithelial cells to prepare nerve conduits, i.e., a relatively closed nerve regeneration chamber. After neurolysis, the injured radial nerve was enwrapped with the prepared nerve conduit, which was fixed to the epineurium by sutures, with the cell on the inner surface of the conduit. Simultaneously, a 1.0 mL aliquot of human umbilical cord mesenchymal stem cell suspension was injected into the distal and proximal ends of the injured radial nerve with 1.0 cm intervals. A total of 1.75 x 107 cells were seeded on the amniotic membrane. In the control group, patients received only neurolysis. At 12 weeks after cell transplantation, more than 80% of patients exhibited obvious improvements in muscular strength, and touch and pain sensations. In contrast, these improvements were observed only in 55-65% of control patients. At 8 and 12 weeks, muscular electrophysiological function in the region dominated by the injured radial nerve was significantly better in the transplantation group than the control group. After cell transplantation, no immunological rejections were observed. These findings suggest that human umbilical cord mesenchymal stem cell-loaded amniotic membrane can be used for the repair of radial nerve injury.

关键词： neural regeneration stem cells peripheral nerve injury cells radial nerve amniotic membrane nerve electrophysiology motor sensory neuroregeneration human umbilical cord mesenchymal stem conduit nerve regeneration chamber

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Comparison of viscoelasticity between normal human sciatic nerve and amniotic membrane

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Neural Regeneration Research 2013年第14期8卷 1269-1275页

作者： Donghui Xu Conghai Zhao Huili Ma Jun Wei Dongyuan Li Department of Neurosurgery China-Japan Union HospitalJilin University Department of Road & Bridge College of TransportationJilin University

Sciatic nerve tissue was obtained from the gluteus maximus muscle segment of normal human cadavers and amniotic membrane tissue was obtained from healthy human puerperant placentas. Both tissues were analyzed for their stress relaxation and creep properties to determine suitability for transplantation applications. Human amniotic membrane and sciatic nerve tissues had similar tendencies for stress relaxation and creep properties. The stress value of the amniotic membrane stress relaxation group decreased to a greater extent compared with the sciatic nerve stress relaxation group. Similarly, the stress value of the amniotic membrane creep group increased to a greater extent compared with the sciatic nerve creep group. The stress relaxation curve for human amniotic membrane and sciatic nerve showed a logarithm correlation, while the creep curve showed an exponential correlation. These data indicate that amniotic membrane tissue has better stress relaxation and creep properties compared with sciatic nerve tissue.

关键词： neural regeneration basic research cadaver human sciatic nerve amniotic membrane stressrelaxation creep viscoelasticity stress biomechanics nerve tissue engineering neuroregeneration

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Strain and stress variations in the human amniotic membrane and fresh corpse autologous sciatic nerve anastomosis in a model of sciatic nerve injury

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Neural Regeneration Research 2012年第23期7卷 1779-1785页

作者： Chuangang Peng Qiao Zhang Qi Yang Qingsan Zhu Department of Orthopedics China-Japan Friendship HospitalJilin UniversityChangchun 130029Jilin ProvinceChina Department of Orthopedics the First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

A 10-mm long sciatic nerve injury model was established in fresh normal Chinese patient cadavers. amniotic membrane was harvested from healthy maternal placentas and was prepared into multilayered,coiled,tubular *** nerve injury models were respectively anastomosed using the autologous cadaveric sciatic nerve and human amniotic *** test results showed that maximal loading,maximal displacement,maximal stress,and maximal strain of sciatic nerve injury models anastomosed with human amniotic membrane were greater than those in the autologous nerve anastomosis *** strain-stress curves of the human amniotic membrane and sciatic nerves indicated exponential change at the first phase,which became elastic deformation curves at the second and third phases,and displayed plastic deformation curves at the fourth phase,at which point the specimens lost their bearing *** findings suggested that human amniotic membranes and autologous sciatic nerves exhibit similar stress-strain curves, good elastic properties,and certain strain and stress capabilities in anastomosis of the injured sciatic nerve.

关键词： sciatic nerve injury model autologous nerve amniotic membrane anastomosis tension mechanical properties neural regeneration

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